Results 91 to 100 of about 30,372 (240)

Kallikreins [PDF]

Biochemical Journal, 1969
E, Werle, F, Fiedler
openaire   +2 more sources

The PSA test for prostate cancer screening: an abridged Cochrane review

BJU International, EarlyView.
Objectives To assess the effects of prostate cancer screening compared to no screening in men with no prior diagnosis of prostate cancer. Methods This systematic review represents an update of a prior Cochrane review from 2013, searching multiple databases up to November 2025. We included randomised controlled trials (RCTs) of prostate cancer screening
Juan V. A. Franco, Eu Chang Hwang, Jae Hung Jung, Octavio Vaimberg, Dragan Ilic, Anne Cleves, Philipp Dahm   +6 more
wiley   +1 more source

Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases

Frontiers in Physiology, 2018
Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through vasoactive systems, such as the renin-
Carlos P. Vio, Carlos P. Vio, Daniela Salas, Carlos Cespedes, Jessica Diaz-Elizondo, Natalia Mendez, Natalia Mendez, Julio Alcayaga, Rodrigo Iturriaga   +8 more
doaj   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

KLK7 (kallikrein-related peptidase 7) [PDF]

, 2010
Review on KLK7 (kallikrein-related peptidase 7), with data on DNA, on the protein encoded, and where the gene is ...
Clements, JA, Dong, Ying, Lai, J, Clements, Judith, Y Dong, JA Clements, J Lai, Dong, Y, Lai, John   +8 more
core   +3 more sources

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Mast Cell Coupling to the Kallikrein–Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease

Frontiers in Immunology, 2017
During the course of Chagas disease, infectious forms of Trypanosoma cruzi are occasionally liberated from parasitized heart cells. Studies performed with tissue culture trypomastigotes (TCTs, Dm28c strain) demonstrated that these parasites evoke ...
Clarissa R. Nascimento, Daniele Andrade, Carla Eponina Carvalho-Pinto, Rafaela Rangel Serra, Lucas Vellasco, Guilherme Brasil, Erivan Schnaider Ramos-Junior, Erivan Schnaider Ramos-Junior, Julia Barbalho da Mota, Larissa Nogueira Almeida, Marcus V. Andrade, Marcus V. Andrade, Maria de Nazaré Correia Soeiro, Luiz Juliano, Patrícia Hessab Alvarenga, Ana Carolina Oliveira, Fernando Lencastre Sicuro, Antônio C. Campos de Carvalho, Erik Svensjö, Julio Scharfstein   +19 more
doaj   +1 more source

Kininase I drives angiotensin II‐induced hypertension through activation of the bradykinin B1 receptor

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White, Drew Theobald, Alexandra Johnston, David A. Tulis, Johanna Hannan, Srinivas Sriramula   +5 more
wiley   +1 more source

Substrate-Guided Design of a Potent and Selective Kallikrein-Related Peptidase Inhibitor for Kallikrein 4 [PDF]

, 2009
SummaryHuman kallikrein-related peptidase 4 (KLK4/prostase), a trypsin-like serine protease, is a potential target for prostate cancer treatment because of its proteolytic ability to activate many tumorigenic and metastatic pathways including the ...
Nigon, Laura, Walsh, Terry P., Stephens, Carson R., Harris, Jonathan, Reid, Janet, Walpole, Carina, Walpole, Carina M., Reid, Janet C., Buckle, Ashley M., Buckle, Ashley, De Veer, Simon, Swedberg, Joakim E., Hooper, John D., Clements, Judith A., Hooper, John, Harris, Jonathan M., Stephens, Carson, Clements, Judith, Nigon, Laura V., Takayama, Thomas K., Walsh, Terence Patrick, de Veer, Simon J., Takayama, Thomas, Swedberg, Joakim   +23 more
core   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source