Results 21 to 30 of about 164,663 (253)

Aptamer-Based Biosensors for Antibiotic Detection: A Review

Biosensors, 2018
Antibiotic resistance and, accordingly, their pollution because of uncontrolled usage has emerged as a serious problem in recent years. Hence, there is an increased demand to develop robust, easy, and sensitive methods for rapid evaluation of antibiotics
Asol Mehlhorn, Parvaneh Rahimi, Yvonne Joseph   +2 more
doaj   +1 more source

Incidence of adverse drug events among patients on second line anti-tuberculosis regimen in the littoral region of cameroon

International Journal of Mycobacteriology, 2021
Background: An adverse drug event (ADE) is an injury resulting from medical intervention associated with a drug. This study assesses the incidence of ADEs among participants on second-line drugs for tuberculosis (TB) in Cameroon.
Teyim Pride Mbuh, Henry D Meriki, Benjamin D Thumamo Pokam, Wandji Adeline, Francaise Enoka, Tchualack Ghislain, Wilfred F Mbacham, Irene Ane-Anyangwe   +7 more
doaj   +1 more source

Electrochemical Aptasensor based on the Hybridization Chain Reaction for Kanamycin Detection

International Journal of Electrochemical Science, 2021
In this work, a novel electrochemical aptamer sensor was fabricated for the sensitive and label-free detection of kanamycin in milk. The kanamycin aptamer was fixed on the magnetic nanoparticle for capturing kanamycin or complementary probe.
Qinpu Zhang, Fang Li, Xinmiao Li, Yunhong Liu, Jing Han   +4 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Synergistic Antimicrobial Effects of Baicalin Combined with Kanamycin Against MRSA: Underlying Mechanisms and Diminished Colonization on Lettuce

Pharmaceuticals
Background: The treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections is extremely challenging due to its antibiotic resistance, and the combination of plant active ingredients with antibiotics represents a potential strategy to ...
Xin Meng, Zhiyun Yu, Chao Ning, Mingtong Sun, Mengna Kang, Haiyong Guo   +5 more
doaj   +1 more source

Supplementary Material to Synthesis and biological activity of some triazole-bearing benzimidazole derivatives [PDF]

Journal of the Serbian Chemical Society, 2011
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R. K. KHITOLIYA, C. LAL, K. F. ANSAR
doaj  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

A Novel Electrochemiluminescent Biosensor Based on Nitrogen-Doped Graphyne for Ultrasensitive Kanamycin Residue Detection in Milk and Honey Samples

Chemosensors
A novel sensitive and selective electrochemiluminescence (ECL) sensor using nitrogen-doped graphyne as the platform was proposed for kanamycin (KAN) detection.
Yuxuan Liu, Tianzeng Huang, Yang Chen, Gaowa Xing, Hongmei Cao, Daixin Ye   +5 more
doaj   +1 more source

Conformational Response of 30S-bound IF3 to A-Site Binders Streptomycin and Kanamycin

Antibiotics, 2016
Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them, streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant (MDR) Mycobacterium tuberculosis.
Roberto Chulluncuy, Carlos Espiche, Jose Alberto Nakamoto, Attilio Fabbretti, Pohl Milón   +4 more
doaj   +1 more source