Results 11 to 20 of about 88,456 (270)

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

Nature Communications, 2016
Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of ...
Changsheng Du, Yanhui Duan, Wei Wei, Yingying Cai, Hui Chai, Jie Lv, Xiling Du, Jian Zhu, Xin Xie   +8 more
doaj   +2 more sources

Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake

bioRxiv, 2020
Daniel W. Bloodgood, J. Andrew Hardaway, Christina M. Stanhope, Dipanwita Pati, Melanie M. Pina, Sofia Neira, Shivani Desai, Kristen M. Boyt, Richard D. Palmiter, Thomas L. Kash   +9 more
openalex   +3 more sources

Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance. [PDF]

Brain, 2023
Ito H, Navratilova E, Vagnerova B, Watanabe M, Kopruszinski C, Moreira de Souza LH, Yue X, Ikegami D, Moutal A, Patwardhan A, Khanna R, Yamazaki M, Guerrero M, Rosen H, Roberts E, Neugebauer V, Dodick DW, Porreca F.   +17 more
europepmc   +3 more sources

Targeting the kappa opioid receptor for analgesia and antitumour effects. [PDF]

Br J Anaesth
Lambert DG, Mincer JS.
europepmc   +3 more sources

The kappa opioid receptor: from addiction to depression, and back

Frontiers in Psychiatry, 2014
Comorbidity is a major issue in psychiatry that notably associates with more severe symptoms, longer illness duration and higher service utilization.
Laurence eLalanne, Gulebru eAyranci, Brigitte L. Kieffer, Pierre-Eric eLutz   +3 more
doaj   +2 more sources

The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence [PDF]

Biological Psychiatry, 2019
Samuel D. Clark, Anissa Abi‐Dargham
openalex   +2 more sources

A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist. [PDF]

Molecules
Gisemba SA, Ferracane MJ, Murray TF, Aldrich JV.   +3 more
europepmc   +3 more sources

IUPHAR themed review: Opioid efficacy, bias, and selectivity

Pharmacological Research, 2023
Drugs acting at the opioid receptor family are clinically used to treat chronic and acute pain, though they represent the second line of treatment behind GABA analogs, antidepressants and SSRI’s.
Nokomis Ramos-Gonzalez, Barnali Paul, Susruta Majumdar   +2 more
doaj   +1 more source

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Frontiers in Pharmacology, 2023
Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit ...
Rink-Jan Lohman, Karnaker Reddy Tupally, Ajit Kandale, Peter J. Cabot, Harendra S. Parekh   +4 more
doaj   +1 more source

The opioid receptor: emergence through millennia of pharmaceutical sciences

Frontiers in Pain Research, 2023
Throughout history humanity has searched for an optimal approach to the use of opioids that maximizes analgesia while minimizing side effects. This review reflects upon the conceptualization of the opioid receptor and the critical role that the ...
Carolyn A. Fairbanks, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Cristina D. Peterson, Cristina D. Peterson   +4 more
doaj   +1 more source