Nature Communications, 2016 Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of ...
Changsheng Du +8 more
doaj +2 more sources
Kappa-opioid receptor activation reinstates nicotine self-administration in mice [PDF]
Addiction Neuroscience, 2022 Voluntary drug administration is a key facet of substance use disorder (SUD). Among the substances included under SUD, nicotine is the leading cause of preventable death. Nicotine use is also particularly sensitive to relapse, with stress being the major
Raajaram Gowrishankar +3 more
doaj +2 more sources
Does the kappa opioid receptor system contribute to pain aversion?
Frontiers in Pharmacology, 2014 The kappa opioid receptor (KOR) and the endogenous peptide-ligand dynorphin have received significant attention due the involvement in mediating a variety of behavioral and neurophysiological responses, including opposing the rewarding properties of ...
Catherine M Cahill +9 more
doaj +2 more sources
Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor. [PDF]
ACS Medicinal Chemistry Letters, 2017 The discovery and characterization of two classes of kappa opioid receptor agonists that are biased for G protein over βarrestin signaling are described.
L. Bohn, J. Aubé
semanticscholar +3 more sources
Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake
bioRxiv, 2020 Daniel W. Bloodgood +9 more
openalex +3 more sources
Determining Pharmacological Selectivity of the Kappa Opioid Receptor Antagonist LY2456302 Using Pupillometry as a Translational Biomarker in Rat and Human [PDF]
International Journal of Neuropsychopharmacology, 2015 Background: Selective kappa opioid receptor antagonism is a promising experimental strategy for the treatment of depression. The kappa opioid receptor antagonist, LY2456302, exhibits ~30-fold higher affinity for kappa opioid receptors over mu opioid ...
Linda M. Rorick‐Kehn +15 more
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Impact of renal impairment on the pharmacokinetic profile of intravenous difelikefalin, a kappa opioid receptor agonist for the treatment of pruritus. [PDF]
BMC NephrolSpencer RH +3 more
europepmc +2 more sources
Kappa opioid receptors as modulators of novelty processing [PDF]
Neuropsychopharmacology, 2023 Kathryn Braden, Daniel C. Castro
openalex +3 more sources
Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination [PDF]
Journal of Neuroscience, 2016 Feng Mei +10 more
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