Results 21 to 30 of about 71,106 (270)

Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold. [PDF]

ACS Chem Neurosci, 2022
Reed B, Miller M, Michino M, Butelman ER, Ben-Ezra A, Pikus P, Morochnik M, Kim Y, Ripka A, Vacca J, Kreek MJ.   +10 more
europepmc   +3 more sources

Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain

Pain, 2018
Kelsey Nation, Milena De Felice, Pablo Hernández, David W. Dodick, Volker Neugebauer, Edita Navratilova, Frank Porreca   +6 more
openalex   +3 more sources

Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine. [PDF]

J Med Chem
Hennessy MR, Creed SM, Gutridge AM, Rusali LE, Luo D, Sepehri B, Rhoda ES, Villegas JA, van Rijn RM, Riley AP.   +9 more
europepmc   +3 more sources

IUPHAR themed review: Opioid efficacy, bias, and selectivity

Pharmacological Research, 2023
Drugs acting at the opioid receptor family are clinically used to treat chronic and acute pain, though they represent the second line of treatment behind GABA analogs, antidepressants and SSRI’s.
Nokomis Ramos-Gonzalez, Barnali Paul, Susruta Majumdar   +2 more
doaj   +1 more source

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Frontiers in Pharmacology, 2023
Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit ...
Rink-Jan Lohman, Karnaker Reddy Tupally, Ajit Kandale, Peter J. Cabot, Harendra S. Parekh   +4 more
doaj   +1 more source

Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant. [PDF]

Mol Psychiatry
Mayer FP, Stewart A, Varman DR, Moritz AE, Foster JD, Owens AW, Areal LB, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi LD, Vaughan RA, Daws LC, Blakely RD, Ramamoorthy S.   +17 more
europepmc   +3 more sources

The opioid receptor: emergence through millennia of pharmaceutical sciences

Frontiers in Pain Research, 2023
Throughout history humanity has searched for an optimal approach to the use of opioids that maximizes analgesia while minimizing side effects. This review reflects upon the conceptualization of the opioid receptor and the critical role that the ...
Carolyn A. Fairbanks, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Cristina D. Peterson, Cristina D. Peterson   +4 more
doaj   +1 more source

Ascent of the kappa-opioid receptor in psychopharmacology [PDF]

Psychopharmacology, 2010
Often overshadowed by other members of the endogenous opioid receptor family, kappa-opioid receptors (KORs) are rapidly emerging as an important target for the study and treatment of a variety of central nervous system disorders. This Special Issue is dedicated to 18 papers that describe some of the newest and most important developments.
William A, Carlezon, Klaus A, Miczek
openaire   +2 more sources

Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors

Pharmaceuticals, 2022
The delta opioid receptor is a Gi-protein-coupled receptor (GPCR) with a broad expression pattern both in the central nervous system and the body. The receptor has been investigated as a potential target for a multitude of significant diseases including ...
Yazan J. Meqbil, Richard M. van Rijn
doaj   +1 more source

Pharmacological profiles of opioid ligands at Kappa opioid receptors [PDF]

BMC Pharmacology, 2006
Abstract Background The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse κ-opioid receptors.
Gharagozlou, Parham, Hashemi, Ezzat, DeLorey, Timothy M, Clark, J David, Lameh, Jelveh   +4 more
openaire   +2 more sources