Results 121 to 130 of about 6,766 (259)
The role of karyopherins in the regulated sumoylation of septins
Journal of Cell Biology, 2007 In the yeast Saccharomyces cerevisiae, several components of the septin ring are sumoylated during anaphase and then abruptly desumoylated at cytokinesis. We show that septin sumoylation is controlled by the interactions of two enzymes of the sumoylation
Taras Makhnevych +4 more
semanticscholar +1 more source
Investigating Ebola virus pathogenicity using molecular dynamics
BMC Genomics, 2017 Background Ebolaviruses have been known to cause deadly disease in humans for 40 years and have recently been demonstrated in West Africa to be able to cause large outbreaks.
Morena Pappalardo +5 more
doaj +1 more source
BioEssays, Volume 47, Issue 7, July 2025.Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley +1 more source
A 3D Physical Model of Karyopherin‐β2
The FASEB Journal, 2012 Karyopherin beta 2 (Kapβ2) is an importin that transports various cargo proteins into the nucleus through interactions with nucleoporins, which are proteins of the nuclear pore complex (NPC). One might overlook the significance of this protein but it actually plays a crucial role in the human body.
Mary Acheampong +12 more
openaire +1 more source
The Structure Inventory of the Nuclear Pore Complex [PDF]
, 2018 The nuclear pore complex (NPC) is the principal gateway for molecular exchange between nucleus and cytoplasm across the nuclear envelope. Due to its sheer size of estimated 50-112 MDa and its complex buildup from about 500-1000 individual proteins, it is
Schwartz, Thomas
core +1 more source
Advanced Science, Volume 12, Issue 23, June 20, 2025.Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong +15 more
wiley +1 more source
Advanced Science, Volume 12, Issue 20, May 29, 2025.Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan +8 more
wiley +1 more source
Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr
BMC Cell Biology, 2009 Background Tpr is a large protein with an extended coiled-coil domain that is localized within the nuclear basket of the nuclear pore complex. Previous studies 1 involving antibody microinjection into mammalian cells suggested a role for Tpr in nuclear ...
Frosst Phyllis D +2 more
doaj +1 more source
Towards reconciling structure and function in the nuclear pore complex [PDF]
, 2018 The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope.
Aebi, Ueli +2 more
core
Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis [PDF]
, 2016 Organelles allow specialized functions within cells to be localized, contained and independently regulated. This separation is oftentimes achieved by selectively permeable membranes, which enable control of molecular transport, signaling between ...
Inchul Cho, Joe Swift, Mark R. Jackson
core +2 more sources