Results 61 to 70 of about 2,505 (158)

Selenoprotein M is expressed during bone development [PDF]

, 2013
25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational ...
Bösl, Michael, Fuchs, Jennifer, Grosch, Melanie, Tagariello, Andreas, Winterpacht, Andreas   +4 more
core  

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.
Sumaira Anjum, Mariam Hashim, Maham Imran, Sundus Babur, Sanniah Adnan, Christophe Hano, Wisam Nabeel Ibrahim   +6 more
wiley   +1 more source

Discovery and genotyping of structural variation from long-read haploid genome sequence data [PDF]

, 2016
In an effort to more fully understand the full spectrum of human genetic variation, we generated deep single-molecule, real-time (SMRT) sequencing data from two haploid human genomes.
Boitano, Matthew, Chaisson, Mark J.P., Chin, Chen-Shin, Eichler, Evan E, Gordon, David, Graves-Lindsay, Tina A, Hoekzema, Kendra, Huddleston, John, Korlach, Jonas, Kronenberg, Zev N, Munson, Katherine M, Peluso, Paul, Steinberg, Karyn Meltz, Vives, Laura, Warren, Wes, Wilson, Richard K   +15 more
core   +2 more sources

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 6, Page 1604-1619, June 2025.
(A) The risk factors associated with OA development. (B) Exosomes derived from TNF‐α stimulate upregulation of LRP1 levels in IPFP‐MSC‐derived exosomes, thereby exerting chondroprotective effects. (C) The regulation of endocytosis by LRP1, which impacts chondrocyte proliferation and apoptosis.
Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen   +8 more
wiley   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Research Progress of Drinking Water and Trace Elements in KBD Area [PDF]

, 2023
Kaschin-beck disease (KBD) is an endemic, chronic, and deformable osteochondral disease characterized by multiple degenerations and deep cell necrosis of epiphysis, epiphysis, and articular cartilage.
Huang, Tianjiao, Kou, Jiushe
core   +2 more sources

Geographical Patterns and Determinants of Selenium Deficiency in Tibet: A Cross‐Sectional Study Based on Urinary Selenium Analysis

Earth's Future, Volume 13, Issue 2, February 2025.
Abstract Selenium is an essential micronutrient, yet its deficiency poses severe health risks, including Kashin‐Beck disease, a debilitating disorder endemic to selenium‐deficient regions like Tibet. Despite the known risks, the extent and drivers of selenium deficiency in Tibetan populations remain poorly characterized.
Yi Yang, Ru Zhang, Yangzong Deji, You Li, Yonghua Li   +4 more
wiley   +1 more source

A note on the effectiveness of selenium supplementation of Irish-grown Allium crops. [PDF]

, 2014
peer-reviewedThis study is funded by the Department of Agriculture and Food through the Network and Team Building Initiative of the Food Institutional Research Measure (FIRM Reference Number 06/NITARFC6).Onions and other Allium crops contain high levels ...
Brunton, Nigel, Finn, Leo, Gaffney, Michael, Rai, Dilip K., Reilly, Kim, Valverde, Juan   +5 more
core  

Selenium deficiency impairs host innate immune response and induces susceptibility to infection [PDF]

, 2009
Background Susceptibility or resistance to infection with Listeria monocytogenes correlates with Selenium (Se) deficiency in response to infection. Results Se-deficient mouse models of listeriosis were used to study the innate immune response during the ...
Wei Lei, Hu Yi, Luo Jing, Wang Haijing, Wang Chengmin, Duan Mingxing, He Hongxuan   +6 more
core   +1 more source

Evaluation of Soil Samples Preparation Techniques for Detecting Selenium by Using Atomic Fluorescence Spectroscopy‐Based Detection

Journal of Analytical Methods in Chemistry, Volume 2025, Issue 1, 2025.
Selenium (Se) can cause poisoning in the human body, including dry, brittle, and easy‐to‐fall‐off hair, white spots and longitudinal lines of nails, skin damage, nervous system abnormalities, and even death. In order to optimize the experimental process for the sensitive detection of Se in samples by atomic fluorescence spectrometry (AFS), an excellent
Lin Zhu, Zheng-he Hu, Xiu-long Chen, Surat Hongsibsong, Tulika Banerjee   +4 more
wiley   +1 more source