Results 1 to 10 of about 30,883 (246)

Metabolism of HT-2 Toxin and T-2 Toxin in Oats [PDF]

Toxins, 2016
The Fusarium mycotoxins HT-2 toxin (HT2) and T-2 toxin (T2) are frequent contaminants in oats. These toxins, but also their plant metabolites, may contribute to toxicological effects. This work describes the use of 13C-assisted liquid chromatography–high-
Jacqueline Meng-Reiterer, Christoph Bueschl, Justyna Rechthaler, Franz Berthiller, Marc Lemmens, Rainer Schuhmacher   +5 more
doaj   +4 more sources

A Simple and Specific Noncompetitive ELISA Method for HT-2 Toxin Detection [PDF]

Toxins, 2017
We developed an HT-2 toxin-specific simple ELISA format with a positive read-out. The assay is based on an anti-immune complex (IC) scFv antibody fragment, which is genetically fused with alkaline phosphatase (AP).
Henri O. Arola, Antti Tullila, Alexis V. Nathanail, Tarja K. Nevanen   +3 more
doaj   +7 more sources

Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants [PDF]

EFSA Journal, 2022
In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Jean‐Charles Leblanc, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Sven Daenicke, Carlo Stefano Nebbia, Isabelle P Oswald, Elena Rovesti, Hans Steinkellner, Laurentius (Ron) Hoogenboom   +21 more
doaj   +5 more sources

Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T₃ Inhibit Toxicity of HT-2? [PDF]

Toxins, 2019
Thyroid hormone triiodothyronine (T3) plays an important role in coordinated endochondral ossification and hypertrophic differentiation of the growth plate, while aberrant thyroid hormone function appears to be related to skeletal malformations ...
Feng’e Zhang, Mikko Juhani Lammi, Wanzhen Shao, Pan Zhang, Yanan Zhang, Haiyan Wei, Xiong Guo   +6 more
doaj   +5 more sources

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study [PDF]

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +2 more sources

A Two-Year Occurrence of Fusarium T-2 and HT-2 Toxin in Croatian Cereals Relative of the Regional Weather [PDF]

Toxins, 2021
To investigate into the T-2 and HT-2 toxin occurrence, 240 samples of unprocessed cereals (maize, wheat, barley, and oats) were sampled from different fields located in three Croatian regions during 2017–2018. In all samples, sum concentrations of T-2/HT-
Maja Kiš, Ana Vulić, Nina Kudumija, Bojan Šarkanj, Vesna Jaki Tkalec, Krunoslav Aladić, Mario Škrivanko, Sanja Furmeg, Jelka Pleadin   +8 more
doaj   +2 more sources

Potential Role of Individual and Combined Effects of T-2 Toxin, HT-2 Toxin and Neosolaniol on the Apoptosis of Porcine Leydig Cells [PDF]

Toxins, 2022
T-2 toxin usually co-occurs with HT-2 toxin and neosolaniol (NEO) in the grains and feed. Our previous studies found that T-2 toxin and its metabolites’ binary or ternary combination exposure to porcine Leydig cells (LCs) displayed synergism in certain ...
Jingru Xu, Zhihui Zhao, Wenbo Guo, Aru Ling, Jianhua Wang, Xichun Wang, Junhua Yang   +6 more
doaj   +2 more sources

Metabolism of the Fusarium Mycotoxins T-2 Toxin and HT-2 Toxin in Wheat [PDF]

Journal of Agricultural and Food Chemistry, 2015
To investigate the metabolic fate of HT-2 toxin (HT2) and T-2 toxin (T2) in wheat (Triticum aestivum L.), an untargeted metabolomics study utilizing stable isotopic labeling and liquid chromatography-high resolution mass spectrometry was performed. In total, 11 HT2 and 12 T2 derived in planta biotransformation products were annotated putatively.
Nathanail, Alexis V., Varga, Elisabeth, Meng-Reiterer, Jacqueline, Bueschl, Christoph, Michlmayr, Herbert, Malachova, Alexandra, Fruhmann, Philipp, Jestoi, Marika, Peltonen, Kimmo, Adam, Gerhard, Lemmens, Marc, Schuhmacher, Rainer, Berthiller, Franz   +12 more
openaire   +3 more sources

Human and animal dietary exposure to T‐2 and HT‐2 toxin [PDF]

EFSA Journal, 2017
T-2 toxin (T2) and HT-2 (HT2) toxin are trichothecenes, which form part of the group of Fusarium mycotoxins. Food and feed samples used to estimate human dietary and animal exposure were reported either as the individual results for T2 and/or, HT2, and/or as the sum of the two.
Arcella, Davide, Gergelova, Petra, Innocenti, Matteo Lorenzo, Steinkellner, Hans   +3 more
openaire   +3 more sources

T-2 and HT-2 Toxins: Toxicity, Occurrence and Analysis: A Review

Toxins, 2023
One of the major classes of mycotoxins posing serious hazards to humans and animals and potentially causing severe economic impact to the cereal industry are the trichothecenes, produced by many fungal genera.
Julie Meneely, Brett Greer, Oluwatobi Kolawole, Christopher Elliott   +3 more
doaj   +4 more sources