Results 1 to 10 of about 31,566 (246)

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study [PDF]

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +2 more sources

A Two-Year Occurrence of Fusarium T-2 and HT-2 Toxin in Croatian Cereals Relative of the Regional Weather [PDF]

Toxins, 2021
To investigate into the T-2 and HT-2 toxin occurrence, 240 samples of unprocessed cereals (maize, wheat, barley, and oats) were sampled from different fields located in three Croatian regions during 2017–2018. In all samples, sum concentrations of T-2/HT-
Maja Kiš, Ana Vulić, Nina Kudumija, Bojan Šarkanj, Vesna Jaki Tkalec, Krunoslav Aladić, Mario Škrivanko, Sanja Furmeg, Jelka Pleadin   +8 more
doaj   +2 more sources

T-2 and HT-2 Toxins: Toxicity, Occurrence and Analysis: A Review

Toxins, 2023
One of the major classes of mycotoxins posing serious hazards to humans and animals and potentially causing severe economic impact to the cereal industry are the trichothecenes, produced by many fungal genera.
Julie Meneely, Brett Greer, Oluwatobi Kolawole, Christopher Elliott   +3 more
doaj   +4 more sources

Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. [PDF]

PLoS ONE, 2013
The trichothecene mycotoxin T-2 toxin is a common contaminant of food and feed and is also present in processed cereal derived products. Cytotoxic effects of T-2 toxin and its main metabolite HT-2 toxin are already well described with apoptosis being a ...
Maria Weidner, Sabine Hüwel, Franziska Ebert, Tanja Schwerdtle, Hans-Joachim Galla, Hans-Ulrich Humpf   +5 more
doaj   +2 more sources

Determination of T-2 and HT-2 Toxins in Seed of Milk Thistle [Silybum marianum (L.) Gaertn.] Using Immunoaffinity Column by UPLC-MS/MS

Toxins, 2022
Milk thistle [Silybum marianum (L.) Gaertn.] achieved a significant increase in interest over the past few years from local and foreign pharmaceutical corporations.
Rastislav Boško, Marek Pernica, Sylvie Běláková, Marie Bjelková, Helena Pluháčková   +4 more
doaj   +1 more source

Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity

Frontiers in Nutrition, 2022
BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia, Sirong Shi, Bolun Cheng, Shiqiang Cheng, Li Liu, Peilin Meng, Xuena Yang, Xiaoge Chu, Yan Wen, Feng Zhang, Xiong Guo   +10 more
doaj   +1 more source

Potential Toxicity and Mechanisms of T-2 and HT-2 Individually or in Combination on the Intestinal Barrier Function of Porcine Small Intestinal Epithelial Cells

Toxins, 2023
Under natural conditions, T-2 toxin can be easily metabolized to HT-2 toxin by deacetylation, and T-2 and HT-2 are usually co-contaminated in grain and feed at a high detected rate.
Weihua He, Jianhua Wang, Mengyi Han, Lihua Wang, Ling Li, Jiahui Zhang, Siqi Chen, Jiayi Guo, Xiaohu Zhai, Junhua Yang   +9 more
doaj   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Broad-specific monoclonal antibody based IACs purification coupled UPLC-MS/MS method for T-2 and HT-2 toxin determination in maize and cherry samples

Food and Agricultural Immunology, 2020
In this work, broad-specific monoclonal antibody based immunoaffinity columns (IACs) coupled to ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) for purification and determination of T-2 and HT-2 toxin in maize and ...
Yanshen Li, Shaoxia Lin, Yunhui Wang, Xin Mao, Yongning Wu, Yunguo Liu, Daquan Chen   +6 more
doaj   +1 more source

Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins

Toxins, 2019
In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu, Xia-Lu Lin, Xi Wang, Zhi-Guang Ping, Xiong Guo   +4 more
doaj   +1 more source