Results 11 to 20 of about 31,566 (246)

Metabolism of HT-2 Toxin and T-2 Toxin in Oats [PDF]

Toxins, 2016
The Fusarium mycotoxins HT-2 toxin (HT2) and T-2 toxin (T2) are frequent contaminants in oats. These toxins, but also their plant metabolites, may contribute to toxicological effects. This work describes the use of 13C-assisted liquid chromatography–high-
Jacqueline Meng-Reiterer, Christoph Bueschl, Justyna Rechthaler, Franz Berthiller, Marc Lemmens, Rainer Schuhmacher   +5 more
doaj   +5 more sources

A Simple and Specific Noncompetitive ELISA Method for HT-2 Toxin Detection [PDF]

Toxins, 2017
We developed an HT-2 toxin-specific simple ELISA format with a positive read-out. The assay is based on an anti-immune complex (IC) scFv antibody fragment, which is genetically fused with alkaline phosphatase (AP).
Henri O. Arola, Antti Tullila, Alexis V. Nathanail, Tarja K. Nevanen   +3 more
doaj   +8 more sources

Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T₃ Inhibit Toxicity of HT-2? [PDF]

Toxins, 2019
Thyroid hormone triiodothyronine (T3) plays an important role in coordinated endochondral ossification and hypertrophic differentiation of the growth plate, while aberrant thyroid hormone function appears to be related to skeletal malformations ...
Feng’e Zhang, Mikko Juhani Lammi, Wanzhen Shao, Pan Zhang, Yanan Zhang, Haiyan Wei, Xiong Guo   +6 more
doaj   +6 more sources

Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants [PDF]

EFSA Journal, 2022
In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Jean‐Charles Leblanc, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Sven Daenicke, Carlo Stefano Nebbia, Isabelle P Oswald, Elena Rovesti, Hans Steinkellner, Laurentius (Ron) Hoogenboom   +21 more
doaj   +5 more sources

Metabolism of the Fusarium Mycotoxins T-2 Toxin and HT-2 Toxin in Wheat. [PDF]

J Agric Food Chem, 2015
To investigate the metabolic fate of HT-2 toxin (HT2) and T-2 toxin (T2) in wheat (Triticum aestivum L.), an untargeted metabolomics study utilizing stable isotopic labeling and liquid chromatography-high resolution mass spectrometry was performed. In total, 11 HT2 and 12 T2 derived in planta biotransformation products were annotated putatively.
Nathanail AV, Varga E, Meng-Reiterer J, Bueschl C, Michlmayr H, Malachova A, Fruhmann P, Jestoi M, Peltonen K, Adam G, Lemmens M, Schuhmacher R, Berthiller F.   +12 more
europepmc   +3 more sources

Distribution of T-2 toxin and HT-2 toxin during experimental feeding of yellow mealworm (Tenebrio molitor). [PDF]

Mycotoxin Res, 2021
AbstractWithin the European Union (EU), edible insects need to be approved as “Novel Food” according to Regulation (EU) 2015/2283 and must comply with the requirements of European food law with regard to microbiological and chemical food safety. Substrates used for feeding insects are susceptible to the growth of Fusarium spp.
Piacenza N, Kaltner F, Maul R, Gareis M, Schwaiger K, Gottschalk C.   +5 more
europepmc   +5 more sources

Human and animal dietary exposure to T-2 and HT-2 toxin. [PDF]

EFSA J, 2017
T-2 toxin (T2) and HT-2 (HT2) toxin are trichothecenes, which form part of the group of Fusarium mycotoxins. Food and feed samples used to estimate human dietary and animal exposure were reported either as the individual results for T2 and/or, HT2, and/or as the sum of the two.
European Food Safety Authority (EFSA), Arcella D, Gergelova P, Innocenti ML, Steinkellner H.   +4 more
europepmc   +3 more sources

Potential Role of Individual and Combined Effects of T-2 Toxin, HT-2 Toxin and Neosolaniol on the Apoptosis of Porcine Leydig Cells [PDF]

Toxins, 2022
T-2 toxin usually co-occurs with HT-2 toxin and neosolaniol (NEO) in the grains and feed. Our previous studies found that T-2 toxin and its metabolites’ binary or ternary combination exposure to porcine Leydig cells (LCs) displayed synergism in certain ...
Jingru Xu, Zhihui Zhao, Wenbo Guo, Aru Ling, Jianhua Wang, Xichun Wang, Junhua Yang   +6 more
doaj   +2 more sources

Comparison of Anorectic Potencies of Type A Trichothecenes T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol. [PDF]

Toxins (Basel), 2018
Trichothecene mycotoxins are common contaminants in cereal grains and negatively impact human and animal health. Although anorexia is a common hallmark of type B trichothecenes-induced toxicity, less is known about the anorectic potencies of type A trichothecenes.
Zhang J, Zhang H, Liu S, Wu W, Zhang H.
europepmc   +4 more sources

Debunking the Myth of Fusarium poae T-2/HT-2 Toxin Production. [PDF]

J Agric Food Chem
Fusarium poae is commonly detected in field surveys of Fusarium head blight (FHB) of cereal crops and can produce a range of trichothecene mycotoxins. Although experimentally validated reports of F. poae strains producing T-2/HT-2 trichothecenes are rare, F.
Witte TE, Hicks C, Hermans A, Shields S, Overy DP.   +4 more
europepmc   +3 more sources