Results 21 to 30 of about 63,605 (287)

Integrated Cytotoxicity and Metabolomics Analysis Reveals Cell-Type-Specific Responses to Co-Exposure of T-2 and HT-2 Toxins [PDF]

Toxins
T-2 toxin and HT-2 toxin are commonly found in agricultural products and animal feed, posing serious effects to both humans and animals. This study employed combination index (CI) modeling and metabolomics to assess the combined cytotoxic effects of T-2 ...
Weihua He, Zuoyin Zhu, Jingru Xu, Chengbao Huang, Jianhua Wang, Qinggong Wang, Xiaohu Zhai, Junhua Yang   +7 more
doaj   +2 more sources

Determination of T-2 and HT-2 Toxins in Seed of Milk Thistle [Silybum marianum (L.) Gaertn.] Using Immunoaffinity Column by UPLC-MS/MS

Toxins, 2022
Milk thistle [Silybum marianum (L.) Gaertn.] achieved a significant increase in interest over the past few years from local and foreign pharmaceutical corporations.
Rastislav Boško, Marek Pernica, Sylvie Běláková, Marie Bjelková, Helena Pluháčková   +4 more
doaj   +1 more source

Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity

Frontiers in Nutrition, 2022
BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia, Sirong Shi, Bolun Cheng, Shiqiang Cheng, Li Liu, Peilin Meng, Xuena Yang, Xiaoge Chu, Yan Wen, Feng Zhang, Xiong Guo   +10 more
doaj   +1 more source

Assay and Relationship of HT-2 Toxin and T-2 Toxin Formation in Liquid Culture [PDF]

Applied Microbiology, 1975
Both T-2 toxin and HT-2 toxin can be conveniently quantitated in crude extracts by using a combination of thin-layer chromatography and fluorodensitometry. This technique was used to follow the production of these toxins by liquid cultures of Fusarium poae (NRRL 3287).
F N, Kotsonis, R A, Ellison
openaire   +2 more sources

Potential Toxicity and Mechanisms of T-2 and HT-2 Individually or in Combination on the Intestinal Barrier Function of Porcine Small Intestinal Epithelial Cells

Toxins, 2023
Under natural conditions, T-2 toxin can be easily metabolized to HT-2 toxin by deacetylation, and T-2 and HT-2 are usually co-contaminated in grain and feed at a high detected rate.
Weihua He, Jianhua Wang, Mengyi Han, Lihua Wang, Ling Li, Jiahui Zhang, Siqi Chen, Jiayi Guo, Xiaohu Zhai, Junhua Yang   +9 more
doaj   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Report of the 2009 Proficiency Test of the Community Reference Laboratory for Mycotoxins, for the Network of National Reference Laboratories, Regarding the Determination of T-2 and HT-2 Toxins in Cereal Products [PDF]

, 2010
A proficiency test was conducted by the Community Reference Laboratory for Mycotoxins with 29 European National Reference Laboratories (NRLs) for Mycotoxins and one laboratory from a candidate country.
AMBROSIO Massimo, BOUTEN Katrien, BREIDBACH Andreas, KROEGER-NEGOITA Katy, LERDA Donata, STROKA Joerg   +5 more
core   +1 more source

Mycotoxin exposure assessments in a multi-center European validation study by 24-hour dietary recall and biological fluid sampling [PDF]

, 2020
The European Food Consumption Validation (EFCOVAL) project includes 600 men and women from Belgium, the Czech Republic, France, the Netherlands, and Norway, who had given serum and 24-hour urine samples, and completed 24-hour dietary recall (24-HDR ...
Abbeddou, Souheila, Arcella, Davide, Claeys, Liesel, De Boevre, Marthe, De Keyzer, Willem, De Ruyck, Karl, De Saeger, Sarah, De Vries, Jeanne, Huybrechts, Inge, Ocke, Marga, Ruprich, Jiri, Yang, Shupeng   +11 more
core   +1 more source

Broad-specific monoclonal antibody based IACs purification coupled UPLC-MS/MS method for T-2 and HT-2 toxin determination in maize and cherry samples

Food and Agricultural Immunology, 2020
In this work, broad-specific monoclonal antibody based immunoaffinity columns (IACs) coupled to ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) for purification and determination of T-2 and HT-2 toxin in maize and ...
Yanshen Li, Shaoxia Lin, Yunhui Wang, Xin Mao, Yongning Wu, Yunguo Liu, Daquan Chen   +6 more
doaj   +1 more source

Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins

Toxins, 2019
In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu, Xia-Lu Lin, Xi Wang, Zhi-Guang Ping, Xiong Guo   +4 more
doaj   +1 more source