Results 41 to 50 of about 10,432,347 (134)

Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China. [PDF]

Cell Death Dis, 2021
Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to improve our understanding of the gut microbiota structure in KBD patients of different grades and ...
Wang X, Ning Y, Li C, Gong Y, Huang R, Hu M, Poulet B, Xu K, Zhao G, Zhou R, Lammi MJ, Guo X.   +11 more
europepmc   +2 more sources

Kashin-Beck Disease: A Risk Factor for Sarcopenia and Its Interaction with Selenium. [PDF]

Nutrients
Objectives: We aimed to explore the possible effects of Kashin–Beck disease (KBD) on the risk of sarcopenia and its possible interaction in the association between the risk of sarcopenia and element concentration.
Wu H, Chen Z, Wang O, Jiang T, Huang J, Wang J, Lin J.   +6 more
europepmc   +2 more sources

A Metabolomics Study of Feces Revealed That a Disturbance of Selenium-Centered Metabolic Bioprocess Was Involved in Kashin-Beck Disease, an Osteoarthropathy Endemic to China. [PDF]

Nutrients, 2023
Background: Kashin–Beck disease (KBD) is a distinct osteoarthropathy in China with an unclear pathogenesis. This study aims to explore whether perturbations in the intestine metabolome could be linked to KBD individuals.
Wen Y, Wang B, Shi P, Chu X, Shi S, Yao Y, Zhang L, Zhang F.   +7 more
europepmc   +2 more sources

Comparison of the major cell populations among osteoarthritis, Kashin–Beck disease and healthy chondrocytes by single-cell RNA-seq analysis

Cell Death and Disease, 2021
Chondrocytes are the key target cells of the cartilage degeneration that occurs in Kashin–Beck disease (KBD) and osteoarthritis (OA). However, the heterogeneity of articular cartilage cell types present in KBD and OA patients and healthy controls is ...
Xi Wang, Y. Ning, Pan Zhang, B. Poulet, Ruitian Huang, Y. Gong, Minhan Hu, Cheng Li, Rong-jiao Zhou, M. Lammi, Xiong Guo   +10 more
semanticscholar   +1 more source

Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. [PDF]

PLoS ONE, 2018
Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, the prevalence of OA in Kashin-Beck disease (KBD) and non-KBD endemic areas was examined, respectively.
Wei Lian, Hui Liu, QuanQuan Song, Yun Qi Liu, Li Yan Sun, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +12 more
doaj   +1 more source

Health-related quality of life in patients with Kashin-Beck disease is lower than in those with osteoarthritis: a cross-sectional study. [PDF]

J Orthop Surg Res, 2023
Background Kashin–Beck disease (KBD) is an endemic deformable bone and joint disease, which affects the quality of life (QOL) of patients. We conducted a cross-sectional study of the QOL of KBD patients by a new KBD quality of life (KBDQOL) questionnaire.
Jin Z, Wu X, Sun Z, Chen M, Yang B, Dong X, Liu S, Chang Y, Xu C, Yi Z, Ling M.   +10 more
europepmc   +2 more sources

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. [PDF]

PLoS Genetics, 2009
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia.
Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik   +6 more
doaj   +1 more source

The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

Journal of Orthopaedic Surgery and Research, 2019
Background Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA).
Quan Quan Song, Li Yan Sun, Chun Hui Li, Yu Jiao Liu, Si Lu Cui, Yun Qi Liu, Yan Hong Cao, Jun Rui Pei, Yue Wang, Wei Lian, Zhe Jiao, Qing Deng, Jun Yu   +12 more
doaj   +1 more source

Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease

Journal of Orthopaedic Surgery and Research, 2018
Background Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers.
Wei Lian, Hui Liu, Li Yan Sun, Yun Qi Liu, Si Lu Cui, Yue Wang, Quan Quan Song, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +14 more
doaj   +1 more source

Whole-Transcriptome Sequencing of Knee Joint Cartilage from Kashin-Beck Disease and Osteoarthritis Patients. [PDF]

Int J Mol Sci
The aim of this study was to provide a comprehensive understanding of similarities and differences in mRNAs, lncRNAs, and circRNAs within cartilage for Kashin–Beck disease (KBD) compared to osteoarthritis (OA). We conducted a comparison of the expression
Han L, Cheng B, Wei W, Liu L, Cheng S, Liu H, Jia Y, Wen Y, Zhang F.   +8 more
europepmc   +2 more sources