Results 41 to 50 of about 1,046 (117)

Contrasting Effects of HT‐2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
HT‐2 toxin triggers chondrocyte damage and matrix metabolism disorders in KBD via suppressing ZIP6. ZIP6 knockdown alleviates these dysfunctions through FoxO, cAMP and TNF pathways, clarifying the molecular mechanism of cartilage injury. ABSTRACT Kashin‐Beck disease (KBD) is a chronic, endemic osteoarticular disorder associated with T‐2 toxin exposure,
Yang Liu, Yu Zhang, Ruitian Huang, Lulu Bai, Lian Liu, Chaowei Wang, Yirong Qin, Hui Wang, Xiong Guo, Xi Wang, Yujie Ning   +10 more
wiley   +1 more source

Polygenic Prediction of Equestrian Sport Discipline Among Horses Bred for Jumping and Dressage

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Horses bred for different equestrian sports vary in physical, physiological and behavioural requirements. Characterising genetic markers associated with discipline provides an opportunity to improve identification of horses best suited to either jumping or dressage.
Emmeline W. Hill, Haige Han, Amy R. Holtby, Heinrich Anhold, Beatrice A. McGivney   +4 more
wiley   +1 more source

COL9A1 gene polymorphism is associated with Kashin-Beck disease in a northwest Chinese Han population. [PDF]

PLoS ONE, 2015
OBJECTIVE: We sought to determine whether genomic polymorphism in collagen IX genes (COL9A) was associated with Kashin-Beck disease (KBD). METHODS: Twenty seven single nucleotide polymorphisms (SNPs) in COL9AI, COL9A2 and COL9A3 were genotyped in 274 KBD
Xiaowei Shi, Feng Zhang, Aili Lv, Yan Wen, Xiong Guo   +4 more
doaj   +1 more source

Investigation of selenium nutritional status and dietary pattern among children in Kashin-Beck disease endemic areas in Shaanxi Province, China using duplicate portion sampling method

Environment International, 2022
Background and objectives: Selenium deficiency is a primary risk factor of Kashin-Beck disease (KBD). This study aimed to investigate whether children in endemic areas could maintain sufficient selenium intake after termination of selenium supplement ...
Yujie Ning, Minhan Hu, Sijie Chen, Feiyu Zhang, Xiaodong Yang, Qingping Zhang, Yi Gong, Ruitian Huang, Yanli Liu, Feihong Chen, Leilei Pei, Xiong Guo, Lianke Kang, Xinyi Wang, Yan Zhang, Xi Wang   +15 more
doaj   +1 more source

Evaluation of Storage Conditions and Pre‐Treatment Methods to Mitigate Aflatoxin Contamination in Commonly Used Chinese Herbal Medicines

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
High temperature and humidity significantly promote aflatoxin contamination in herbal medicines. This research demonstrates that drying, vacuum packaging, and sulfur fumigation are effective strategies to minimize contamination and extend shelf life, whereas UV exposure proves ineffective for decontamination.
Tung Leong Fong, Tingyuan Xing, Yau‐Tuen Chan, Zixin Feng, Guoyi Tang, Yibin Feng, Cheng Zhang, Ning Wang   +7 more
wiley   +1 more source

Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population

BMC Medical Genetics, 2017
Background Many osteoarthritis (OA) susceptibility genes have been identified in recent years. Given the overlap in the phenotype of joint inflammation between OA and Kashin-Beck disease (KBD), the aim of this study is to explore whether the reported OA ...
Zhengfu Tai, Lulin Huang, Fang Lu, Yi Shi, Shi Ma, Jing Cheng, He Lin, Xin Liu, Yuanfeng Li, Zhenglin Yang   +9 more
doaj   +1 more source

The molecular mechanism study of COMP involved in the articular cartilage damage of Kashin-Beck disease

Bone & Joint Research, 2020
Aims: Kashin-Beck disease (KBD) is a kind of chronic osteochondropathy, thought to be caused by environmental risk factors such as T-2 toxin. However, the exact aetiology of KBD remains unclear.
Mei Ma, Xiao Liang, Xi Wang, Lu Zhang, Shiqiang Cheng, Xiong Guo, Feng Zhang, Yan Wen   +7 more
doaj   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Unlocking the Nutritional Potential of Gamma Amino Butyric Acid (GABA) Rice: Towards a Sustainable Approach to Metabolic Disorder Remedies

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This study addresses the critical issue of nutrient deficiencies associated with the widespread consumption of conventional milled rice, which often lacks essential vitamins and minerals due to the removal of the bran layer during processing. It demonstrated that controlled germination of paddy rice, followed by parboiling, substantially increases the ...
Uloma E. Onyeka, Ekpeno Sunday Ukpong, Chinedu B. Azudialu, Sali A. Ndindeng, Kalimuthu Senthilkumar, Christian O. Dimkpa   +5 more
wiley   +1 more source

Extracellular vesicles derived from engineered BMSCs improve damaged cartilage in mice with osteoarthritis by delivering PBX1

Stem Cell Research & Therapy
Background The beneficial effects of bone marrow mesenchymal stem cells (BMSCs) have been linked to their secreted extracellular vesicles (EVs). These EVs can suppress cartilage degradation and prevent apoptosis in articular cells.
Yunqi Zhang, Fusen Wang, Huan Yu, Changqing Jiang, Zhong Li, Rongqiang Bu, Jun Yu   +6 more
doaj   +1 more source