Results 41 to 50 of about 2,505 (158)

Selenium supplementation modulates apoptotic processes in thyroid follicular cells [PDF]

, 2017
Selenium (Se) is an essential micronutrient modulating several physiopathological processes in the human body. The aim of the study is to characterize the molecular effects determined by Se-supplementation in thyroid follicular cells, using as model the ...
Ahsan, Antonelli, Arscott, Blot, Cho, Clark, Contempre, Dixon, Drutel, Effraimidis, Esposito, Faure, Fernandes, Hammond, Huang, Huang, Kaufmann, Kaushal, Kim, Kipp, Kohrle, Kohrle, Kucharzewski, Lee, Maria, Mirzayans, Mitsiades, Passaro, Pham, Prasad, Rayman, Rayman, Saito, Salmaso, Shan, Song, Stassi, Villette, Wallenberg, Wang, Wang, Wang, Watt, Wichman, Winther, Winther, Xu, Yao, Yu   +48 more
core   +1 more source

Osteoarthritis Deformans Endemica: Etiology, Diagnosis, Treatment, Prevention

Bolʹ, Sustavy, Pozvonočnik, 2012
The paper deals with generalization of historical, epidemiological, etiologic, diagnostic, preventive and therapeutic data of osteoarthritis deformans endemica (Kashin — Beck disease). Taking into account the growing trend of deterioration of the current
T.V. Frolova, О.V. Okhapkina, Yu.V. Sorokolat, Ye.G. Koleushko   +3 more
doaj   +1 more source

Animal models of Kashin-Beck disease exposed to environmental risk factors: Methods and comparisons

Ecotoxicology and Environmental Safety, 2022
The main etiological mechanism for Kashin-Beck disease (KBD) is deep chondrocyte necrosis induced by environmental risk factors (ERFs). The scholars have conducted several epidemiological, cellular, and animal model studies on ERFs.
Fang-fang Yu, Juan Zuo, Lei Sun, Shui-yuan Yu, Xiao-li Lei, Jun-hua Zhu, Guo-yu Zhou, Xiong Guo, Yue Ba   +8 more
doaj   +1 more source

Genetic aberrations in macroautophagy genes leading to diseases [PDF]

, 2018
The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis.
Klionsky, Daniel J, Reggiori, Fulvio, van Beek, Nienke   +2 more
core   +1 more source

Selenium status is positively associated with bone mineral density in healthy aging European men [PDF]

, 2016
Objective It is still a matter of debate if subtle changes in selenium (Se) status affect thyroid function tests (TFTs) and bone mineral density (BMD). This is particularly relevant for the elderly, whose nutritional status is more vulnerable. Design and
A Hoeg, AC Bianco, AC Looker, Annewieke W. van den Beld, Antonia Hoeg, AW van den Beld, AW van den Beld, B Contempre, B Hollenbach, Birgit Hollenbach, C Di Cosmo, C Riese, Carolien M. Beukhof, DC Arikan, E Odabasi, E Schoenmakers, FJ Kok, GF Combs Jr, H Liu, J Hoeflich, J Zhang, JJ Cao, JM Guralnik, JS Goodwin, Karen M. Tordjman, L Schomburg, L Schomburg, L Schomburg, LB Rasmussen, LH Duntas, LJ Ubink-Veltmaat, Lutz Schomburg, Marco Medici, MP Brugts, MP Rayman, MP Rayman, MS Geybels, N Pietschmann, NE Allen, O Olivieri, R Moreno-Reyes, Robin P. Peeters, RP Peeters, SZ Liu, Theo J. Visser, U Schweizer, W. Edward Visser, Wouter W. de Herder   +47 more
core   +7 more sources

Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis

Arthritis Research & Therapy, 2018
Background Kashin-Beck disease (KBD) is an endemic osteochondropathy of unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar clinical manifestations and pathological changes to articular cartilage with KBD ...
Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang, Xiong Guo   +10 more
doaj   +1 more source

Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]

, 2015
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi, Arne Holmgren, Chan PH, Chen EP, Chu FF, Daiber A, Elias S. J. Arnér, Geismann C, Hogan B, Jaarsma D, Jian-Hong Zhu, Jin R, Leitzmann C, Li JJ, Li JJ, Lu YP, Makino N, Miranda-Vizuete A, Mirochnitchenko O, Motoori S, Mulder DW, Ogata M, Oury TD, Papaioannou V, Radi R, Sandbach JM, Takahara S, Thimmulappa RK, Tome ME, Vogel U, Wang F, Wen JK, Wen-Hsing Cheng, Wispe JR, Woychik RP, Xin Gen Lei, Ye-Shih Ho, Yongping Bao, Yoshida T   +38 more
core   +1 more source

Spatial distribution and determinants of health loss from Kashin-Beck disease in Bin County, Shaanxi Province, China

BMC Public Health, 2021
Background Kashin-Beck disease (KBD) is one of the major endemic diseases in China, which severely impacts the physical health and life quality of people.
Jing Wang, Xiaoya Wang, Hairong Li, Linsheng Yang, Yingchun Li, Chang Kong   +5 more
doaj   +1 more source

Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T₃ Inhibit Toxicity of HT-2?

Toxins, 2019
Thyroid hormone triiodothyronine (T3) plays an important role in coordinated endochondral ossification and hypertrophic differentiation of the growth plate, while aberrant thyroid hormone function appears to be related to skeletal malformations ...
Feng’e Zhang, Mikko Juhani Lammi, Wanzhen Shao, Pan Zhang, Yanan Zhang, Haiyan Wei, Xiong Guo   +6 more
doaj   +1 more source

Medical Geology : a globally emerging discipline [PDF]

, 2007
Medical Geology, the study of the impacts of geologic materials and processes on animal and human health, is a dynamic emerging discipline bringing together the geoscience, biomedical, and public health communities to solve a wide range of environmental ...
Bunnell, Joseph E., Centeno, Jose A., Finkelman, Robert B., Selinus, O. (Olle)   +3 more
core   +3 more sources