Results 21 to 30 of about 1,046 (117)

Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin-Beck Disease. [PDF]

Depress Anxiety
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable research has been conducted in KBD patients. Methods: We conducted a field investigation in KBD areas in Northwest
Liu Y, Wen Y, Yang Z, Zhou R, Hui J, Li C, Xu G, Liu C, Liu H, Cheng B, Jia Y, Guo X, Zhang F.   +12 more
europepmc   +2 more sources

Transcriptome-wide RNA m6A methylation profiles in an endemic osteoarthropathy, Kashin-Beck disease. [PDF]

J Cell Mol Med
Abstract Kashin‐Beck disease (KBD) is a chronic degenerative, disabling disease of the bones and joints and its exact aetiology and pathogenesis remain uncertain. This study is to investigate the role of m6A modification in the pathogenesis of KBD. Combined analysis of m6A MeRIP‐Seq and RNA‐Seq were used to analyse human peripheral blood samples from ...
Zhang Q, Yang X, Deng X, Niu H, Zhao Y, Wen J, Wang S, Liu H, Guo X, Wu C.   +9 more
europepmc   +2 more sources

COMPREHENSIVE GEOCHEMICAL RESEARCH OF THE ENVIRONMENTAL COMPONENTS IN ENDEMIC AREAS OF TRANSBAIKALIA

Известия Томского политехнического университета: Инжиниринг георесурсов, 2021
The relevance of the research. Kashin–Beck disease, or Urov disease, is a classic example of endemic diseases. However, unlike other diseases, the cause of this one has not yet been determined.
Leonid P. Rikhvanov, Bulat R. Soktoev, Natalia V. Baranovskaya, Elena V. Ageeva, Alexandra I. Belyanovskaya, Mariya A. Deriglazova, Dmitry V. Yusupov, Ekaterina S. Epova, Mariya A. Solodukhina, Leonid V. Zamana, Larisa A. Mikhailova, Tatiana S. Bolshunova, Anastasiya S. Mironova, Dina V. Narkovich, Alexander F. Sudyko, Darya A. Polyakova   +15 more
doaj   +1 more source

Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. [PDF]

PLoS ONE, 2018
Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, the prevalence of OA in Kashin-Beck disease (KBD) and non-KBD endemic areas was examined, respectively.
Wei Lian, Hui Liu, QuanQuan Song, Yun Qi Liu, Li Yan Sun, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +12 more
doaj   +1 more source

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. [PDF]

PLoS Genetics, 2009
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia.
Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik   +6 more
doaj   +1 more source

The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

Journal of Orthopaedic Surgery and Research, 2019
Background Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA).
Quan Quan Song, Li Yan Sun, Chun Hui Li, Yu Jiao Liu, Si Lu Cui, Yun Qi Liu, Yan Hong Cao, Jun Rui Pei, Yue Wang, Wei Lian, Zhe Jiao, Qing Deng, Jun Yu   +12 more
doaj   +1 more source

Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease

Journal of Orthopaedic Surgery and Research, 2018
Background Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers.
Wei Lian, Hui Liu, Li Yan Sun, Yun Qi Liu, Si Lu Cui, Yue Wang, Quan Quan Song, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +14 more
doaj   +1 more source

Expression profile analysis of mycotoxin-related genes in cartilage with endemic osteochondropathy kashin-beck disease

BMC Musculoskeletal Disorders, 2012
Background Kashin-Beck Disease (KBD) is an endemic osteochondropathy. Mycotoxins are believed to play an important role in the pathogenesis of KBD. Because the molecular mechanism of mycotoxin-induced cartilage lesions remains unclear, there is not ...
Zhang Feng, Guo Xiong, Wang Weizhuo, Wu Shixun, Ma Weijuan, Yan Hua   +5 more
doaj   +1 more source

Animal models of Kashin-Beck disease exposed to environmental risk factors: Methods and comparisons

Ecotoxicology and Environmental Safety, 2022
The main etiological mechanism for Kashin-Beck disease (KBD) is deep chondrocyte necrosis induced by environmental risk factors (ERFs). The scholars have conducted several epidemiological, cellular, and animal model studies on ERFs.
Fang-fang Yu, Juan Zuo, Lei Sun, Shui-yuan Yu, Xiao-li Lei, Jun-hua Zhu, Guo-yu Zhou, Xiong Guo, Yue Ba   +8 more
doaj   +1 more source

Osteoarthritis Deformans Endemica: Etiology, Diagnosis, Treatment, Prevention

Bolʹ, Sustavy, Pozvonočnik, 2012
The paper deals with generalization of historical, epidemiological, etiologic, diagnostic, preventive and therapeutic data of osteoarthritis deformans endemica (Kashin — Beck disease). Taking into account the growing trend of deterioration of the current
T.V. Frolova, О.V. Okhapkina, Yu.V. Sorokolat, Ye.G. Koleushko   +3 more
doaj   +1 more source