Results 21 to 30 of about 2,505 (158)

The molecular mechanism study of COMP involved in the articular cartilage damage of Kashin-Beck disease [PDF]

Bone & Joint Research, 2020
Aims: Kashin-Beck disease (KBD) is a kind of chronic osteochondropathy, thought to be caused by environmental risk factors such as T-2 toxin. However, the exact aetiology of KBD remains unclear.
Mei Ma, Xiao Liang, Xi Wang, Lu Zhang, Shiqiang Cheng, Xiong Guo, Feng Zhang, Yan Wen   +7 more
doaj   +2 more sources

Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population [PDF]

Open Medicine
Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (
He Na, Hong Aiwen, Zhao Kun, Zhang Zhefan, Wang Shengli, Jia Yaofei   +5 more
doaj   +2 more sources

A comparative metabolomic analysis reveals the metabolic variations among cartilage of Kashin-Beck disease and osteoarthritis [PDF]

Bone & Joint Research
Aims: The metabolic variations between the cartilage of osteoarthritis (OA) and Kashin-Beck disease (KBD) remain largely unknown. Our study aimed to address this by conducting a comparative analysis of the metabolic profiles present in the cartilage of ...
Hong Chang, Li Liu, Qingping Zhang, Gangyao Xu, Jianpeng Wang, Ping Chen, Cheng Li, Xianni Guo, Zhengjun Yang, Feng Zhang   +9 more
doaj   +2 more sources

Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin-Beck Disease. [PDF]

Depress Anxiety
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable research has been conducted in KBD patients. Methods: We conducted a field investigation in KBD areas in Northwest
Liu Y, Wen Y, Yang Z, Zhou R, Hui J, Li C, Xu G, Liu C, Liu H, Cheng B, Jia Y, Guo X, Zhang F.   +12 more
europepmc   +2 more sources

Transcriptome-wide RNA m6A methylation profiles in an endemic osteoarthropathy, Kashin-Beck disease. [PDF]

J Cell Mol Med
Abstract Kashin‐Beck disease (KBD) is a chronic degenerative, disabling disease of the bones and joints and its exact aetiology and pathogenesis remain uncertain. This study is to investigate the role of m6A modification in the pathogenesis of KBD. Combined analysis of m6A MeRIP‐Seq and RNA‐Seq were used to analyse human peripheral blood samples from ...
Zhang Q, Yang X, Deng X, Niu H, Zhao Y, Wen J, Wang S, Liu H, Guo X, Wu C.   +9 more
europepmc   +2 more sources

Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. [PDF]

PLoS ONE, 2018
Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, the prevalence of OA in Kashin-Beck disease (KBD) and non-KBD endemic areas was examined, respectively.
Wei Lian, Hui Liu, QuanQuan Song, Yun Qi Liu, Li Yan Sun, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +12 more
doaj   +1 more source

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. [PDF]

PLoS Genetics, 2009
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia.
Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik   +6 more
doaj   +1 more source

The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

Journal of Orthopaedic Surgery and Research, 2019
Background Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA).
Quan Quan Song, Li Yan Sun, Chun Hui Li, Yu Jiao Liu, Si Lu Cui, Yun Qi Liu, Yan Hong Cao, Jun Rui Pei, Yue Wang, Wei Lian, Zhe Jiao, Qing Deng, Jun Yu   +12 more
doaj   +1 more source

Selenium in biology: Facts and medical perspectives [PDF]

, 2000
Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Brigelius-Flohé, Regina, Böck, August, Flohé, Leopold, Gärtner, Roland, Köhrle, Josef, Meyer, Ortwin   +5 more
core   +1 more source

Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease

Journal of Orthopaedic Surgery and Research, 2018
Background Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers.
Wei Lian, Hui Liu, Li Yan Sun, Yun Qi Liu, Si Lu Cui, Yue Wang, Quan Quan Song, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +14 more
doaj   +1 more source