Effects of selenium-mediated RUNX2 overexpression and its transcriptome alterations on Chondrocyte injury in Kashin Beck disease [PDF]
Frontiers in Cell and Developmental BiologyObjectiveKashin-Beck disease (KBD) is a nutrition-related osteoarthropathy characterized by excessive apoptosis and matrix destruction. Micronutrient selenium (Se) deficiency is recognized as a major environmental risk factor.
Di Zhang +5 more
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A comparative metabolomic analysis reveals the metabolic variations among cartilage of Kashin-Beck disease and osteoarthritis [PDF]
Bone & Joint ResearchAims: The metabolic variations between the cartilage of osteoarthritis (OA) and Kashin-Beck disease (KBD) remain largely unknown. Our study aimed to address this by conducting a comparative analysis of the metabolic profiles present in the cartilage of ...
Hong Chang +9 more
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Differential expression of cyclins CCNB1 and CCNG1 is involved in the chondrocyte damage of kashin-beck disease [PDF]
Frontiers in Genetics, 2022 The purpose of this study was clarify the relationship between the differential expression of cyclins CCNB1 and CCNG1 and chondrocyte damage in Kashin-Beck disease. Systematic review and high-throughput sequencing of chondrocytes derived from Kashin-Beck
Kaidiriye Setiwalidi +20 more
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Combined Proximal Tibial Osteotomy for Adult Kashin–Beck Disease with Severe Varus Knee Osteoarthritis: Case Report and Literature Review [PDF]
Orthopaedic Surgery, 2022 Background Kashin–Beck disease (KBD) is an endemic, chronic osteoarthropathy that seriously affects joint function and can lead to severe knee deformity.
Yunfei Liu +4 more
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ATAC-seq reveals the roles of chromatin accessibility in the chondrocytes of Kashin–Beck disease compared with primary osteoarthritis [PDF]
Frontiers in Genetics, 2023 Objective: This study aimed to investigate the roles of accessible chromatin in understanding the different pathogeneses between Kashin–Beck disease (KBD) and primary osteoarthritis (OA).Methods: Articular cartilages of KBD and OA patients were collected,
Sen Wang +5 more
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Identifying discriminative features for diagnosis of Kashin-Beck disease among adolescents [PDF]
BMC Musculoskeletal Disorders, 2021 Introduction Diagnosing Kashin-Beck disease (KBD) involves damages to multiple joints and carries variable clinical symptoms, posing great challenge to the diagnosis of KBD for clinical practitioners.
Yanan Zhang +11 more
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Identification of N-Glycoproteins of Knee Cartilage from Adult Osteoarthritis and Kashin-Beck Disease Based on Quantitative Glycoproteomics, Compared with Normal Control Cartilage [PDF]
Cells, 2022 Glycoproteins are involved in the development of many diseases, while the type and content of N-glycoproteins in the cartilage of osteoarthritis (OA) and Kashin–Beck disease (KBD) are still unclear.
Jing Han +10 more
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Patients with Kashin-Beck Disease Obtained Lower Functional Activities but Better Satisfaction Than Patients with Osteoarthritis After Total Knee Arthroplasty: A Retrospective Study [PDF]
Clinical Interventions in Aging, 2022 Liangzhi Zhang,1 Hui Li,1,2 Lulu Bai,1,2 NaiChun Ji1 1Department of Sports Health Research Center, Xi ‘an Medical University, Xi’an City, People’s Republic of China; 2Department of Knee Surgery, Hong Hui Hospital, Xi’an Jiaotong University, Xi’an City ...
Zhang L, Li H, Bai L, Ji N
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Animal models of Kashin-Beck disease exposed to environmental risk factors: Methods and comparisons
Ecotoxicology and Environmental Safety, 2022 The main etiological mechanism for Kashin-Beck disease (KBD) is deep chondrocyte necrosis induced by environmental risk factors (ERFs). The scholars have conducted several epidemiological, cellular, and animal model studies on ERFs.
Fang-fang Yu +8 more
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The Status of Selenium and Zinc in the Urine of Children From Endemic Areas of Kashin-Beck Disease Over Three Consecutive Years [PDF]
Frontiers in Nutrition, 2022 Selenium deficiency is one of the main risk factors for Kashin-Beck disease (KBD). This study aimed to detect the status of selenium and zinc in the urine of children from endemic areas of KBD over three consecutive years and to evaluate whether selenium
Xin Kang +15 more
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