Results 31 to 40 of about 1,011 (111)

Expression profile analysis of mycotoxin-related genes in cartilage with endemic osteochondropathy kashin-beck disease

BMC Musculoskeletal Disorders, 2012
Background Kashin-Beck Disease (KBD) is an endemic osteochondropathy. Mycotoxins are believed to play an important role in the pathogenesis of KBD. Because the molecular mechanism of mycotoxin-induced cartilage lesions remains unclear, there is not ...
Zhang Feng, Guo Xiong, Wang Weizhuo, Wu Shixun, Ma Weijuan, Yan Hua   +5 more
doaj   +1 more source

Osteoarthritis Deformans Endemica: Etiology, Diagnosis, Treatment, Prevention

Bolʹ, Sustavy, Pozvonočnik, 2012
The paper deals with generalization of historical, epidemiological, etiologic, diagnostic, preventive and therapeutic data of osteoarthritis deformans endemica (Kashin — Beck disease). Taking into account the growing trend of deterioration of the current
T.V. Frolova, О.V. Okhapkina, Yu.V. Sorokolat, Ye.G. Koleushko   +3 more
doaj   +1 more source

Animal models of Kashin-Beck disease exposed to environmental risk factors: Methods and comparisons

Ecotoxicology and Environmental Safety, 2022
The main etiological mechanism for Kashin-Beck disease (KBD) is deep chondrocyte necrosis induced by environmental risk factors (ERFs). The scholars have conducted several epidemiological, cellular, and animal model studies on ERFs.
Fang-fang Yu, Juan Zuo, Lei Sun, Shui-yuan Yu, Xiao-li Lei, Jun-hua Zhu, Guo-yu Zhou, Xiong Guo, Yue Ba   +8 more
doaj   +1 more source

Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis

Arthritis Research & Therapy, 2018
Background Kashin-Beck disease (KBD) is an endemic osteochondropathy of unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar clinical manifestations and pathological changes to articular cartilage with KBD ...
Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang, Xiong Guo   +10 more
doaj   +1 more source

Spatial distribution and determinants of health loss from Kashin-Beck disease in Bin County, Shaanxi Province, China

BMC Public Health, 2021
Background Kashin-Beck disease (KBD) is one of the major endemic diseases in China, which severely impacts the physical health and life quality of people.
Jing Wang, Xiaoya Wang, Hairong Li, Linsheng Yang, Yingchun Li, Chang Kong   +5 more
doaj   +1 more source

Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T₃ Inhibit Toxicity of HT-2?

Toxins, 2019
Thyroid hormone triiodothyronine (T3) plays an important role in coordinated endochondral ossification and hypertrophic differentiation of the growth plate, while aberrant thyroid hormone function appears to be related to skeletal malformations ...
Feng’e Zhang, Mikko Juhani Lammi, Wanzhen Shao, Pan Zhang, Yanan Zhang, Haiyan Wei, Xiong Guo   +6 more
doaj   +1 more source

Whole-exome sequencing for the identification of susceptibility genes of Kashin-Beck disease.

PLoS ONE, 2014
ObjectiveTo identify and investigate the susceptibility genes of Kashin-Beck disease (KBD) in Chinese population.MethodsWhole-exome capturing and sequencing technology was used for the detection of genetic variations in 19 individuals from six families ...
Zhenxing Yang, Yu Xu, Hongrong Luo, Xiaohong Ma, Qiang Wang, Yingcheng Wang, Wei Deng, Tao Jiang, Guangqing Sun, Tingting He, Jingchu Hu, Yingrui Li, Jun Wang, Tao Li, Xun Hu   +14 more
doaj   +1 more source

Polygenic Prediction of Equestrian Sport Discipline Among Horses Bred for Jumping and Dressage

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Horses bred for different equestrian sports vary in physical, physiological and behavioural requirements. Characterising genetic markers associated with discipline provides an opportunity to improve identification of horses best suited to either jumping or dressage.
Emmeline W. Hill, Haige Han, Amy R. Holtby, Heinrich Anhold, Beatrice A. McGivney   +4 more
wiley   +1 more source

Chemical composition of natural waters from the Urov endemic area

Desalination and Water Treatment
Owing to the importance of drinking water in human nutrition, in this study, we performed a comparative analysis of the chemical composition of drinking water from settlements endemic to Kashin–Beck disease and from territories that are not endemic to ...
Vadim Ermakov, Vladimir Safonov, Valentina Danilova, Uliana Gulyaeva, Sergey Tyutikov   +4 more
doaj   +1 more source

Investigation of selenium nutritional status and dietary pattern among children in Kashin-Beck disease endemic areas in Shaanxi Province, China using duplicate portion sampling method

Environment International, 2022
Background and objectives: Selenium deficiency is a primary risk factor of Kashin-Beck disease (KBD). This study aimed to investigate whether children in endemic areas could maintain sufficient selenium intake after termination of selenium supplement ...
Yujie Ning, Minhan Hu, Sijie Chen, Feiyu Zhang, Xiaodong Yang, Qingping Zhang, Yi Gong, Ruitian Huang, Yanli Liu, Feihong Chen, Leilei Pei, Xiong Guo, Lianke Kang, Xinyi Wang, Yan Zhang, Xi Wang   +15 more
doaj   +1 more source