Results 31 to 40 of about 1,046 (117)

Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis

Arthritis Research & Therapy, 2018
Background Kashin-Beck disease (KBD) is an endemic osteochondropathy of unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar clinical manifestations and pathological changes to articular cartilage with KBD ...
Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang, Xiong Guo   +10 more
doaj   +1 more source

Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin–Beck disease

BMC Musculoskeletal Disorders, 2020
Background Several questionnaires have been used to assess the health status of patients with Kashin-Beck disease (KBD) in clinical trials, but the evidence regarding the responsiveness of these instruments in KBD patients is limited.
Lei Yang, Dimiao Wang, Xiuxia Li, Hangjing Yuan, Hua Fang, Xiong Guo   +5 more
doaj   +1 more source

SIRT1/PGC-1α-regulated mitochondrial biogenesis is involved in T-2 toxin-induced chondrocyte injury

Ecotoxicology and Environmental Safety
T-2 toxin, a type A trichothecene mycotoxin, has been implicated as an environmental risk factor for Kashin-Beck disease (KBD), an endemic osteoarthropathy characterized by cartilage damage.
Chenxi Wang, Junfeng Zhou, Weichang Zhang, Yue Zhao, Jiaxin Li, Jiayuan Li, Jun Yu, Silu Cui   +7 more
doaj   +1 more source

Spatial distribution and determinants of health loss from Kashin-Beck disease in Bin County, Shaanxi Province, China

BMC Public Health, 2021
Background Kashin-Beck disease (KBD) is one of the major endemic diseases in China, which severely impacts the physical health and life quality of people.
Jing Wang, Xiaoya Wang, Hairong Li, Linsheng Yang, Yingchun Li, Chang Kong   +5 more
doaj   +1 more source

Antioxidant Responses to Dietary Supplementation With Non‐Enriched and Selenium‐Enriched Mushrooms and Selenized Yeast in Piglets

Molecular Nutrition &Food Research, Volume 70, Issue 19, 15 October 2026.
The findings highlight tissue‐specific responses to dietary selenium supplementation, with hepatic antioxidant modulation occurring without changes in plasma parameters, while selenium deposition patterns differed among tissues, emphasizing the complex relationship between selenium sources, metabolism, and antioxidant defense.
Diene France de de Souza, Gabriel Cipriano Rocha, Dairon Pérez Fuentes, Lucas Eduardo Oliveira Porto, Pedro Vitoriano Oliveira, Marliane de Cássia Soares da Silva, Maria Catarina Megumi Kasuya, Maiane de Paula Alves, Monique Renon Eller   +8 more
wiley   +1 more source

Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T₃ Inhibit Toxicity of HT-2?

Toxins, 2019
Thyroid hormone triiodothyronine (T3) plays an important role in coordinated endochondral ossification and hypertrophic differentiation of the growth plate, while aberrant thyroid hormone function appears to be related to skeletal malformations ...
Feng’e Zhang, Mikko Juhani Lammi, Wanzhen Shao, Pan Zhang, Yanan Zhang, Haiyan Wei, Xiong Guo   +6 more
doaj   +1 more source

Cartilage Extracellular Matrix Homeostasis in Knee Osteoarthritis: Pathomechanisms and Therapeutic Targeting

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Knee osteoarthritis (KOA) is a degenerative joint disease primarily driven by the disruption of homeostasis in the chondrocyte extracellular matrix (CECM). This review systematically examines the central role of CECM homeostasis in KOA pathogenesis and summarizes recent advances in this field.
Chao Du, Jiwei Zhong, Jialin Yang, Yanbo Huang, Qi Liu, Dongdong Cao, Tianci Guo, Jida Wang, Aifeng Liu   +8 more
wiley   +1 more source

Genomic Insights Into the Body Size Evolution in Felidae (Mammalia: Carnivora)

Ecology and Evolution, Volume 16, Issue 9, September 2026.
This study performed reannotation of the genomes of two felid species and conducted the first genomic analysis of body size variation and evolution in Felidae. Our results demonstrate that felid body size evolution is driven by adaptive changes in both core signaling pathways and individual key genes.
Shihu Zhao, Tian Xia, Xuesong Mei, Chen Qiu, Ying Zhang, Chao Zhao, Xiaoyang Wu, Xiaodong Gao, Jiaohui Fang, Jianqun Ding, Zhenglong Wang, Xiufeng Yang, Honghai Zhang   +12 more
wiley   +1 more source

Chemical composition of natural waters from the Urov endemic area

Desalination and Water Treatment
Owing to the importance of drinking water in human nutrition, in this study, we performed a comparative analysis of the chemical composition of drinking water from settlements endemic to Kashin–Beck disease and from territories that are not endemic to ...
Vadim Ermakov, Vladimir Safonov, Valentina Danilova, Uliana Gulyaeva, Sergey Tyutikov   +4 more
doaj   +1 more source

Whole-exome sequencing for the identification of susceptibility genes of Kashin-Beck disease.

PLoS ONE, 2014
ObjectiveTo identify and investigate the susceptibility genes of Kashin-Beck disease (KBD) in Chinese population.MethodsWhole-exome capturing and sequencing technology was used for the detection of genetic variations in 19 individuals from six families ...
Zhenxing Yang, Yu Xu, Hongrong Luo, Xiaohong Ma, Qiang Wang, Yingcheng Wang, Wei Deng, Tao Jiang, Guangqing Sun, Tingting He, Jingchu Hu, Yingrui Li, Jun Wang, Tao Li, Xun Hu   +14 more
doaj   +1 more source