Results 51 to 60 of about 1,011 (111)

Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis

International Journal of Endocrinology, 2014
Here, we sought to establish an experimental autoimmune thyroiditis rat model induced by bovine thyroglobulin (bTg) injection and to investigate pathological changes and variations in serum interferon-γ-inducible protein of 10 kDa (IP-10) in thyroid ...
Si-lu Cui, Jun Yu, Liu Shoujun
doaj   +1 more source

Geographical Patterns and Determinants of Selenium Deficiency in Tibet: A Cross‐Sectional Study Based on Urinary Selenium Analysis

Earth's Future, Volume 13, Issue 2, February 2025.
Abstract Selenium is an essential micronutrient, yet its deficiency poses severe health risks, including Kashin‐Beck disease, a debilitating disorder endemic to selenium‐deficient regions like Tibet. Despite the known risks, the extent and drivers of selenium deficiency in Tibetan populations remain poorly characterized.
Yi Yang, Ru Zhang, Yangzong Deji, You Li, Yonghua Li   +4 more
wiley   +1 more source

Arthroscopic Ankle Arthrodesis for Treating Osteoarthritis in a Patient with Kashin-Beck Disease

Case Reports in Medicine, 2014
Kashin-Beck disease (KBD) is an endemic degenerative osteoarthritis. Death of cartilage and growth plate is the pathologic feature; therefore, KBD involves skeletal deformity and often results in osteoarthritis.
Kenjiro Iwasa, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka   +6 more
doaj   +1 more source

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +1 more source

Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis

Scientific Reports, 2017
Kashin-Beck disease (KBD) is a chronic osteochondropathy with unclear pathogeny. In this study, we compared the microRNA expression profiles of 16 KBD patients, 16 osteoarthritis (OA) patients and 16 rheumatoid arthritis (RA) patients and 16 healthy ...
Wenhong Wu, Awen He, Yan Wen, Xiao Xiao, Jingcan Hao, Feng Zhang, Xiong Guo   +6 more
doaj   +1 more source

Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.

PLoS ONE, 2013
BackgroundKashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD.ObjectiveTo investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699),
Lulin Huang, Yi Shi, Fang Lu, Hong Zheng, Xiaoqi Liu, Bo Gong, Jiyun Yang, Ying Lin, Jing Cheng, Shi Ma, He Lin, Zhenglin Yang   +11 more
doaj   +1 more source

Evaluation of Soil Samples Preparation Techniques for Detecting Selenium by Using Atomic Fluorescence Spectroscopy‐Based Detection

Journal of Analytical Methods in Chemistry, Volume 2025, Issue 1, 2025.
Selenium (Se) can cause poisoning in the human body, including dry, brittle, and easy‐to‐fall‐off hair, white spots and longitudinal lines of nails, skin damage, nervous system abnormalities, and even death. In order to optimize the experimental process for the sensitive detection of Se in samples by atomic fluorescence spectrometry (AFS), an excellent
Lin Zhu, Zheng-he Hu, Xiu-long Chen, Surat Hongsibsong, Tulika Banerjee   +4 more
wiley   +1 more source

A Se Nanoparticle/MgFe‐LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction

Advanced Science, Volume 11, Issue 33, September 4, 2024.
Selenium nanoparticle‐decorated MgFe‐LDH nanosheets are loaded on a bioactive glass scaffold to develop a postoperative “one‐stop‐shop” therapeutic platform for osteosarcoma. Abstract Despite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain critical concerns.
Yixin Bian, Kexin Zhao, Tingting Hu, Chaoliang Tan, Ruizheng Liang, Xisheng Weng   +5 more
wiley   +1 more source

Genetic variants in the ITPR2 gene are associated with Kashin‐Beck Disease in Tibetan

Molecular Genetics & Genomic Medicine, 2019
Background Kashin‐Beck Disease (KBD) is a chronic, endemic osteoarthropathy. Inositol 1,4,5‐triphosphate receptor type 2 (ITPR2) gene is involved in chondrocytes.
Xue He, Mei Bai, Ming Liu, Li Wang, Yongjun He, Hao Rong, Dongya Yuan, Tianbo Jin   +7 more
doaj   +1 more source

Theranostic scope of monometallic selenium and titanium dioxide nanoparticles in biomedicine: A review

Health Care Science, Volume 3, Issue 4, Page 215-231, August 2024.
The nanoparticles (NPs) of metals and metal oxides constitute significant components of technology in terms of monometallic NPs (MNPs). Throughout the last 10 years, the most fascinating and in‐depth uses of NPs have been found in the biomedical field, which has demonstrated the therapeutic potential of these particles. Significant strides were made in
Shwetha B. Nagarajan, Anuradha Jayaraman, Sanjeevi Ramakrishnan   +2 more
wiley   +1 more source