Results 51 to 60 of about 1,046 (117)

Oxidative Stress in Rheumatic and Musculoskeletal Diseases: A Meta‐Analysis

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Rheumatic and musculoskeletal diseases (RMDs) impose substantial burdens, while effective prevention and management remain limited by an incomplete understanding of their underlying mechanisms. Chronic inflammation and immune dysregulation are central features of many RMDs, and oxidative stress has been implicated in these processes. However,
Cong Lu, Jie Wei, Chao Zeng, Guanghua Lei, Yilun Wang, Ning Wang, Jasbir Arora   +6 more
wiley   +1 more source

The Silent Shift: Investigating Selenium Biovolatilization in Natural Environments

Reviews of Geophysics, Volume 63, Issue 4, December 2025.
Abstract Selenium (Se) is essential for human health. Organisms produce volatile Se through metabolism, which is an essential but hidden component of the Se geochemical cycle. Understanding this natural cycle is vital for sustainable development and ecosystem protection, thereby preserving planetary health and fostering harmonious coexistence between ...
Ruixuan Zhang, Xiaoping Wang, Yunqiao Zhou, Lei Chai, Jiamin Zeng, Li Xu   +5 more
wiley   +1 more source

Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis

International Journal of Endocrinology, 2014
Here, we sought to establish an experimental autoimmune thyroiditis rat model induced by bovine thyroglobulin (bTg) injection and to investigate pathological changes and variations in serum interferon-γ-inducible protein of 10 kDa (IP-10) in thyroid ...
Si-lu Cui, Jun Yu, Liu Shoujun
doaj   +1 more source

Ictal Asystole in a Patient With DEE due to an FGF12 Pathogenic Variant: A Reminder to Monitor Cardiac Function

Clinical Genetics, Volume 108, Issue 4, Page 486-487, October 2025.
We report the first known case of a 9‐year‐old male with early‐onset epilepsy, syncope, and ictal asystole–requiring pacemaker implantation at the age of seven–associated with a pathogenic variant in FGF12.
Johanne Piotrowski, Élise Schaefer, Michael Kuntz, Virginie Bois, Franz Schieffer, Laurence Jesel, Margaux Biehler, Anne De Saint Martin, Sarah Baer   +8 more
wiley   +1 more source

New Glycoconjugates Containing Selenium and Polyphenols. Stereoselective Synthesis by Pummerer‐like Rearrangement.

European Journal of Organic Chemistry, Volume 28, Issue 26, July 12, 2025.
Two series of novel six‐membered Se‐glycoconjugates containing hydroxycinnamic acids marked by well‐known antioxidant properties are synthesized, exploiting a Mitsunobu reaction and a Pummerer‐like rearrangement. A first example of six‐membered selenosugar with selenium in the ring and bearing an acetal‐like functional group at C‐1 was reported, which ...
Claudia González, Mauro De Nisco, Reinier Lemos, Giovanna Cimmino, Yoana Pérez‐Badell, Severina Pacifico, Silvana Pedatella   +6 more
wiley   +1 more source

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.
Sumaira Anjum, Mariam Hashim, Maham Imran, Sundus Babur, Sanniah Adnan, Christophe Hano, Wisam Nabeel Ibrahim   +6 more
wiley   +1 more source

Arthroscopic Ankle Arthrodesis for Treating Osteoarthritis in a Patient with Kashin-Beck Disease

Case Reports in Medicine, 2014
Kashin-Beck disease (KBD) is an endemic degenerative osteoarthritis. Death of cartilage and growth plate is the pathologic feature; therefore, KBD involves skeletal deformity and often results in osteoarthritis.
Kenjiro Iwasa, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka   +6 more
doaj   +1 more source

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 6, Page 1604-1619, June 2025.
(A) The risk factors associated with OA development. (B) Exosomes derived from TNF‐α stimulate upregulation of LRP1 levels in IPFP‐MSC‐derived exosomes, thereby exerting chondroprotective effects. (C) The regulation of endocytosis by LRP1, which impacts chondrocyte proliferation and apoptosis.
Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen   +8 more
wiley   +1 more source

Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis

Scientific Reports, 2017
Kashin-Beck disease (KBD) is a chronic osteochondropathy with unclear pathogeny. In this study, we compared the microRNA expression profiles of 16 KBD patients, 16 osteoarthritis (OA) patients and 16 rheumatoid arthritis (RA) patients and 16 healthy ...
Wenhong Wu, Awen He, Yan Wen, Xiao Xiao, Jingcan Hao, Feng Zhang, Xiong Guo   +6 more
doaj   +1 more source

Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.

PLoS ONE, 2013
BackgroundKashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD.ObjectiveTo investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699),
Lulin Huang, Yi Shi, Fang Lu, Hong Zheng, Xiaoqi Liu, Bo Gong, Jiyun Yang, Ying Lin, Jing Cheng, Shi Ma, He Lin, Zhenglin Yang   +11 more
doaj   +1 more source