Results 11 to 20 of about 10,432,347 (134)

The Long‐term Efficacy of Total Knee Arthroplasty on End‐stage Kashin–Beck Disease of the Knee in Highland Tibetan Areas Patients: A Retrospective Study with 10‐Year Follow‐up [PDF]

Orthopaedic Surgery
Objective Despite the established success of total knee arthroplasty (TKA) with end‐stage osteoarthritis, there is a notable scarcity of research on its long‐term outcomes in individuals suffering from end‐stage Kashin–Beck disease (KBD).
Haocheng Sun, Yahao Lai, Zichuan Ding, Yongrui Cai, Zeyu Luo, Zongke Zhou   +5 more
doaj   +4 more sources

A study on atypical Kashin–Beck disease: an endemic ankle arthritis [PDF]

Journal of Orthopaedic Surgery and Research, 2023
Background To study the epidemiological characteristics of atypical Kashin–Beck disease cases without characteristic hand lesions such as interphalangeal joint enlargement and brachydactyly and the characteristics of ankle joint lesions.
Fang Qi, Si-Lu Cui, Bing Zhang, Hao-Nan Li, Jun Yu   +4 more
doaj   +3 more sources

Effects of selenium and iodine on Kashin-Beck disease: an updated review [PDF]

Frontiers in Nutrition
Kashin-Beck disease (KBD) is an endochondral osteogenesis disorder characterised by epiphysis damage and secondary deformable arthropathy induced by multiple external factors, among which selenium (Se) and iodine deficiency are important influencing ...
Lin Liu, Pan Luo, Pengfei Wen, Peng Xu
doaj   +3 more sources

Untargeted Metabolomics Approach Correlated Enniatin B Mycotoxin Presence in Cereals with Kashin–Beck Disease Endemic Regions of China [PDF]

Toxins, 2023
Kashin–Beck disease (KBD) is a multifactorial endemic disease that only occurs in specific Asian areas. Mycotoxin contamination, especially from the Fusarium spp., has been considered as one of the environmental risk factors that could provoke ...
Danlei Sun, Camille Chasseur, Françoise Mathieu, Jessica Lechanteur, Pierre Van Antwerpen, Joanne Rasschaert, Véronique Fontaine, Cédric Delporte   +7 more
doaj   +3 more sources

Detection of selenoprotein transcriptome in chondrocytes of patients with Kashin–Beck disease [PDF]

Frontiers in Cell and Developmental Biology, 2023
Background: Kashin–Beck disease (KBD) is a deformed osteochondral disease with a chronic progression that is restrictively distributed in eastern Siberia, North Korea, and some areas of China, and selenium deficiency has been identified as an important ...
Yi Gong, Yifan Wu, Yanli Liu, Sijie Chen, Feiyu Zhang, Feihong Chen, Chaowei Wang, Shujin Li, Minhan Hu, Ruitian Huang, Ke Xu, Xi Wang, Lei Yang, Yujie Ning, Cheng Li, Rong Zhou, Xiong Guo, Xiong Guo   +17 more
doaj   +3 more sources

Identification of energy metabolism and m6A-related gene clusters in Kashin-Beck disease based on bioinformatics analysis [PDF]

BMC Musculoskeletal Disorders
Kashin-Beck disease (KBD) is a chronic and debilitating osteoarthropathy predominantly affecting populations in certain endemic regions. Despite extensive research, the underlying mechanisms of KBD remain poorly understood.
Ao Zhou, Ji Wang, An Jia, Qi Zhang, Zeren Duoji, Zhengqiang Yu, Zhiyong Huang   +6 more
doaj   +3 more sources

Transcriptome‐wide RNA m6A methylation profiles in an endemic osteoarthropathy, Kashin‐Beck disease [PDF]

Journal of Cellular and Molecular Medicine, Volume 28, Issue 20, October 2024.
Abstract Kashin‐Beck disease (KBD) is a chronic degenerative, disabling disease of the bones and joints and its exact aetiology and pathogenesis remain uncertain. This study is to investigate the role of m6A modification in the pathogenesis of KBD. Combined analysis of m6A MeRIP‐Seq and RNA‐Seq were used to analyse human peripheral blood samples from ...
Qian Zhang, Xiaodong Yang, Xingxing Deng, Hui Niu, Yijun Zhao, Jinfeng Wen, Sen Wang, Huan Liu, Xiong Guo, Cuiyan Wu   +9 more
wiley   +3 more sources

Identification of cell-specific epigenetic patterns associated with chondroitin sulfate treatment response in an endemic arthritis, Kashin-Beck disease [PDF]

Bone & Joint Research
Aims: To assess the alterations in cell-specific DNA methylation associated with chondroitin sulphate response using peripheral blood collected from Kashin-Beck disease (KBD) patients before initiation of chondroitin sulphate treatment.
Bolun Cheng, Cuiyan Wu, Wenming Wei, Hui Niu, Yan Wen, Cheng Li, Ping Chen, Hong Chang, Zhengjun Yang, Feng Zhang   +9 more
doaj   +3 more sources

Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin–Beck Disease [PDF]

Depression and Anxiety, Volume 2025, Issue 1, 2025.
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable research has been conducted in KBD patients. Methods: We conducted a field investigation in KBD areas in Northwest
Ye Liu, Yan Wen, Zhengjun Yang, Ruixue Zhou, Jingni Hui, Cheng Li, Gangyao Xu, Chan Liu, Huan Liu, Bolun Cheng, Yumeng Jia, Xianni Guo, Feng Zhang, Ruhai Bai   +13 more
wiley   +3 more sources

Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China [PDF]

Arthritis Research & Therapy, 2022
Background Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.
Yujie Ning, Minhan Hu, Yi Gong, Ruitian Huang, Ke Xu, Sijie Chen, Feiyu Zhang, Yanli Liu, Feihong Chen, Yanhai Chang, Guanghui Zhao, Cheng Li, Rong Zhou, Mikko J. Lammi, Xiong Guo, Xi Wang   +15 more
doaj   +3 more sources