Results 1 to 10 of about 12,699 (183)
International Journal of Infectious Diseases, 2022 Purpose: Indonesia is ranked as the fifth highest case of MDR TB in the world. MDR TB occurs due to resistance to Rifampicin and INH drugs caused by mutations in the M.Tb gene.
A. Fathurrachman +2 more
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Structure - Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis
Journal of Pure and Applied Microbiology, 2017 Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan Purkan +4 more
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Two Novel katG Mutations Conferring Isoniazid Resistance in Mycobacterium tuberculosis
Frontiers in Microbiology, 2020 Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is among the top 10 leading causes of death worldwide. The treatment course for TB is challenging; it requires antibiotic administration for at least 6 months, and bacterial ...
Li-Yu Hsu +13 more
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Туберкулез и болезни лёгких, 2016 51 patients suffering from pulmonary tuberculosis with concurrent HIV infection (Group 1) had PCR testing in real time (ZAO Sintol, Moscow) of sputum samples in order to study the spectrum and prevalence of mutations in katG, inhA, rpoB genes coding drug
T. Yu. Salina +2 more
doaj +3 more sources
Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315. [PDF]
PLoS ONE, 2015 An important aim for improving TB treatment is to shorten the period of antibiotic therapy without increasing relapse rates or encouraging the development of antibiotic-resistant strains. In any M.
Rose E Jeeves +13 more
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Indonesian Journal of Biotechnology, 2014 Mycobacterium tuberculosis resistant strains is a matter of great concern for TB control Program since no cure for some multi drug resistance TB (MDR-TB) cases.
Ning Rintiswati, P. Praseno
doaj +3 more sources
CRISPR-Cas9-based electrochemical biosensor for the detection of katG gene mutations in isoniazid-resistant tuberculosis [PDF]
ADMET and DMPKBackground and purpose: Multidrug-resistant tuberculosis (MDR-TB) remains a significant challenge in tuberculosis (TB) treatment, driven by simultaneous mutations in the rpoB and katG genes that confer resistance to rifampicin and isoniazid.
Dika Apriliana Wulandari +6 more
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Zhongguo shiyan zhenduanxue, 2017 目的分析吉林省耐多药结核分枝杆菌临床分离株rpoB、katG基因突变特点,为建立本省快速耐多药检测方法提供参考。方法对吉林省耐多药结核分枝杆菌菌株扩增rpoB、katG基因测序后比对分析。结果耐多药结核分枝杆菌rpoB、katG基因的突变率分别为83.53%和70.6%,突变类型包括点突变、联合突变和缺失。在rpoB基因中,82.30%突变发生在RRDR区域,最常见突变位点为rpoB 531、rpoB 526、rpoB 516。KatG基因突变率为70.6%,最常见突变位点为katG315 ...
张炜煜 +4 more
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Uncovering the structural impact of KatG Ser315 mutations in Mycobacterium tuberculosis via cryo-EM. [PDF]
Protein SciAllport T, Chaplin AK.
europepmc +3 more sources
Journal of Pure and Applied Microbiology, 2021 Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine
Neetha S Murthy +8 more
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