Results 91 to 100 of about 12,768 (245)

Rational Design and Antimycobacterial Evaluation of Aryl Sulfonamide–Linked Isoniazid Hydrazones Against Mycobacterium Tuberculosis

ChemMedChem, Volume 20, Issue 21, November 6, 2025.
Molecular docking shows that ligands 8 (a–i) adopt a U‐shaped geometry in the InhA active site, enabling stronger interactions than 7 (j–r). Surprisingly, both sets display similar potency, indicating that factors like electronic effects or solvation also influence anti‐TB activity.
Mukanda Gedeon Kadima, Sahil Mishra, Gobind Kumar, Pule Seboletswe, Afsana Kajee, Ankit, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Rajshekhar Karpoormath, Parvesh Singh   +10 more
wiley   +1 more source

Involvement of catalase and superoxide dismutase in hydrophobic organic solvent tolerance of Escherichia coli

AMB Express, 2021
Escherichia coli strains are generally sensitive to hydrophobic organic solvents such as n-hexane and cyclohexane. Oxidative stress in E. coli by exposure to these hydrophobic organic solvents has been poorly understood. In the present study, we examined
Noriyuki Doukyu, Katsuya Taguchi
doaj   +1 more source

_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance [PDF]

, 2008
Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Karthik Raman, Nagasuma Chandra
core   +1 more source

Viewpoint: Scientific dogmas, paradoxes and mysteries of latent Mycobacterium tuberculosis infection [PDF]

, 2011
Worldwide, there are nearly 10 million new cases of active TB and 1.8 million associated deaths every year. WHO estimates that one-third of the world’s population is infected with Mycobacterium tuberculosis (Mtb), forming a huge latent Mtb global ...
Argyrou, Balasubramanian, Behar, Biketov, Corbett, Ehlers, Fraser, Grange, Henderson, Hernández-Pando, Honaker, Kang, Lin, Lobue, Mack, Marais, Migliori, Mitchison, Neyrolles, Opie, Parris, Stanford, Sterling, Sudre, Timmins, Vilchèze, WHO, WHO Report   +27 more
core   +1 more source

Contrasting Effects of Probiotic Yogurt and Brown Yogurt on the Urinary Metabolites and Gut Microbial Function of Healthy Adults

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
We identified differing metabolic responses to different types of yogurt. Brown yogurt mainly modulated pathways associated with human and gut microbial ammonia metabolism, whereas probiotic yogurt mainly affected amino acid metabolism. ABSTRACT Consuming yogurt is beneficial for healthy people, but few studies have evaluated the interactions among ...
Si Ting Chen, Tie Min Jiang, Yu Chun Wang, Xia Qi Xiong, Jun Ying Zhao, Li Jun Chen   +5 more
wiley   +1 more source

Predictive identification and design of potent inhibitors targeting resistance-inducing candidate genes from E. coli whole-genome sequences

Frontiers in Bioinformatics
Introduction: This work utilizes predictive modeling in drug discovery to unravel potential candidate genes from Escherichia coli that are implicated in antimicrobial resistance; we subsequently target the gidB, MacB, and KatG genes with some compounds ...
Abdullahi Tunde Aborode, Neeraj Kumar, Christopher Busayo Olowosoke, Christopher Busayo Olowosoke, Tope Abraham Ibisanmi, Islamiyyah Ayoade, Islamiyyah Ayoade, Haruna Isiyaku Umar, Haruna Isiyaku Umar, Abdullahi Temitope Jamiu, Basit Bolarinwa, Zainab Olapade, Abidemi Ruth Idowu, Ibrahim O. Adelakun, Isreal Ayobami Onifade, Benjamin Akangbe, Modesta Abacheng, Odion O. Ikhimiukor, Aeshah A. Awaji, Ridwan Olamilekan Adesola   +19 more
doaj   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Molecular analysis of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from India [PDF]

, 2008
The presence of mutations in specific regions of katG, inhA, oxyR–ahpC and kasA associated with isoniazid (INH)-resistant clinical isolates of Mycobacterium tuberculosis from India were analysed by DNA sequencing.
Narayanan, P R, Nusrath Unissa, A, Selvakumar, N, Sujatha, Narayanan   +3 more
core   +1 more source

DETEKSI Mycobacterium tuberculosis DARI KULTUR MGIT BERDASARKAN GEN katG

Journal of Indonesian Medical Laboratory and Science (JoIMedLabS), 2020
Tuberkulosis (TB) merupakan penyakit infeksi pada saluran pernapasan yang disebabkan oleh Mycobacterium tuberculosis. Saat ini banyak ditemukan galur M.tuberculosis yang resisten terhadap dua atau lebih obat anti tuberculosis (OAT) yang dikenal sebagai galur Multi Drugs Resistance M.tuberculosis (MDR-MTB).
Prima Nanda Fauziah, Sitti Romlah, Arif Khozinul Asrori   +2 more
openaire   +2 more sources

Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians [PDF]

, 2003
A large number (265) of burials from 1731-1838 were discovered in sealed crypts of the Dominican Church, Vac, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available.
Donoghue, HD, Fletcher, HA, Holton, J, Pap, I, Spigelman, M   +4 more
core