Results 101 to 110 of about 12,768 (245)

Design, synthesis and biologival evaluation of novel isoniazid derivatives with potente antitubercular activity [PDF]

, 2014
The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been driving the scientific community to urgently search for new and efficient antitubercular drugs.
Aires-de-Sousa, João, Correia, Henrique E., Elvas Leitao, Ruben, Kovalishyn, Vasyl, Latino, Diogo A. R. S., Martins, Filomena, Miranda, Vanessa, Ramos, Jorge, Reis, Marina, Santos, Lídia, Santos, Susana, Ventura, Cristina, Vitorino, Susana, Viveiros, Miguel   +13 more
core   +1 more source

Rationally Designed InhA Inhibitors: A Comparative Anti‐Tubercular Activity Study of Sulfonate Esters of Isoniazid Hydrazones and Their Structurally Flexible Benzyl Analogues

Chemical Biology &Drug Design, Volume 106, Issue 3, September 2025.
A comparative anti‐tubercular evaluation of sulfonate esters of isoniazid hydrazones and their structurally flexible benzyl analogues disclosed several potent compounds against Mycobacterium tuberculosis with the representative compound displaying an MIC of 0.078 μg/mL.
Mukanda Gedeon Kadima, Sahil Mishra, Gobind Kumar, Pule Seboletswe, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Rajshekhar Karpoormath, Parvesh Singh   +8 more
wiley   +1 more source

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

Nature Communications
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase.
XinYue Wang, William J. Jowsey, Chen-Yi Cheung, Caitlan J. Smart, Hannah R. Klaus, Noon EJ Seeto, Natalie JE Waller, Michael T. Chrisp, Amanda L. Peterson, Boatema Ofori-Anyinam, Emily Strong, Brunda Nijagal, Nicholas P. West, Jason H. Yang, Peter C. Fineran, Gregory M. Cook, Simon A. Jackson, Matthew B. McNeil   +17 more
doaj   +1 more source

Optimasi Pcr (Polymerase Chain Reaction) Fragmen 724 Pb Gen Katg Multi Drug Resistance Tuberculosis Untuk Meningkatkan Produk Amplifikasi [PDF]

, 2013
Deteksi adanya mutasi pada gen katG MDR-TB (Multi Drug Resistance Tuberculosis) yang bertanggung jawab terhadap resistensi isoniazid (INH) dapat dilakukan dengan teknik Polymerase Chain Reaction (PCR).
C, Y. S. (Yowani), K, R. (Ratnayani), W, D. N. (Deniariasih)   +2 more
core  

Metabolic evolution and the self-organization of ecosystems [PDF]

, 2017
Metabolism mediates the flow of matter and energy through the biosphere. We examined how metabolic evolution shapes ecosystems by reconstructing it in the globally abundant oceanic phytoplankter Prochlorococcus To understand what drove observed ...
Abdul-Rahman, Bagby, Bateson, Benitez-Nelson, Bertlisson, Biddanda, Button, Cermak, Eiler, Goericke, Hartmann, Kieber, Kulk, Leboulanger, Lenton, Mackey, Mella-Flores, Michael J. Follows, Och, Partensky, Reinhard, Robbins, Roe, Rogier Braakman, Russell, Ryan, Sallie W. Chisholm, Van Valen, West, Yuan, Zorz   +30 more
core   +1 more source

Old Pathogens–New Patient Types: Infections in a CAR T‐Cell Recipient. Could It Get Any More Complicated?

Transplant Infectious Disease, Volume 27, Issue 5, September/October 2025.
ABSTRACT The case discussed involves a 41‐year‐old Italian man who was a candidate for chimeric antigen receptor T‐cell therapy (CAR‐T) for mediastinal diffuse large B‐cell lymphoma. His CAR‐T treatment was postponed several times due to prolonged relapsing COVID‐19 and new onset of pulmonary Mycobacterium tuberculosis diseases.
Monica Melchio, Joshua A. Hill, Maunank Shah, Dionysios Neofytos, Massimiliano Gambella, Anna Maria Raiola, Emanuele Delfino, Elisa Balletto, Emanuele Angelucci, Matteo Bassetti, Malgorzata Mikulska   +10 more
wiley   +1 more source

Noninvasive Determination of 2-[18F]-Fluoroisonicotinic Acid Hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis-Infected Mice [PDF]

, 2014
Tuberculosis (TB) is a global pandemic requiring sustained therapy to facilitate curing and to prevent the emergence of drug resistance. There are few adequate tools to evaluate drug dynamics within infected tissues in vivo.
Hooker, Jacob M, Jain, S. K., Liu, L., Ordonez, A. A., Tonge, P. J., Wang, H., Weinstein, E. A.   +6 more
core   +1 more source

Plastoquinone redox status influences carboxysome integrity via a RpaA‐ and reactive oxygen species‐dependent regulatory network

The Plant Journal, Volume 123, Issue 6, September 2025.
SUMMARY Carboxysomes are bacterial microcompartments that encapsulate Rubisco and are a core component of the cyanobacterial carbon concentration mechanism (CCM). While carboxysome number, size, and spatial organization vary in different environmental conditions (CO2, light availability, redox state, temperature, and light quality), the molecular ...
María Santos‐Merino, Lauri Nikkanen, Emmanuel J. Kokarakis, Yagut Allahverdiyeva, Daniel C. Ducat   +4 more
wiley   +1 more source

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy

Microbiology Spectrum
The incidence of isoniazid (INH) resistant Mycobacterium tuberculosis is increasing globally. This study aimed to identify the molecular mechanisms behind the development of INH resistance in M.
Ketema Tafess, Timothy Ting-Leung Ng, Kingsley King-Gee Tam, Kenneth Siu-Sing Leung, Jake Siu-Lun Leung, Lam-Kwong Lee, Hiu Yin Lao, Chloe Toi-Mei Chan, Wing-Cheong Yam, Samson Sai Yin Wong, Terrence Chi-Kwong Lau, Gilman Kit-Hang Siu   +11 more
doaj   +1 more source

Molecular characterization of Mycobacterium tuberculosis strains resistant to isoniazid

International Journal of Mycobacteriology, 2016
Objective/background: Tuberculosis is a major public health problem and the emergence of drug resistance complicates the situation even more. It is therefore crucial to implement all conclusions from the studies that aim at a better understanding of the ...
Salma Smaoui, Mariem Siala, Sondes Hadj Fredj, Sana Kammoun, Chema Marouane, Salma Hachicha, Asma Ghorbel, Radhouane Gdoura, Leila Slim, Taieb Ben Messaoud, Férièle Messadi   +10 more
doaj   +1 more source