Results 111 to 120 of about 12,768 (245)

High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations [PDF]

, 2017
Objectives The purpose of this study was to determine the levels of isoniazid and ethionamide resistance and to identify associated mutations in endemic multidrug-resistant (MDR) strains of Mycobacterium tuberculosis from the Lisbon metropolitan area ...
Boettger, Erik C., Couto, Isabel, Machado, Diana, Perdigão, João, Portugal, Isabel, Ramos, Jorge, Ritter, Claudia, Viveiros, Miguel   +7 more
core  

Accurate and effective multidrugresistant Mycobacterium tuberculosis detection method using gap-filling ligation coupled with high-resolution capillary electrophoresis-based single strand conformation polymorphism [PDF]

, 2017
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Cho, E., Choi, W., Jung, G.Y., Lee, J.
core   +1 more source

Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

Frontiers in Microbiology, 2018
The emergence of strains of Mycobacterium tuberculosis resistant to isoniazid (INH) has underscored the need for the development of new anti-tuberculosis agents.
Bruno L. Abbadi, Bruno L. Abbadi, Valnês da Silva Rodrigues-Junior, Adilio da Silva Dadda, Adilio da Silva Dadda, Kenia Pissinate, Anne D. Villela, Maria M. Campos, Maria M. Campos, Luiz G. de França Lopes, Cristiano V. Bizarro, Cristiano V. Bizarro, Pablo Machado, Pablo Machado, Eduardo H. S. Sousa, Luiz A. Basso, Luiz A. Basso, Luiz A. Basso   +17 more
doaj   +1 more source

Mutations of katG and inhA in MDR M. tuberculosis

Tuberculosis and Respiratory Diseases, 2007
Backgrounds: Mutations of katG and inhA (ORF and promoter) are known to be related to isoniazid (INH) resistance of Mycobacterium tuberculosis. Because reports on these mutations in Korean isolates are limited (i.e. only the frequency of katG codon 463 was evaluated.), we tried to know the kinds of mutations of two genes and their frequencies in INH ...
Hai Hua Lin, Hee-Youn Kim, Yeo-Jun Yun, Chan Geun Park, Bum-Joon Kim, Young-Gil Park, Yoon-Hoh Kook   +6 more
openaire   +1 more source

The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China

Emerging Microbes and Infections, 2018
Whole-genome sequencing was used to analyze the profiles of isoniazid (INH) resistance-related mutations among 188 multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and mono-INH-resistant isolates collected in a recent Chinese national ...
Liguo Liu, Fengting Jiang, Lihong Chen, Bing Zhao, Jie Dong, Lilian Sun, Yafang Zhu, Bo Liu, Yang Zhou, Jian Yang, Yanlin Zhao, Qi Jin, Xiaobing Zhang   +12 more
doaj   +1 more source

Effective pragmatic approach of diagnosis of multidrug-resistant tuberculosis by high-resolution melt curve assay

International Journal of Mycobacteriology, 2018
Background: Effective management of multidrug-resistant tuberculosis (MDR-TB) requires cost-effective and rapid screening of rifampicin (RIF) and isoniazid (INH) resistance.
Sanjay Singh Negi, Priyanka Singh, Anudita Bhargava, Sachin Chandrakar, Ujjwala Gaikwad, Padma Das, Ajoy Behra   +6 more
doaj   +1 more source

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study [PDF]

, 2017
Objectives Treatment outcome of MDR-TB is critically dependent on the proper use of second-line drugs as per the result of in vitro drug susceptibility testing (DST).
Böttger, E. C., Cambau, E., Cirillo, D. M., Hoffner, S., Machado, D., Matthys, V., Perez Del Molino, M. L., Raskine, L., Richter, E., Ritter, C., Tortoli, E., van Soolingen, D., Viveiros, M.   +12 more
core  

The role of alternative sigma factor S (σS) and sigma factor B (σB) in bacterial cell stress response and their regulation [PDF]

, 2014
Bacteria successfully take possession of almost every recess of the earth. However bacteria can be liable to big changes of environmental conditions in every settled biotope. Some of them living in a high specializated medium do not show usually ability
Bielecki, Stanisław, Opęchowska, Marzena   +1 more
core  

Effect of Oxidative Stress on AhpC Activity and Virulence in katG Ser315 Thr Mycobacterium tuberculosis Mutant

Indonesian Journal of Biotechnology, 2015
Mycobacterium tuberculosis strains resistance to INH is mainly caused by the alteration in several genesencoding the molecular targets. Mutation of katG at codon 315 especially Ser315Thr are responsible forINH resistance in a large proportion of TB cases.
Ning Rintiswati, Tri Wibawa, Widya Asmara, Hardyanto Soebono   +3 more
doaj  

High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.

PLoS ONE, 2015
BackgroundDrug-resistant tuberculosis (TB) remains extremely difficult to treat because there are often few remaining active medications and limited diagnostic options to detect resistance.
Abraham J Niehaus, Koleka Mlisana, Neel R Gandhi, Barun Mathema, James C M Brust   +4 more
doaj   +1 more source