Results 11 to 20 of about 12,768 (245)

Oxidative Stress Detection With Escherichia Coli Harboring A katG\u27::lux Fusion [PDF]

Applied and Environmental Microbiology, 1996
A plasmid containing a transcriptional fusion of the Escherichia coli katG promoter to a truncated Vibrio fischeri lux operon (luxCDABE) was constructed. An E.
Belkin, S., LaRossa, R. A., Smulski, D. R., Van Dyk, T. K., Vollmer, Amy Cheng   +4 more
core   +5 more sources

Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis [PDF]

Trends in Microbiology, 2019
A peptidomimetic containing a thiazolo ring-fused 2-pyridone (C10) has now been reported to inhibit hypoxia-induced tolerance to isoniazid (INH) in Mycobacterium tuberculosis (Flentie et al., Proc. Natl. Acad. Sci. U. S. A., 2019). The C10 compound could also potentiate the bactericidal activity in aerobically grown bacilli, prevented selection of drug-
Pablo Machado, Cristiano Valim Bizarro, Luiz Augusto Basso   +2 more
openalex   +3 more sources

Comparative study of catalase-peroxidases (KatGs) [PDF]

Archives of Biochemistry and Biophysics, 2008
Catalase-peroxidases or KatGs from seven different organisms, including Archaeoglobus fulgidus,Bacillus stearothermophilus, Burkholderia pseudomallei, Escherichia coli, Mycobacterium tuberculosis, Rhodobacter capsulatus and Synechocystis PCC 6803, have been characterized to provide a comparative picture of their respective properties. Collectively, the
Rahul, Singh, Ben, Wiseman, Taweewat, Deemagarn, Vikash, Jha, Jacek, Switala, Peter C, Loewen   +5 more
openaire   +2 more sources

Catalase-peroxidases (KatG) Exhibit NADH Oxidase Activity [PDF]

Journal of Biological Chemistry, 2004
Catalase-peroxidases (KatG) produced by Burkholderia pseudomallei, Escherichia coli, and Mycobacterium tuberculosis catalyze the oxidation of NADH to form NAD+ and either H2O2 or superoxide radical depending on pH. The NADH oxidase reaction requires molecular oxygen, does not require hydrogen peroxide, is not inhibited by superoxide dismutase or ...
Rahul, Singh, Ben, Wiseman, Taweewat, Deemagarn, Lynda J, Donald, Harry W, Duckworth, Xavi, Carpena, Ignacio, Fita, Peter C, Loewen   +7 more
openaire   +2 more sources

KatG from Salmonella Typhimurium is a peroxynitritase [PDF]

FEBS Letters, 2010
Pathogenic bacteria elicit protective responses to oxidative and nitrosative stresses. Although such responses are generally distinct, it was recently reported in Mycobacterium tuberculosis that catalase–peroxidase (KatG), a classical defence against peroxides, also exhibits peroxynitritase activity.
McLean, Samantha, Bowman, Lesley A.H., Poole, Robert K.   +2 more
openaire   +2 more sources

Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2023
Background: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance.
Senamile Lale Ngema, Navisha Dookie, Rubeshan Perumal, Louansha Nandlal, Nikita Naicker, Marothi Peter Letsoalo, Max O'Donnell, Azraa Khan, Nesri Padayatchi, Kogieleum Naidoo   +9 more
doaj   +1 more source

Coordinated interaction between Lon protease and catalase-peroxidase regulates virulence and oxidative stress management during Salmonellosis

Gut Microbes, 2022
This study investigates the interplay between Lon protease and catalase-peroxidase (KatG) in relation to virulence modulation and the response to oxidative stress in Salmonella Typhimurium (ST).
Perumalraja Kirthika, Vijayakumar Jawalagatti, Amal Senevirathne, John Hwa Lee   +3 more
doaj   +1 more source

Immunogenicity assay of KatG protein from Mycobacterium tuberculosis in mice: preliminary screening of TB vaccine [PDF]

The Ukrainian Biochemical Journal, 2018
The tuberculosis (TB) disease is still widely found even though BCG vaccine given to many people. Ineffectiveness of the BCG vaccine is one of causes that make the difficulties in preventing TB transmission. Objective of the research was to determine the
P. Purkan, R. Budiyanto, R. Akbar, S. P. A. Wahyuningsih, W. Retnowati   +4 more
doaj   +1 more source

Nucleotide sequence of the Mycobacterium leprae katG region [PDF]

Journal of Bacteriology, 1997
Synthetic oligonucleotide primers based on the DNA sequence data of the Escherichia coli, Mycobacterium tuberculosis, and Mycobacterium intracellulare katG genes encoding the heme-containing enzyme catalase-peroxidase were used to amplify and analyze the Mycobacterium leprae katG region by PCR.
N, Nakata, M, Matsuoka, Y, Kashiwabara, N, Okada, C, Sasakawa   +4 more
openaire   +2 more sources

Pattern of InhA and KatG mutations in isoniazid monoresistant Mycobacterium tuberculosis isolates

Lung India, 2020
Aims and Objectives: The aim of the study is to detect the pattern of genetic mutation, i.e., Inh A or Kat G or both (Inh A and kat G) in isoniazid (INH) monoresistant mycobacteria and to correlate with the pattern in multidrug-resistant (MDR) isolates ...
Ashok Singh Charan, Neeraj Gupta, Ramakant Dixit, Piyush Arora, Tarun Patni, Kalliath Antony, Manisha Singh   +6 more
doaj   +1 more source