katG (SER 315 THR) Gene Mutation in Isoniazid Resistant Mycobacterium Tuberculosis
Kathmandu University Medical Journal, 2012 Background Isoniazid (INH) together with Rifampicin (RFP) forms the cornerstone of a short chemotherapy course for tuberculosis (TB) treatment. Mutation at codon 315 of katG gene is most prevalent in isoniazid resistant Mycobacterium tuberculosis (MTB) and is high in area with high TB incidence.
Sujan Babu Marahatta +10 more
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Three-Dimensional Model and Molecular Mechanism of Mycobacterium tuberculosis Catalase-Peroxidase (KatG) and Isoniazid-Resistant KatG Mutants [PDF]
Microbial Drug Resistance, 2004 Mycobacterium tuberculosis KatG enzyme functions both as catalase for removing hydrogen peroxide (H 2 O 2 ) and as peroxidase for oxidating isoniazid (INH) to active form of anti-tuberculosis drug. Although mutations in
L, Mo +7 more
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Mutation of katG in a clinical isolate of Mycobacterium tuberculosis: effects on catalase-peroxidase for isoniazid activation [PDF]
The Ukrainian Biochemical Journal, 2016 Mutations in katG gene are often associated with isoniazid (INH) resistance in Mycobacterium tuberculosis strain. This research was perfomed to identify the katG mutation in clinical isolate (L8) that is resistant to INH at 1 μg/ml.
Purkan, +5 more
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Non-lethal exposure to H2O2 boosts bacterial survival and evolvability against oxidative stress [PDF]
, 2020 Unicellular organisms have the prevalent challenge to survive under oxidative stress of reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). ROS are present as by-products of photosynthesis and aerobic respiration.
Eravci, Murat +7 more
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Scientific Reports, 2023 Resistance to isoniazid (INH) and rifampicin (RIF) first-line drugs in Mycobacterium tuberculosis (Mtb), together called multi-drug resistance, threatens tuberculosis control.
Gary Napier +3 more
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Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain [PDF]
, 2015 The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a
Balloux, Francois +6 more
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Journal of Pure and Applied Microbiology, 2019 Anti-tubercular therapy is one of the effective strategies used to control tuberculosis, so, a planned and accurate treatment regimen is of utmost importance, but number of cases are being treated as MDR on the basis of rifampicin mono resistance.
Sana Nudrat, Umar Farooq, Mazhar Maqsood
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The Pan African Medical Journal, 2017 INTRODUCTION: Tuberculosis remains the leading causes of death worldwide with frequencies of mutations in rifampicin and isoniazid resistant Mycobacterium tuberculosis isolates varying according to geographical location.
Faustinos Tatenda Takawira +4 more
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Role of KatG in Francisella tularensis Susceptibility to Resazurin.
Proceedings of the West Virginia Academy of Science, 2023 The CDC classifies Francisella tularensis as a Category A bioterrorism agent. Due to the risk of potential release of antibiotic-resistant F. tularensis strains, new therapeutics against F. tularensis must be developed. Resazomycins are resazurin (Rz)-based compounds that exhibit antimicrobial activity against F.
Rori Schreiber
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Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance. [PDF]
, 2018 Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available datasets describing its AMR characteristics demand disparate data-type analyses ...
Anand, Amitesh +11 more
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