Results 41 to 50 of about 12,768 (245)
International Journal of Medical Microbiology, 2021 Isoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level.
Flavio De Maio +7 more
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Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC. [PDF]
PLoS ONE, 2016 In the last decade, there were 10 million new tuberculosis cases per year globally. Around 9.5% of these cases were caused by isoniazid resistant (INHr) Mycobacterium tuberculosis (Mtb) strains.
Luisa Maria Nieto R +8 more
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Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL.
Meng-Yu Xia +5 more
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Presence of katG gene in resistant Mycobacterium tuberculosis. [PDF]
Journal of Clinical Pathology, 1996 It has been reported recently that isoniazid resistant strains of Mycobacterium tuberculosis have lost the katG gene which encodes the catalase-peroxidase enzyme. A 35 mer oligonucleotide probe specific for the katG gene of M tuberculosis, 3' end-labelled with digoxigenin, was constructed and hybridised with DNA extracted from 26 clinical isolates of M
M, Jaber, A, Rattan, R, Kumar
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Chronic Diseases JournalBACKGROUND: Isoniazid (INH) is one of the first-line drugs used for the treatment of Mycobacterium tuberculosis (Mtb). This study aimed to determine the mutations in katG and inhA promoter regions associated with INH resistance in clinical isolates of ...
Shahrzad Shafiei +2 more
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New Microbes and New Infections, 2021 Multidrug-resistant (MDR) Mycobacterium tuberculosis strains, defined as resistant to at least isoniazid and rifampin, have emerged as a major worldwide health threat. Spontaneous point mutations in various genes of M.
B. Motavaf +5 more
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KatG, the Bifunctional Catalase of Xanthomonas citri subsp. citri, Responds to Hydrogen Peroxide and Contributes to Epiphytic Survival on Citrus Leaves. [PDF]
PLoS ONE, 2016 Xanthomonas citri subsp. citri (Xcc) is the bacterium responsible for citrus canker. This bacterium is exposed to reactive oxygen species (ROS) at different points during its life cycle, including those normally produced by aerobic respiration or upon ...
María Laura Tondo +5 more
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Nucleotide sequence of katG, encoding catalase HPI of Escherichia coli [PDF]
Journal of Bacteriology, 1988 The gene katG, encoding catalase HPI of Escherichia coli, was sequenced, predicting a 726-amino-acid protein. The sequence was confirmed by identification of potential regulatory elements and amino acid sequencing of peptides. HPI shows no homology to other catalases. The distances between katG, metF, and ppc were defined.
B L, Triggs-Raine +4 more
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Microbiology Indonesia, 2010 Mycobacterium tuberculosis resistant to rifampin and isoniazid, known as multidrug-resistant M. tuberculosis (MDR-TB) strains, is an emerging problem of great importance to public health, with higher mortality rates than for drug-sensitive strains ...
HERA NOVIANA +3 more
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Heteroresistance of Mycobacterium tuberculosis in the Sputum Detected by Droplet Digital PCR
Biology, 2023 Heteroresistance in MTB refers to the presence of distinct subpopulations of bacteria with varying levels of antibiotic susceptibility within a population. Multidrug-resistant and rifampicin-resistant TB are serious global health concerns. In this study,
Ye Win Aung +4 more
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