Results 81 to 90 of about 12,768 (245)

Mycobacterium tuberculosis - the 10 years of epidemiological and diagnostics studies [PDF]

, 2005
Tuberculosis (ТВ) is the main bacterial pathogen that causes more deaths than AIDS, malaria and all infectious diseases. The unusual long doubling time (about 24h), highly hydrophobic cell envelope resistant to chemical lysis was the reason to delay ...
Boruń-Popławska, Marta, Brzostek, Anna, Dziadek, Jarosław, Sajduda, Anna   +3 more
core  

Diagnosis and management of drug-resistant tuberculosis in South African adults [PDF]

, 2014
Detection of drug-resistant tuberculosis (DR-TB) increases each year in South Africa (SA). Most cases result from airborne transmission of already resistant TB strains.
Hughes, J, Osman, M
core   +3 more sources

Characterization of the Catalase-Peroxidase KatG from Burkholderia pseudomallei by Mass Spectrometry [PDF]

Journal of Biological Chemistry, 2003
The electron density maps of the catalase-peroxidase from Burkholderia pseudomallei (BpKatG) presented two unusual covalent modifications. A covalent structure linked the active site Trp111 with Tyr238 and Tyr238 with Met264, and the heme was modified, likely by a perhydroxy group added to the vinyl group on ring I.
Donald, Lynda J., Krokhin, Oleg V., Duckworth, Harry W., Wiseman, Ben, Deemagarn, Taweewat, Singh, Rahul, Switala, Jack, Carpena, Xavi, Fita, Ignacio, Loewen, Peter C.   +9 more
openaire   +3 more sources

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Study of Immunological and Molecular Analysis of Virulence Genes in Mycobacterium tuberculosis Isolates from Hilla Teaching Hospital

Medical Journal of Babylon
Background: Despite the widespread use of a live attenuated vaccine and many medications, tuberculosis (TB), remains one of the top killers among infectious diseases.
Bashaar O. Jwaad, Morug S. Al-Rubee, Samara A. Alsalihi, Hadi F. Alyasari   +3 more
doaj   +1 more source

Role of metal-dependent regulation of ESX-3 secretion in intracellular survival of Mycobacterium tuberculosis [PDF]

, 2016
More people die every year from Mycobacterium tuberculosis infection than from infection by any other bacterial pathogen. Type VII secretion systems (T7SS) are used by both environmental and pathogenic mycobacteria to secrete proteins across their ...
Philips, Jennifer A, Portal-Celhay, Cynthia, Raynowska, Jenelle, Thompson, Victor, Tinaztepe, Emir, Wei, Jun-Rong   +5 more
core   +2 more sources

Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG [PDF]

Molecular Microbiology, 2001
In several bacteria, the catalase–peroxidase gene katG is under positive control by oxyR, a transcriptional regulator of the peroxide stress response. The Mycobacterium tuberculosis genome also contains sequences corresponding to oxyR, but this gene has been inactivated in the tubercle bacillus because of the presence of multiple mutations and ...
Zahrt, Thomas C., Song, Jian, Siple, Jessica, Deretic, Vojo   +3 more
openaire   +3 more sources

PGLYRP4 Enhances Shigella flexneri Virulence by Promoting virF Transcription via the CpxA/R Two‐Component System

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Shigella can use the host's innate immune system to optimize the expression of its virulence factors. The PGLYRP4 protein, a member of the host's innate immune system, increases VirF expression in Shigella by stimulating the CpxA/R TCS, thereby enhancing the expression of the virulence system.
Rita Trirocco, Gianni Prosseda
wiley   +1 more source

Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis. [PDF]

, 2017
Only 25% of multidrug-resistant tuberculosis (MDR-TB) cases are currently diagnosed. Line probe assays (LPAs) enable rapid drug-susceptibility testing for rifampicin (RIF) and isoniazid (INH) resistance and Mycobacterium tuberculosis detection.
Al-Mutairi, Asante-Poku, Asencios, Aung, Aurin, Bablishvili, Brossier, Bwanga, Causse, Chen, Claudia M. Denkinger, Fabre, Farooqi, Felkel, Gauthier, Gitti, Heifets, Huang, Imperiale, Kapata, Karen R. Steingart, Khadka, Kumar, Li, Macedo, Madhukar Pai, N'Guessan, Nwofor, Patrick G.T Cudahy, Raveendran, Rienthong, Ruvandhi R. Nathavitharana, Samuel G. Schumacher, Sangsayunh, Shubladze, Simons, Singhal, Sreevatsan, Telenti, Tho, Warren, Yadav, Yordanova   +42 more
core   +3 more sources

All‐Oral Shorter Treatment Regimens for Multidrug‐ and Rifampicin‐Resistant Tuberculosis: Evaluating Their Effectiveness, Safety, and Impact on the Quality of Life of Patients in Lao PDR

Tropical Medicine &International Health, Volume 30, Issue 12, Page 1340-1353, December 2025.
ABSTRACT Background Drug‐resistant tuberculosis remains a major public health challenge in Lao PDR, with low second‐line treatment uptake and suboptimal outcomes. To improve effectiveness, safety, and tolerability, a shorter all‐oral regimen for multidrug‐ and rifampicin‐resistant tuberculosis (MDR/RR‐TB) was introduced under the TDR Short, all‐Oral ...
Vibol Iem, Sakhone Suthepmany, Vongkham Inthavong, Anousone Sisouvanh, Khamloun Choumlivong, Kyung Hyun Oh, Philipp du Cros, Fatimata Bintou Sall, Corinne S. Merle, Jacques Sebert, Donekham Inthavong   +10 more
wiley   +1 more source