Results 1 to 10 of about 1,021 (156)
KCC2 downregulation facilitates epileptic seizures [PDF]
Scientific Reports, 2017 GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl−] concentration, which in adult depends on neuron specific K+-Cl− cotransporter-2 (KCC2).
Lulan Chen +6 more
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Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission [PDF]
The Journal of Neuroscience, 2006 The neuron-specific K+–Cl−cotransporter KCC2 extrudes Cl−and renders GABA and glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-dependent KCC2 activation is regulated at the transcriptional level and by unknown posttranslational mechanisms.
Peter Blaesse +7 more
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KCC2 escape from neuropathic pain [PDF]
Science-Business eXchange, 2013 Researchers from Laval University have described an activator of the co-transporter KCC2 and shown its analgesic effect in mice. The group is developing next-generation compounds with better pharmacological properties.
Benjamin Boettner
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Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons [PDF]
Neural Plasticity, 2011 The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons.
Anastasia Ludwig +7 more
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Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity [PDF]
Frontiers in Cellular Neuroscience, 2019 The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift during development.
Etienne Côme +4 more
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KCC2 function modulates in vitro ictogenesis [PDF]
Neurobiology of Disease, 2015 GABAA receptor-mediated inhibition is active and may contribute to epileptiform synchronization. The efficacy of inhibition relies on low levels of intracellular Cl−, which are controlled by KCC2 activity.
Shabnam Hamidi, Massimo Avoli
doaj +4 more sources
Frontiers in Cellular Neuroscience, 2023 K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Abhishek Pethe +7 more
doaj +3 more sources
iScience, 2022 Summary: Modulation of the neuronal K+/Cl− cotransporter 2 (KCC2) activity, which mediates Cl− export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an ...
Hila Asraf +5 more
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The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology [PDF]
Frontiers in Physiology, 2022 The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu +48 more
doaj +2 more sources
Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function [PDF]
Frontiers in Neurology, 2020 As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu +13 more
doaj +4 more sources