Development of KCC2 therapeutics to treat neurological disorders [PDF]
Frontiers in Molecular NeuroscienceKCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS.
Shilpa D. Kadam, Shane V. Hegarty
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KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q [PDF]
Frontiers in Molecular NeuroscienceIntroductionThe potassium chloride co-transporter 2 (KCC2) is the principal Cl− extrusion mechanism employed by mature neurons in the central nervous system (CNS) and plays a critical role in determining the efficacy of fast synaptic inhibition mediated ...
Jinglin Ji +5 more
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Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus [PDF]
Frontiers in Cellular Neuroscience, 2011 The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus.
Ilgam eKhalilov +40 more
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Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment [PDF]
ChannelsNeuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter.
Morgan Kok +3 more
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TGF-β2 Regulates Transcription of the K+/Cl− Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons [PDF]
Cells, 2022 KCC2 mediates extrusion of K+ and Cl− and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated.
Anastasia Rigkou +3 more
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Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
eLife, 2017 KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis
Vivek Mahadevan +12 more
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KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice [PDF]
Cell Reports, 2019 Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric +5 more
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The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice [PDF]
Data in Brief, 2016 K+–Cl− co-transporter (KCC2) and Na+–K+–2Cl− co-transporter (NKCC1) are the main regulators of neuronal intracellular chloride concentration; altered expression patterns of KCC2 and NKCC1 have been reported in several neurodegenerative diseases.
Takao Tsukahara +4 more
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Effect of protein synthesis inhibitors on the function of the neuronal K-Cl cotransporter KCC2 [PDF]
, 2010 The Cl- and HCO3- electrochemical gradients across the plasma membrane dictate the electrical consequences of GABAA receptor (GABAAR) function and thereby play a significant role in neuronal GABA-mediated signalling. In adult pyramidal neurons, responses
Martin Puskarjov
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Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library [PDF]
Frontiers in Molecular NeuroscienceIntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov +12 more
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