Results 91 to 100 of about 8,825 (235)

Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]

, 2004
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core   +1 more source

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

Epilepsia Open, Volume 10, Issue 6, Page 1762-1773, December 2025.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker, Marian Galovic, Elena Álvarez‐Barón, Adam Strzelczyk   +3 more
wiley   +1 more source

Interleukin-1 receptor type 1 is over-expressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant induced inflammatory pain [PDF]

, 2017
K
Antal, Miklós, Bakk, Erzsébet, Bardóczi, Zsuzsanna, Ducza, László, Dócs, Klaudia, Hegedűs, Krisztina, Hegyi, Zoltán, Holló, Krisztina, Kis, Gréta, Mészár, Zoltán Mihály, Papp, Ildikó   +10 more
core   +1 more source

Exploring the Cell Biological and Functional Effects of the First Disease Associated KCC1 Genetic Variant

Journal of Cellular Physiology, Volume 240, Issue 12, December 2025.
ABSTRACT The potassium chloride cotransporter 1 (KCC1) is ubiquitously expressed and essential for regulating cellular fluid balance. We identified a patient carrying a genetic variant (E1065K) in the KCC1 coding gene SLC12A4. This study explored the impact of the variant in ectopic cell systems and enhanced the understanding of cell biological ...
Meye Bloothooft, Jiahui Huang, Mira Hamze, Marien J. C. Houtman, Teun P. de Boer, Peter M. van Hasselt, Gerhard F. Ecker, Christophe Porcher, Igor Medina, Marcel A. G. van der Heyden   +9 more
wiley   +1 more source

Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons

Neural Plasticity, 2011
The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons.
Anastasia Ludwig, Pavel Uvarov, Christophe Pellegrino, Judith Thomas-Crusells, Sebastian Schuchmann, Mart Saarma, Matti S. Airaksinen, Claudio Rivera   +7 more
doaj   +1 more source

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function

Frontiers in Neurology, 2020
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu, Ru Liu, Ru Liu, Ru Liu, Junling Wang, Junling Wang, Junling Wang, Junling Wang, Shuli Liang, Guojun Zhang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +13 more
doaj   +1 more source

N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation [PDF]

Journal of Biological Chemistry, 2017
K+/Cl- cotransporter 2 (KCC2) is selectively expressed in the adult nervous system and allows neurons to maintain low intracellular Cl- levels. Thus, KCC2 activity is an essential prerequisite for fast hyperpolarizing synaptic inhibition mediated by type A γ-aminobutyric acid (GABAA) receptors, which are Cl--permeable, ligand-gated ion channels ...
Leslie C, Conway, Ross A, Cardarelli, Yvonne E, Moore, Karen, Jones, Lisa J, McWilliams, David J, Baker, Matthew P, Burnham, Roland W, Bürli, Qi, Wang, Nicholas J, Brandon, Stephen J, Moss, Tarek Z, Deeb   +11 more
openaire   +2 more sources

¬Immunolocalization of cation-chloride cotransporters in the developing and mature spinal cord of opossums, Monodelphis domestica

Frontiers in Neuroanatomy, 2013
Spinal inhibition is required to generate coordinated outputs between antagonistic muscles during locomotion. It relies on low neuronal chloride concentration set by two cation-chloride cotransporters, NKCC1 and KCC2 which, respectively, pumps Cl- in or ...
Ha-Loan ePhan, Jean-François ePflieger
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation

Frontiers in Cellular Neuroscience, 2019
Epilepsy is a common neurological disorder characterized by recurrent and unprovoked seizures thought to arise from impaired balance between neuronal excitation and inhibition.
Phan Q. Duy, Phan Q. Duy, Wyatt B. David, Kristopher T. Kahle, Kristopher T. Kahle, Kristopher T. Kahle, Kristopher T. Kahle, Kristopher T. Kahle   +7 more
doaj   +1 more source