Sexually dimorphic expression of KCC2 and GABA function [PDF]
Epilepsy Research, 2008 GABA(A) receptors have an age-adapted function in the brain. During early development, they mediate depolarizing effects, which result in activation of calcium-sensitive signaling processes that are important for the differentiation of the brain.
openaire +3 more sources
Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus
IBRO Neuroscience Reports, 2022 In adults, γ-aminobutyric acid (GABA) type A receptor (GABAAR)-mediated inhibition depends on the maintenance of low intracellular chloride anion concentration through neuron-specific potassium-chloride cotransporter-2 (KCC2).
Lulan Chen +12 more
doaj
GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase [PDF]
, 2017 This is the final version of the article. Available from the publisher via the DOI in this record.There is another ORE record for this publication: http://hdl.handle.net/10871/33406The K+-Cl-co-transporter KCC2 (SLC12A5) tunes the efficacy of ...
Al Awabdh, S +11 more
core +5 more sources
Involvement of the BDNF–TrkB–KCC2 pathway in neuropathic pain after brachial plexus avulsion
Brain and Behavior, 2022 Brachial plexus avulsion significantly increased brain‐derived neurotrophic factor (BDNF) release in the spinal cord. Here we investigated the involvement of the BDNF–TrkB–KCC2 pathway in neuropathic pain caused by BPA injury.
Shuo Zhao +8 more
semanticscholar +1 more source
Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo [PDF]
, 2006 Neurotransmission during development regulates synaptic maturation in neural circuits, but the contribution of different neurotransmitter systems is unclear.
Akerman, C. J., Cline, H. T.
core +1 more source
Differentiation Defect Into GABAergic Neurons in Cerebral Organoids From Autism Patients
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Summary of in vitro disease modeling and drug screening using ASD patient‐derived COs. This figure highlights the major phenotypes observed in COASD and the therapeutic effects of each compound screened in this study. ABSTRACT Objectives Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects social communication and behaviors ...
Sai Hali +20 more
wiley +1 more source
KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development [PDF]
Neuron, 2007 The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, independently of its Cl(-) transport function, is a key factor in the maturation of dendritic spines.
Kai Kaila +14 more
openaire +3 more sources
eLife, 2019 Up-regulation of the persistent sodium current (INaP) and down-regulation of the potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here identified calpain as the driver of the up- and down-regulation of INaP and KCC2,
Vanessa Plantier +6 more
doaj +1 more source
Neurochemical Research, 2022 Spasticity is a typical consequence after spinal cord injury (SCI). The critical reasons are reducing the synthesis of Gamma-Aminobutyric Acid (GABA), glycine and potassium chloride co-transporter 2 (KCC2) inside the distal spinal cord.
Xiangzhe Li +10 more
semanticscholar +1 more source
Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain [PDF]
, 2015 Peer ...
Jovanov-Milošević, Natasa +6 more
core +1 more source