Results 101 to 110 of about 9,762 (266)
Structural and functional roles of KCC2 in developing cortex [PDF]
, 2008 Cation chloride cotransporters (CCCs) are critical for controlling intracellular chloride homeostasis. The CCC family is composed of four isoforms of K-Cl cotransporters (KCC1-4), two isoforms of Na-K-2Cl cotransporters (NKCC1-2), one Na-Cl cotransporter
Li, Hong
core
BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus [PDF]
, 2015 Peer ...
Ahmad, Faraz +5 more
core +1 more source
Brain and Behavior, Volume 15, Issue 3, March 2025.The aim of the present study was to evaluate the anxiolytic and analgesic effects of the water extract of P. africanum on autistic triad induced in rats with sodium valproate. Pregnant female rats were given sodium valproate at 800 mg/kg during gestation.
Ambani Omgba Jeanne Julie +10 more
wiley +1 more source
Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability
Expert Opinion on Therapeutic Targets, 2020 Epilepsy is a common neurological disorder of neuronal hyperexcitability that begets recurrent and unprovoked seizures. The lack of a truly satisfactory pharmacotherapy for epilepsy highlights the clinical urgency for the discovery of new drug targets.
Phan Q. Duy +3 more
openaire +4 more sources
Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission
Scientific Reports, 2017 The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations ...
Anna Doshina +12 more
doaj +1 more source
Molecular Pain, 2022 GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K+-Cl--cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function.
Yuan Gao +9 more
semanticscholar +1 more source
Effect of protein synthesis inhibitors on the function of the neuronal K-Cl cotransporter KCC2 [PDF]
, 2010 The Cl- and HCO3- electrochemical gradients across the plasma membrane dictate the electrical consequences of GABAA receptor (GABAAR) function and thereby play a significant role in neuronal GABA-mediated signalling. In adult pyramidal neurons, responses
Puskarjov, Martin
core
CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.Acute poisoning with the organophosphate, soman, triggers status epilepticus that rapidly becomes refractory to standard of care treatment with midazolam (MDZ). Combined treatment with MDZ and allopregnanolone (ALLO) significantly suppresses seizure activity, which is associated with attenuated neurodegeneration and neuroinflammation.
Peter M. Andrew +10 more
wiley +1 more source
Transport-dependent and independent functions of KCC2 at excitatory synapses [PDF]
, 2020 This chapter explores non-canonical functions of the neuronal chloride/potassium KCC2 transporter at glutamatergic, excitatory synapses. The first section describes KCC2 expression and membrane dynamics in cortical neurons to show that KCC2 is enriched in dendritic spines that host excitatory synapses.
Chevy, Quentin +4 more
openaire +1 more source
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments [PDF]
, 2016 Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience.
Badura, A.M. (Aleksandra) +3 more
core +5 more sources