Results 101 to 110 of about 8,825 (235)

General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt [PDF]

, 2017
Background The developmental transition from depolarizing to hyperpolarizing γ-aminobutyric acid-mediated neurotransmission is primarily mediated by an increase in the amount of the potassium-chloride cotransporter KCC2 during early postnatal life ...
Bodogan, T., Fiumelli, H., Hemmings, H. C., Hemmings, H. C., Kaila, K., Lacoh, C.-M, Vutskits, L.   +6 more
core  

Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. [PDF]

, 2015
BACKGROUND: Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks.
Dobolyi, Arpád, Héja, László, Kardos, Julianna, Pál, Ildikó   +3 more
core   +1 more source

Characterization of optogenetically activated inhibitory inputs onto cholinergic motor neurons in the spinal dorsolateral nucleus

Physiological Reports, Volume 13, Issue 24, December 2025.
Abstract Inhibitory control of external urethral sphincter motor neurons (EUS‐MNs) in the spinal dorsolateral nucleus (DLN), which corresponds to a portion of Onuf's nucleus in humans, is essential for normal micturition by inducing EUS relaxation during voiding; yet synaptic mechanisms remain poorly characterized.
Tadanobu C. Kamijo, Sergei Karnup, Kanako Matsuoka, Shingo Kimura, Minoru Miyazato, Stephanie L. Daugherty, Jonathan M. Beckel, Naoki Yoshimura   +7 more
wiley   +1 more source

WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio).

PLoS Genetics, 2013
Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare pathology characterized by an early onset of severe sensory loss (all modalities) in the distal limbs.
Valérie Bercier, Edna Brustein, Meijiang Liao, Patrick A Dion, Ronald G Lafrenière, Guy A Rouleau, Pierre Drapeau   +6 more
doaj   +1 more source

Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum [PDF]

, 2012
Disruption of the potassium/chloride cotransporter 3 (KCC3), encoded by the SLC12A6 gene, causes hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC), a neurodevelopmental and neurodegenerative disorder ...
Dion, Patrick A., Gaudet, Rebecca, Hince, Pascale, Huot, Karine, Kurniawan, Nyoman, Laganiere, Janet, Mogil, Jeffrey S., Moldrich, Randal X., Rasheed, Sarah, Richards, Linda J., Ritchie, Jennifer, Rochefort, Daniel, Rouleau, Guy A., Salin-Cantegrel, Adele, Shekarabi, Masoud, Sotocinal, Susana G.   +15 more
core   +1 more source

Prenatal alcohol exposure perturbs the development of radial glial cells in the fetal olfactory bulb

Alcohol, Clinical and Experimental Research, Volume 49, Issue 11, Page 2494-2501, November 2025.
Prenatal alcohol exposure affects the development of radial glial cells (RGCs) in the embryonic mouse olfactory bulb. Ethanol administered at embryonic day 11, a time point when RGCs generate the largest number of mitral cells, caused G2/M arrest in RGCs, delaying their progression to mitosis and subsequent neuronal differentiation.
Yuka Imamura Kawasawa, Kazue Hashimoto‐Torii, Masaaki Torii, Fumiaki Imamura   +3 more
wiley   +1 more source

Traumatic Brain Injury Temporal Proteome Guides KCC2-Targeted Therapy

Journal of Neurotrauma, 2019
Advancing therapeutics for traumatic brain injury (TBI) remains a challenge, necessitating testable targets with interventions appropriately timed to intercede on evolving secondary insults. Neuroproteomics provides a global molecular approach to deduce the complex post-translational processes that underlie secondary events after TBI.
Pavel N, Lizhnyak, Pretal P, Muldoon, Pallavi P, Pilaka, John T, Povlishock, Andrew K, Ottens   +4 more
openaire   +3 more sources

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

Scientific Reports, 2017
The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations ...
Anna Doshina, Florian Gourgue, Michiho Onizuka, Remi Opsomer, Peng Wang, Kunie Ando, Bernadette Tasiaux, Ilse Dewachter, Pascal Kienlen-Campard, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot   +12 more
doaj   +1 more source

Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

Frontiers in Cellular Neuroscience, 2015
Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl- cotransporter (KCC2) in the CNS. Efficient KCC2 transport is essential for setting the neuronal Cl- gradient, which is required for fast GABAergic inhibition.
Vivek eMahadevan, Zahra eDargaei, Evgueni eIvakine, Anna-Maria eHartmann, David eNg, David eNg, Jonah eChevrier, John eOrmond, John eOrmond, Hans Gerd Nothwang, Roderick eMcInnes, Roderick eMcInnes, Melanie A Woodin   +12 more
doaj   +1 more source

Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]

, 2011
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo, Di Giovanni, Giuseppe, Errington, Adam C.   +2 more
core