Frontiers in Cellular Neuroscience, 2023 K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Abhishek Pethe +7 more
doaj +5 more sources
KCC2 downregulation facilitates epileptic seizures [PDF]
Scientific Reports, 2017 GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl−] concentration, which in adult depends on neuron specific K+-Cl− cotransporter-2 (KCC2).
Lulan Chen +6 more
doaj +3 more sources
Therapeutic potential for KCC2-targeted neurological diseases
Japanese Dental Science Review, 2023 Patients with neurological diseases, such as schizophrenia, tend to show low K+-Cl- co-transporter 2 (KCC2) levels in the brain. The cause of these diseases has been associated with stress and neuroinflammation.
Kazuo Tomita +11 more
doaj +3 more sources
KCC2 function modulates in vitro ictogenesis [PDF]
Neurobiology of Disease, 2015 GABAA receptor-mediated inhibition is active and may contribute to epileptiform synchronization. The efficacy of inhibition relies on low levels of intracellular Cl−, which are controlled by KCC2 activity.
Shabnam Hamidi, Massimo Avoli
doaj +3 more sources
Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures [PDF]
Frontiers in NeuroscienceIntroductionKetogenic diet (KD), a high-fat, low-carbohydrate, and adequate protein diet, is a non-pharmacological treatment for refractory epilepsy. However, their mechanism of action is not fully understood.
Leticia Granados-Rojas +10 more
doaj +2 more sources
M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation [PDF]
Frontiers in Molecular Neuroscience, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan +6 more
doaj +3 more sources
KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients [PDF]
Acta Neuropathologica Communications, 2019 Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression is suggested to play a key role in the neurodevelopmental delay in RTT patients’
Lisa Hinz +2 more
doaj +2 more sources
Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina [PDF]
, 2012 Regulation of ion and pH homeostasis is essential for normal neuronal function. The sodium-driven chloride bicarbonate exchanger NCBE (Slc4a10), a member of the SLC4 family of bicarbonate transporters, uses the transmembrane gradient of sodium to drive ...
Dedek, Karin +12 more
core +19 more sources
Enhancing KCC2 function counteracts morphine-induced hyperalgesia [PDF]
Scientific Reports, 2017 AbstractMorphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial dorsal horn (SDH) of the spinal cord, weakening spinal GABAA/glycine-mediated ...
Francesco Ferrini +4 more
openalex +5 more sources
Motion-Style Scalp Acupuncture Ameliorates Post-Stroke Muscle Spasticity Through Cerebral Blood Flow Augmentation and 5-HT<sub>2A</sub>R-Mediated Spinal KCC2 Reactivation. [PDF]
Brain BehavPathology of PSS and the antispastic mechanism of MSSA: A focus on cerebral blood flow augmentation and 5‐HT2AR‐mediated KCC2 activation. Abbreviations: CST, corticospinal tract; CRT, corticoreticular tract, RST, reticulospinal tract; rCBF, regional cerebral blood flow; PSS, post‐stroke spasticity. ABSTRACT Background Muscle spasticity, a prevalent and
Zhang QY +8 more
europepmc +2 more sources