Results 11 to 20 of about 9,762 (266)

Development of KCC2 therapeutics to treat neurological disorders [PDF]

Frontiers in Molecular Neuroscience
KCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS. Herein, we highlight KCC2 hypofunction as a fundamental and conserved pathology contributing to neuronal circuit excitation/inhibition (E/I) imbalances that underly ...
Shilpa D. Kadam, Shane V. Hegarty
doaj   +5 more sources

K+/Cl− cotransporter 2 (KCC2) and Na+/HCO3− cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation

Frontiers in Cellular Neuroscience, 2023
K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition. Electrogenic sodium bicarbonate cotransporter 1 (NBCe1) is a pH regulatory protein expressed in neurons and glial cells.
Abhishek Pethe, Mira Hamze, Marina Giannaki, Bernd Heimrich, Igor Medina, Anna-Maria Hartmann, Anna-Maria Hartmann, Eleni Roussa   +7 more
doaj   +6 more sources

Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons. [PDF]

Int J Mol Sci
The strength of inhibitory neurotransmission depends on intracellular neuronal chloride concentration, primarily regulated by the activity of cation-chloride cotransporters NKCC1 and KCC2.
Hamze M, Brier C, Buhler E, Zhang J, Medina I, Porcher C.   +5 more
europepmc   +4 more sources

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology [PDF]

Frontiers in Physiology, 2022
The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Degang Yang, Degang Yang, Degang Yang, Degang Yang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Liangjie Du, Liangjie Du, Liangjie Du, Liangjie Du, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li   +48 more
doaj   +3 more sources

Therapeutic potential for KCC2-targeted neurological diseases

Japanese Dental Science Review, 2023
Patients with neurological diseases, such as schizophrenia, tend to show low K+-Cl- co-transporter 2 (KCC2) levels in the brain. The cause of these diseases has been associated with stress and neuroinflammation. However, since the pathogenesis of these diseases is not yet fully investigated, drug therapy is still limited to symptomatic therapy ...
Kazuo Tomita, Yoshikazu Kuwahara, Kento Igarashi, Junichi Kitanaka, Nobue Kitanaka, Yuko Takashi, Koh-ichi Tanaka, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Akihiro Kurimasa, Yoshihiro Nishitani, Tomoaki Sato   +11 more
doaj   +5 more sources

Noise-induced hearing loss alters potassium-chloride cotransporter KCC2 and GABA inhibition in the auditory centers. [PDF]

Sci Rep
Homeostatic plasticity, the ability of neurons to maintain their averaged activity constant around a set point value, is thought to account for the central hyperactivity after hearing loss.
Parameshwarappa V, Siponen MI, Watabe I, Karkaba A, Galazyuk A, Noreña AJ.   +5 more
europepmc   +4 more sources

KCC2 downregulation after sciatic nerve injury enhances motor function recovery

Scientific Reports, 2023
Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl−] and depolarized GABAergic signaling.
Dennis Lawrence Cheung, Takuya Toda, Madoka Narushima, Kei Eto, Chitoshi Takayama, Tatsuko Ooba, Hiroaki Wake, Andrew John Moorhouse, Junichi Nabekura   +8 more
doaj   +2 more sources

NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons

Cells, 2023
Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous
Erwan Pol, Etienne Côme, Zaha Merlaud, Juliette Gouhier, Marion Russeau, Sophie Scotto-Lomassese, Imane Moutkine, Xavier Marques, Sabine Lévi   +8 more
doaj   +2 more sources

Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons

Frontiers in Cell and Developmental Biology, 2022
KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and ...
Francis J. Prael III, Francis J. Prael III, Kwangho Kim, Kwangho Kim, Yu Du, Brittany D. Spitznagel, Gary A. Sulikowski, Gary A. Sulikowski, Gary A. Sulikowski, Eric Delpire, C. David Weaver, C. David Weaver, C. David Weaver   +12 more
doaj   +2 more sources

Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission [PDF]

The Journal of Neuroscience, 2006
The neuron-specific K+–Cl−cotransporter KCC2 extrudes Cl−and renders GABA and glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-dependent KCC2 activation is regulated at the transcriptional level and by unknown posttranslational mechanisms.
Peter Blaesse, Eric Delpire, Isabelle Guillemin, Eckhard Friauf, Leonard Khiroug, Michaela Schweizer, Hans Gerd Nothwang, Jens Schindler   +7 more
openaire   +5 more sources