Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library [PDF]
Frontiers in Molecular NeuroscienceIntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov +12 more
doaj +2 more sources
VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons. [PDF]
Int J Mol SciThe potassium–chloride cotransporter KCC2 is the main extruder of Cl- in neurons. It plays a fundamental role in the activity of the inhibitory neurotransmitters (GABA and glycine) since low levels of KCC2 promote intracellular Cl- accumulation, leading ...
Capilla-López J +6 more
europepmc +2 more sources
Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons [PDF]
Neural Plasticity, 2011 The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons.
Anastasia Ludwig +7 more
doaj +2 more sources
Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala. [PDF]
Behav Brain FunctBackground Mood disorders, particularly depression and anxiety, are associated with zinc dyshomeostasis and aberrant GABAergic signaling. Activation of ZnR/GPR39 by synaptic zinc in the hippocampus triggers phosphorylation of extracellular regulated ...
Sagi R +7 more
europepmc +2 more sources
Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation
Frontiers in Molecular Neuroscience, 2023 The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed at higher levels than the Cl− transporter NKCC1 in mature compared to immature ...
Domenico Del Turco +8 more
doaj +2 more sources
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF [PDF]
Brain Structure and Function, 2023 The potassium chloride cotransporter 2 (KCC2) is the main Cl^− extruder in neurons. Any alteration in KCC2 levels leads to changes in Cl^− homeostasis and, consequently, in the polarity and amplitude of inhibitory synaptic potentials mediated by GABA or ...
Paula M. Calvo +3 more
openalex +2 more sources
Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
Frontiers in Molecular Neuroscience, 2022 K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory responses mediated by γ-aminobutyric acid (GABA) type A receptors.
Kirill Zavalin +5 more
doaj +2 more sources
Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity [PDF]
Frontiers in Cellular Neuroscience, 2019 The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift during development.
Etienne Côme +14 more
openaire +7 more sources
Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory
Frontiers in Molecular Neuroscience, 2023 The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of chloride into ...
Anna Kreis +10 more
doaj +2 more sources
iScience, 2022 Summary: Modulation of the neuronal K+/Cl− cotransporter 2 (KCC2) activity, which mediates Cl− export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an ...
Hila Asraf +5 more
doaj +3 more sources