Results 21 to 30 of about 8,825 (235)
Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons. [PDF]
Addict BiolDrug exposure alters VTA circuitry across drug classes. We show that acute morphine and cocaine, but not saline, disrupt chloride homeostasis in VTA GABA neurons, producing a depolarized GABAA reversal potential, impaired chloride extrusion, and posttranslational downregulation of KCC2. A glucocorticoid receptor antagonist did not prevent these effects;
Pearson AC +4 more
europepmc +2 more sources
KCC2 escape from neuropathic pain [PDF]
Science-Business eXchange, 2013 Researchers from Laval University have described an activator of the co-transporter KCC2 and shown its analgesic effect in mice. The group is developing next-generation compounds with better pharmacological properties.
Benjamin Boettner
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KCC2 membrane diffusion tunes neuronal chloride homeostasis [PDF]
Neuropharmacology, 2019 Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and ...
Etienne Côme +3 more
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Frontiers in Cell and Developmental Biology, 2022 KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and ...
Francis J. Prael III +12 more
doaj +1 more source
iScience, 2022 Summary: Modulation of the neuronal K+/Cl− cotransporter 2 (KCC2) activity, which mediates Cl− export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an ...
Hila Asraf +5 more
doaj +1 more source
Intracellular zinc inhibits KCC2 transporter activity [PDF]
Nature Neuroscience, 2009 We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons.
Michal, Hershfinkel +7 more
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The Multifaceted Roles of KCC2 in Cortical Development [PDF]
Trends in Neurosciences, 2021 KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe the molecular and cellular mechanisms involved in the multiple functions of KCC2 and its splice
Virtanen, Mari A. +4 more
openaire +4 more sources
Life, 2021 A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3–4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions are ...
Vitaliy E. Kalashnikov +6 more
doaj +1 more source
Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. [PDF]
, 2020 Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Brohawn, Stephen Graf +2 more
core +2 more sources
KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation [PDF]
The Journal of Neuroscience, 2015 Expression of the neuronal K/Cl transporter KCC2 is tightly regulated throughout development and by both normal and pathological neuronal activity. Changes in KCC2 expression have often been associated with altered chloride homeostasis and GABA signaling.
Quentin Chevy +8 more
openalex +4 more sources