Results 31 to 40 of about 4,475 (201)

KCC2 downregulation after sciatic nerve injury enhances motor function recovery

Scientific Reports, 2023
Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl−] and depolarized GABAergic signaling.
Dennis Lawrence Cheung, Takuya Toda, Madoka Narushima, Kei Eto, Chitoshi Takayama, Tatsuko Ooba, Hiroaki Wake, Andrew John Moorhouse, Junichi Nabekura   +8 more
doaj   +1 more source

Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition

eLife, 2017
KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis
Vivek Mahadevan, C Sahara Khademullah, Zahra Dargaei, Jonah Chevrier, Pavel Uvarov, Julian Kwan, Richard D Bagshaw, Tony Pawson, Andrew Emili, Yves De Koninck, Victor Anggono, Matti Airaksinen, Melanie A Woodin   +12 more
doaj   +1 more source

Intracellular zinc inhibits KCC2 transporter activity [PDF]

Nature Neuroscience, 2009
We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons.
Chen Abramovitch-Dahan, Michal Dagan-Rabin, Israel Sekler, Karl Kandler, Michal Hershfinkel, Elias Aizenman, Mandar A. Aras, Megan E. Knoch, Megan E. Knoch   +8 more
openaire   +2 more sources

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
doaj   +1 more source

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]

Epilepsy Research, 2008
During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Gregory C. Mathews, Nathan Polley, Eric Delpire, Lei Zhu   +3 more
openaire   +3 more sources

Effects of high vs moderate-intensity training on neuroplasticity and functional recovery after focal ischemia [PDF]

American Heart Association, 2017, 48 (10), pp.2855 - 2864, 2018
Background and Purpose: This study was designed to compare the effects of high-intensity interval training (HIT) and moderate-intensity continuous training (MOD) on functional recovery and cerebral plasticity during the first 2 weeks following cerebral ischemia. Methods: Rats were randomized as follows: Control (n=15), SHAM (n=9), MCAO (n=13), MCAO-D1 (
arxiv   +1 more source

Molecular architecture of potassium chloride co-transporter KCC2 [PDF]

Scientific Reports, 2017
AbstractKCC2 is a neuron specific K+-Cl− co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia. Despite significant accumulating data on the biology and electrophysiological properties of KCC2, structure-function relationships ...
Agez, Morgane, Schultz, Patrick, Medina, Igor, Baker, David, Burnham, Matthew, Cardarelli, Ross, Conway, Leslie, Garnier, Kelly, Geschwindner, Stefan, Gunnarsson, Anders, Mccall, Eileen, Frechard, Alexandre, Audebert, Stéphane, Deeb, Tarek, Moss, Stephen, Brandon, Nicholas, Wang, Qi, Dekker, Niek, Jawhari, Anass   +18 more
openaire   +6 more sources

Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

Frontiers in Cellular Neuroscience, 2011
The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus.
Ilgam eKhalilov, Ilgam eKhalilov, Ilgam eKhalilov, Geneviève eChazal, Geneviève eChazal, Geneviève eChazal, Ilona eChudotvorova, Ilona eChudotvorova, Ilona eChudotvorova, Christophe ePellegrino, Christophe ePellegrino, Christophe ePellegrino, Severine eCorby, Severine eCorby, Severine eCorby, Nadine eFerrand, Nadine eFerrand, Nadine eFerrand, Olena eGubkina, Olena eGubkina, Olena eGubkina, Romain eNardou, Romain eNardou, Romain eNardou, Roman eTyzio, Roman eTyzio, Roman eTyzio, Sumii eYamamoto, Sumii eYamamoto, Sumii eYamamoto, Thomas J Jentsch, Christian eHubner, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Igor eMedina, Igor eMedina, Igor eMedina   +40 more
doaj   +1 more source

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Frontiers in Molecular Neuroscience, 2019
GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of ...
Yvonne E. Moore, Leslie C. Conway, Heike J. Wobst, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss, Stephen J. Moss, Stephen J. Moss   +7 more
doaj   +1 more source

Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation–Chloride Cotransporters in Rat Cortical Neurons [PDF]

Int J Mol Sci
Mira Hamze, Cathy Brier, Emmanuelle Buhler, Jinwei Zhang, Igor Medina, Christophe Porcher   +5 more
openalex   +2 more sources