Results 31 to 40 of about 9,762 (266)

A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion. [PDF]

Front Mol Neurosci
The potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in neuronal development. In mature neurons, KCC2 maintains a low enough intracellular chloride concentration essential for inhibitory ...
Järvelä V, Hamze M, Komulainen-Ebrahim J, Rahikkala E, Piispala J, Kallio M, Kangas SM, Nickl T, Huttula M, Hinttala R, Uusimaa J, Medina I, Immonen EV.   +12 more
europepmc   +2 more sources

Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures [PDF]

Frontiers in Neuroscience
IntroductionKetogenic diet (KD), a high-fat, low-carbohydrate, and adequate protein diet, is a non-pharmacological treatment for refractory epilepsy. However, their mechanism of action is not fully understood.
Leticia Granados-Rojas, Leonardo Hernández-López, Emmanuel Leonardo Bahena-Alvarez, Tarsila Elizabeth Juárez-Zepeda, Verónica Custodio, Joyce Graciela Martínez-Galindo, Karina Jerónimo-Cruz, Miguel Tapia-Rodríguez, America Vanoye-Carlo, Pilar Duran, Carmen Rubio   +10 more
doaj   +2 more sources

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage [PDF]

Advanced Science, Volume 12, Issue 21, June 5, 2025.
New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang, Chang Xu, Yao‐Yao Ma, Wei‐Xuan Xue, Hao‐Yuan Wang, Lin‐Yao Fan, Chen‐Yu Zhang, Liang Li, Xiao‐Yang Zhang, Jing‐Ning Zhu, Qi‐Peng Zhang   +10 more
wiley   +2 more sources

Modulation of GABAergic System in a Chicken Retinal Ischemic Model: The Role of Chloride Cotransporters [PDF]

Journal of Neuroscience Research, Volume 103, Issue 5, May 2025.
Oxygen–glucose deprivation (OGD) promotes GABA release and increases NKCC1 levels, which change the electrochemical chloride gradient. In these circumstances, activation of ionotropic GABA receptors would lead to cell depolarization. Thus, in the early stages of ischemia, GABA intensifies glutamate excitotoxicity by an alteration in chloride ...
A. A. Nascimento, V. S. Miya‐Coreixas, D. S. M. Araújo, T. H. O. Nascimento, G. F. Santos, R. Brito, K. C. Calaza   +6 more
wiley   +2 more sources

Region and layer-specific expression of GABA_A receptor isoforms and KCC2 in developing cortex. [PDF]

Front Cell Neurosci
Introduction γ-Aminobutyric acid (GABA) type A receptors (GABAARs) are ligand-gated Cl-channels that mediate the bulk of inhibitory neurotransmission in the mature CNS and are targets of many drugs.
Zavalin K, Hassan A, Zhang Y, Khera Z, Lagrange AH.   +4 more
europepmc   +2 more sources

KCC2 escape from neuropathic pain [PDF]

Science-Business eXchange, 2013
Researchers from Laval University have described an activator of the co-transporter KCC2 and shown its analgesic effect in mice. The group is developing next-generation compounds with better pharmacological properties.
Benjamin Boettner
openaire   +3 more sources

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function [PDF]

Frontiers in Neurology, 2020
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl-) flow, which relies on the intracellular chloride concentration ([Cl-]i) of the postsynaptic neuron. The Na-K-2Cl cotransporter isoform 1 (NKCC1) and the K-Cl cotransporter
Ru Liu, Ru Liu, Ru Liu, Ru Liu, Junling Wang, Junling Wang, Junling Wang, Junling Wang, Shuli Liang, Guojun Zhang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +13 more
openaire   +5 more sources

Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development [PDF]

BMC Medicine, 2022
Neonatal sepsis can induce long-term cognitive impairment in adolescence or adulthood, but the underlying molecular mechanism is not fully understood.
Donghang Zhang, Yujiao Yang, Yaoxin Yang, Jin Liu, Tao Zhu, Han Huang, Cheng Zhou   +6 more
openalex   +2 more sources

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

PLoS ONE, 2020
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski, Michael Winklhofer, Anna-Maria Hartmann   +6 more
doaj   +3 more sources

The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice [PDF]

Data in Brief, 2016
K+–Cl− co-transporter (KCC2) and Na+–K+–2Cl− co-transporter (NKCC1) are the main regulators of neuronal intracellular chloride concentration; altered expression patterns of KCC2 and NKCC1 have been reported in several neurodegenerative diseases.
Tsukahara, Takao, Masuhara, Masaaki, Iwai, Haruki, Sonomura, Takahiro, Sato, Tomoaki   +4 more
core   +4 more sources