Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes
Cell Reports, 2019 Summary: The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling. This raises questions about whether neural processing is comparably altered. Here, we test whether the K+-Cl−
Josiane C.S. Mapplebeck +7 more
doaj +1 more source
Molecular architecture of potassium chloride co-transporter KCC2 [PDF]
Scientific Reports, 2017 AbstractKCC2 is a neuron specific K+-Cl− co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia. Despite significant accumulating data on the biology and electrophysiological properties of KCC2, structure-function relationships ...
Agez, Morgane +18 more
openaire +3 more sources
Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]
, 2009 During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan +48 more
core +2 more sources
Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function
Frontiers in Molecular Neuroscience, 2019 GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of ...
Yvonne E. Moore +7 more
doaj +1 more source
Global Properties of M31's Stellar Halo from the SPLASH Survey: III. Measuring the Stellar Velocity Dispersion Profile [PDF]
, 2017 We present the velocity dispersion of red giant branch (RGB) stars in M31's halo, derived by modeling the line of sight velocity distribution of over 5000 stars in 50 fields spread throughout M31's stellar halo.
Beaton, Rachael L. +9 more
core +3 more sources
Frontiers in Molecular Neuroscience, 2022 GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann +6 more
doaj +1 more source
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures [PDF]
, 2015 The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions.
A McKenna +35 more
core +2 more sources
Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity [PDF]
Frontiers in Cellular Neuroscience, 2019 The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift during development.
Etienne Côme +14 more
openaire +5 more sources
Diminished KCC2 confounds synapse specificity of LTP during senescence [PDF]
Nature Neuroscience, 2016 The synapse specificity of long-term potentiation (LTP) ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21-28 months) mice, LTP was relayed to unstimulated synapses, blemishing its synapse specificity.
Ferando, Isabella +2 more
openaire +2 more sources
KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels
Cell Reports, 2019 Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders.
Marie Goutierre +7 more
doaj +1 more source