Results 41 to 50 of about 4,475 (201)

Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

Frontiers in Molecular Neuroscience, 2023
The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed at higher levels than the Cl− transporter NKCC1 in mature compared to immature ...
Domenico Del Turco, Mandy H. Paul, Jessica Schlaudraff, Julia Muellerleile, Fran Bozic, Mario Vuksic, Peter Jedlicka, Peter Jedlicka, Thomas Deller   +8 more
doaj   +1 more source

Enhancing KCC2 function counteracts morphine-induced hyperalgesia [PDF]

Scientific Reports, 2017
AbstractMorphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial dorsal horn (SDH) of the spinal cord, weakening spinal GABAA/glycine-mediated ...
Francesco Ferrini, Louis-Etienne Lorenzo, Antoine G. Godin, Miorie Le Quang, Yves De Koninck   +4 more
openaire   +4 more sources

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

Frontiers in Molecular Neuroscience, 2020
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined.
Joshua L. Smalley, Georgina Kontou, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, David Albrecht, Krithika Abiraman, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Nicholas J. Brandon, Stephen J. Moss, Stephen J. Moss   +17 more
doaj   +1 more source

Noise-induced hearing loss alters potassium-chloride cotransporter KCC2 and GABA inhibition in the auditory centers [PDF]

Sci Rep
Vinay Parameshwarappa, M.I. Siponen, Isabelle Watabe, Alaa Karkaba, Alexander V. Galazyuk, Arnaud Noreña   +5 more
openalex   +2 more sources

WNK1/HSN2 isoform and the regulation of KCC2 activity [PDF]

Rare Diseases, 2013
Hereditary sensory and autonomic neuropathy type 2 is a rare autosomal recessive pathology presenting with early onset peripheral sensory defects. It arises from mutations affecting a specific isoform of the WNK1 kinase (with-no-lysine protein kinase 1) termed WNK1/HSN2. The role of WNK1 in the nervous system is not well understood. In our recent paper,
openaire   +3 more sources

Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments

Frontiers in Molecular Neuroscience, 2022
Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission
Michele Yeo, Qiaojuan Zhang, LeAnne Ding, Xiangjun Shen, Yong Chen, Wolfgang Liedtke   +5 more
doaj   +1 more source

KCC2 Much Chloride Might Not Be the Only Problem [PDF]

Epilepsy Currents, 2019
[Box: see text]
openaire   +3 more sources

M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation

Frontiers in Molecular Neuroscience, 2018
Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan, Liang Ren, Lulan Chen, Guoxiang Wang, Xu Liu, Benjamin H. Wang, Yun Wang   +6 more
doaj   +1 more source

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage

Advanced Science, EarlyView.
New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang, Chang Xu, Yao‐Yao Ma, Wei‐Xuan Xue, Hao‐Yuan Wang, Lin‐Yao Fan, Chen‐Yu Zhang, Liang Li, Xiao‐Yang Zhang, Jing‐Ning Zhu, Qi‐Peng Zhang   +10 more
wiley   +1 more source

Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential [PDF]

Channels, 2011
KCC2 comprises the major Cl(-) extruding mechanism in most adult neurons. Hyperpolarizing GABAergic transmission depends on KCC2 function. We recently demonstrated that glutamate reduces KCC2 function by a phosphorylation-dependent mechanism that leads to excitatory GABA responses. Here we investigated the methods by which to estimate changes in E(GABA)
Paul Davies, Henry H.C. Lee, Stephen J. Moss, Joshua Walker, Tarek Z. Deeb   +4 more
openaire   +3 more sources