Results 41 to 50 of about 9,762 (266)

Mechanistic insight into the initiation of spreading depolarizations: Is it really all about potassium? [PDF]

J Physiol
The Journal of Physiology, Volume 603, Issue 11, Page 3269-3273, 1 June 2025.
Rachel Ricks, Connie MacKenzie‐Gray Scott, Andrew J. Trevelyan, R. Ryley Parrish   +3 more
wiley   +2 more sources

Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions [PDF]

Frontiers in Molecular Neuroscience
During postnatal brain development, maintaining a delicate balance between excitation and inhibition (E/I) is essential for the precise formation of neuronal circuits.
Mohammad Naderi, Thi My Nhi Nguyen, Christopher Pompili, Raymond W. M. Kwong   +3 more
doaj   +2 more sources

SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons. [PDF]

iScience
Raveendran VA, Serranilla M, Asgarihafshejani A, de Saint-Rome M, Cherednychenko M, Mullany S, Mitchell JA, Pressey JC, Woodin MA.   +8 more
europepmc   +2 more sources

Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment

Acta Pharmacologica Sinica, 2023
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain, and GABA binding to the GABA_A receptor (GABA_AR) regulates Cl^- and ...
Erin McMoneagle, Jing Zhou, Shiyao Zhang, Weixue Huang, S. S. Josiah, Ke Ding, Yun Wang, Jinwei Zhang   +7 more
semanticscholar   +1 more source

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders

Molecules, 2023
Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale ...
P. Lam, Julia Newland, R. Faull, A. Kwakowsky   +3 more
semanticscholar   +1 more source

TGF-β2 Regulates Transcription of the K⁺/Cl⁻ Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons

Cells, 2022
KCC2 mediates extrusion of K+ and Cl− and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated.
Anastasia Rigkou, Attila Magyar, Jan Manuel Speer, Eleni Roussa   +3 more
doaj   +1 more source

The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2. [PDF]

Neurochem Int
Kok M, Hartnett-Scott K, Happe CL, MacDonald ML, Aizenman E, Brodsky JL.   +5 more
europepmc   +2 more sources

Prochlorperazine Withdraws the Delayed Onset Tonic Activity of Unloaded Rat Soleus Muscle: A Pilot Study

Life, 2021
A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3–4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions are ...
Vitaliy E. Kalashnikov, Sergey A. Tyganov, Olga V. Turtikova, Ekaterina P. Kalashnikova, Margarita V. Glazova, Timur M. Mirzoev, Boris S. Shenkman   +6 more
doaj   +1 more source

BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury

Molecular Pain, 2023
Mechanical allodynia can be evoked by punctate pressure contact with the skin (punctate mechanical allodynia) and dynamic contact stimulation induced by gentle touching of the skin (dynamic mechanical allodynia).
Zihan Hu, Xinren Yu, Pei Chen, Keyu Jin, Jing Zhou, Guoxiang Wang, Jiangning Yu, Tong Wu, Yulong Wang, F. Lin, Tingting Zhang, Yun Wang, Xuan Zhao   +12 more
semanticscholar   +1 more source

Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]

, 2009
During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan, Ben-Ari, Ben-Ari, Bettler, Bi, Blaesse, Carter, Cherubini, Davies, Delpire, Dutar, Fiumelli, Fujikawa, Galanopoulou, Ganguly, Gähwiler, Harrison, Hübner, Kahle, Kanaka, Kanaumi, Khazipov, Lambert, Leinekugel, Leinekugel, Leinekugel, Liu, Lu, Mynlieff, Newberry, Nuñez, Owens, Payne, Pfrieger, Plotkin, Rissman, Rivera, Scholz, Shen, Siebler, Stein, Takahashi, Thompson, Vicario-Abejón, Wang, Wu, Yan, Yu, Yuste   +48 more
core   +2 more sources