Results 51 to 60 of about 4,475 (201)
eLife, 2019 Up-regulation of the persistent sodium current (INaP) and down-regulation of the potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here identified calpain as the driver of the up- and down-regulation of INaP and KCC2,
Vanessa Plantier +6 more
doaj +1 more source
KCC2 is required for the survival of mature neurons but not for their development [PDF]
, 2020 ABSTRACTThe K+/Cl– co-transporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl−levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors GABAARs. In accordance with this, compromised KCC2 activity results in seizures but whether such deficits directly ...
Stephen J. Moss +11 more
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Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons [PDF]
Frontiers in Cellular Neuroscience, 2014 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregulation of the potassium chloride cotransporter 2 (KCC2)
Mòdol, Laura +4 more
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KCC2 membrane diffusion tunes neuronal chloride homeostasis [PDF]
Neuropharmacology, 2020 Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and ...
Sabine Lévi +4 more
openaire +3 more sources
Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus
IBRO Neuroscience Reports, 2022 In adults, γ-aminobutyric acid (GABA) type A receptor (GABAAR)-mediated inhibition depends on the maintenance of low intracellular chloride anion concentration through neuron-specific potassium-chloride cotransporter-2 (KCC2).
Lulan Chen +12 more
doaj
Frontiers in Cellular Neuroscience, 2015 Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic ...
Nancy D Merner +7 more
doaj +1 more source
Immunity and neuroinflammation in early stages of life and epilepsy
Epilepsia, EarlyView.Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García +5 more
wiley +1 more source
Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory
Frontiers in Molecular Neuroscience, 2023 The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of chloride into ...
Anna Kreis +10 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus +11 more
wiley +1 more source
KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development [PDF]
Neuron, 2007 The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, independently of its Cl(-) transport function, is a key factor in the maturation of dendritic spines.
Kai Kaila +14 more
openaire +3 more sources