Results 51 to 60 of about 8,825 (235)

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice

Neurobiology of Disease, 2020
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV.
Aaron J. Barbour, Kurt F. Hauser, A. Rory McQuiston, Pamela E. Knapp   +3 more
doaj   +1 more source

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination [PDF]

, 2016
Synaptic inhibition in the olfactory bulb (OB), the first relay station of olfactory information, is believed to be important for odour discrimination.
Carleton, Alan, Gschwend, Olivier, Gödde, Kathrin, Jentsch, Thomas J., Pfeffer, Carsten K., Puchkov, Dmytro   +5 more
core   +3 more sources

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

Frontiers in Molecular Neuroscience, 2020
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined.
Joshua L. Smalley, Georgina Kontou, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, David Albrecht, Krithika Abiraman, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Nicholas J. Brandon, Stephen J. Moss, Stephen J. Moss   +17 more
doaj   +1 more source

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

EBioMedicine, 2018
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic ...
Matt R. Kelley, Ross A. Cardarelli, Joshua L. Smalley, Thomas A. Ollerhead, Peter M. Andrew, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss   +7 more
doaj   +1 more source

BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia

Translational Neuroscience, 2015
Abstract Purpose: To investigate the effect of brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase (Trk) on potassium chloride cotransporter 2 (KCC2) in rats following nicotine withdrawal and the roles played by BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia.
Shi Wenhui, Ding Yonghong, Yu Ailan, Wang Qinghe, Zhang Zongwang, Zhang Li-Cai   +5 more
openaire   +3 more sources

Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo [PDF]

, 2006
Neurotransmission during development regulates synaptic maturation in neural circuits, but the contribution of different neurotransmitter systems is unclear.
Akerman, C. J., Cline, H. T.
core   +1 more source

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

PLoS ONE, 2020
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski, Michael Winklhofer, Anna-Maria Hartmann   +6 more
doaj   +1 more source

Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments

Frontiers in Molecular Neuroscience, 2022
Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission
Michele Yeo, Qiaojuan Zhang, LeAnne Ding, Xiangjun Shen, Yong Chen, Wolfgang Liedtke   +5 more
doaj   +1 more source

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]

Epilepsy Research, 2008
During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Lei, Zhu, Nathan, Polley, Gregory C, Mathews, Eric, Delpire   +3 more
openaire   +2 more sources

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

Frontiers in Cellular Neuroscience, 2015
Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic ...
Nancy D Merner, Madison R Chandler, Cynthia eBourassa, Bo eLiang, Arjun R Khanna, Patrick eDion, Guy eRouleau, Kristopher eKahle   +7 more
doaj   +1 more source