Results 51 to 60 of about 9,762 (266)
Cell Reports, 2014 KCC2 is the neuron-specific K+-Cl− cotransporter required for maintaining low intracellular Cl−, which is essential for fast inhibitory synaptic transmission in the mature CNS.
Vivek Mahadevan +12 more
doaj +1 more source
Intracellular zinc inhibits KCC2 transporter activity [PDF]
Nature Neuroscience, 2009 We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons.
Chen Abramovitch-Dahan +8 more
openaire +2 more sources
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
eLife, 2017 KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis
Vivek Mahadevan +12 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann +6 more
doaj +1 more source
Constitutive KCC2 Cell- and Synapse-Specifically Regulates NMDA Receptor Activity in the Spinal Cord
Journal of Neuroscience, 2023 K+-Cl− cotransporter-2 (KCC2) critically controls neuronal chloride homeostasis and maintains normal synaptic inhibition by GABA and glycine. Nerve injury diminishes synaptic inhibition in the spinal cord via KCC2 impairment.
Yuying Huang (黄玉莹) +5 more
semanticscholar +1 more source
Global Properties of M31's Stellar Halo from the SPLASH Survey: III. Measuring the Stellar Velocity Dispersion Profile [PDF]
, 2017 We present the velocity dispersion of red giant branch (RGB) stars in M31's halo, derived by modeling the line of sight velocity distribution of over 5000 stars in 50 fields spread throughout M31's stellar halo.
Beaton, Rachael L. +9 more
core +3 more sources
NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]
Epilepsy Research, 2008 During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Gregory C. Mathews +3 more
openaire +3 more sources
Effects of high vs moderate-intensity training on neuroplasticity and functional recovery after focal ischemia [PDF]
American Heart Association, 2017, 48 (10), pp.2855 - 2864, 2018 Background and Purpose: This study was designed to compare the effects of high-intensity interval training (HIT) and moderate-intensity continuous training (MOD) on functional recovery and cerebral plasticity during the first 2 weeks following cerebral ischemia. Methods: Rats were randomized as follows: Control (n=15), SHAM (n=9), MCAO (n=13), MCAO-D1 (
arxiv +1 more source
Serine 937 phosphorylation enhances KCC2 activity and strengthens synaptic inhibition
Scientific Reports, 2023 The potassium chloride cotransporter KCC2 is crucial for Cl^- extrusion from mature neurons and thus key to hyperpolarizing inhibition. Auditory brainstem circuits contain well-understood inhibitory projections and provide a potent model to study the ...
Tamara Radulovic +8 more
semanticscholar +1 more source
A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation [PDF]
, 2014 Genetic variation in SLC12A5 which encodes KCC2, the neuron‐specific cation‐chloride cotransporter that is essential for hyperpolarizing GABAergic signaling and formation of cortical dendritic spines, has not been reported in human disease.
Ahmad, Faraz +14 more
core +2 more sources