Results 61 to 70 of about 9,762 (266)

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

KCC2 Enhancers Normalize Reflex Responses and Improve Locomotor Function after Chronic Spinal Cord Injury

bioRxiv, 2023
Within a year after a spinal cord injury (SCI), 75% of individuals develop spasticity. While normal movement relies on the ability to adjust reflexes appropriately, and on reciprocal inhibition of antagonistic muscles, spastic individuals display ...
Jadwiga N. Bilchak, G. Caron, Simon M. Danner, Marie-Pascale Côté   +3 more
semanticscholar   +1 more source

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Frontiers in Molecular Neuroscience, 2019
GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of ...
Yvonne E. Moore, Leslie C. Conway, Heike J. Wobst, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss, Stephen J. Moss, Stephen J. Moss   +7 more
doaj   +1 more source

Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice

Journal of Neuroinflammation, 2023
The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic transmission plays a vital role in controlling learning, memory and synaptic plasticity.
Jing Rong, Yang Yang, Min Liang, Haiquan Zhong, Yingchun Li, Yichao Zhu, Sha Sha, Lei Chen, Rong Zhou   +8 more
semanticscholar   +1 more source

Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

Frontiers in Cellular Neuroscience, 2011
The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus.
Ilgam eKhalilov, Ilgam eKhalilov, Ilgam eKhalilov, Geneviève eChazal, Geneviève eChazal, Geneviève eChazal, Ilona eChudotvorova, Ilona eChudotvorova, Ilona eChudotvorova, Christophe ePellegrino, Christophe ePellegrino, Christophe ePellegrino, Severine eCorby, Severine eCorby, Severine eCorby, Nadine eFerrand, Nadine eFerrand, Nadine eFerrand, Olena eGubkina, Olena eGubkina, Olena eGubkina, Romain eNardou, Romain eNardou, Romain eNardou, Roman eTyzio, Roman eTyzio, Roman eTyzio, Sumii eYamamoto, Sumii eYamamoto, Sumii eYamamoto, Thomas J Jentsch, Christian eHubner, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Igor eMedina, Igor eMedina, Igor eMedina   +40 more
doaj   +1 more source

Sevoflurane-induced regulation of NKCC1/KCC2 phosphorylation through activation of Spak/OSR1 kinase and cognitive impairment in ischemia-reperfusion injury in rats. [PDF]

Heliyon
Wang Y, Zhang Y, Yu W, Dong M, Cheng P, Wang Y.   +5 more
europepmc   +3 more sources

A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2 [PDF]

, 2017
A plethora of neurological disorders are associated with alterations in the expression and localization of potassium-chloride cotransporter type 2 (KCC2), making KCC2 a critical player in neuronal function and an attractive target for therapeutic ...
Agez, Morgane, Friedel, Perrine, Jawhari, Anass, Ludwig, Anastasia, Medina, Igor, Pellegrino, Christophe, Rivera Baeza, Juan Claudio   +6 more
core   +2 more sources

A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells [PDF]

, 2017
Background: Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K-Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression in mammals.
Ludwig, Anastasia, Rivera Baeza, Claudio, Uvarov, Pavel   +2 more
core   +2 more sources

Enhancing KCC2 function counteracts morphine-induced hyperalgesia [PDF]

Scientific Reports, 2017
AbstractMorphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial dorsal horn (SDH) of the spinal cord, weakening spinal GABAA/glycine-mediated ...
Francesco Ferrini, Louis-Etienne Lorenzo, Antoine G. Godin, Miorie Le Quang, Yves De Koninck   +4 more
openaire   +4 more sources

KCC2 membrane diffusion tunes neuronal chloride homeostasis [PDF]

Neuropharmacology, 2020
Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and ...
Sabine Lévi, Sabine Lévi, Xavier Marques, Jean Christophe Poncer, Etienne Côme   +4 more
openaire   +4 more sources