Results 61 to 70 of about 4,475 (201)

Phytochemical, In Silico, In Vitro, and In Vivo Research on Piptadeniastrum africanum (Fabaceae) Unveiling Anti‐Stereotypic, Anxiolytic, and Analgesic Effects in a Sodium Valproate‐Induced Autistic Disorders Model

Brain and Behavior, Volume 15, Issue 3, March 2025.
The aim of the present study was to evaluate the anxiolytic and analgesic effects of the water extract of P. africanum on autistic triad induced in rats with sodium valproate. Pregnant female rats were given sodium valproate at 800 mg/kg during gestation.
Ambani Omgba Jeanne Julie, Ngouateu Omer Bébé, Mengue Ngadena Yolande Sandrine, Owona Pascal Emmanuel, Kandeda Kavaye Antoine, Ambamba Akamba Bruno Dupon, Nongni Piebeng Quentin Cicilien, Ngang Nguema Franck Emmanuel, Ngondi Judith Laure, Bilanda Danielle Claude, Dzeufiet Djomeni Paul Désiré   +10 more
wiley   +1 more source

BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia

Translational Neuroscience, 2015
Abstract Purpose: To investigate the effect of brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase (Trk) on potassium chloride cotransporter 2 (KCC2) in rats following nicotine withdrawal and the roles played by BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia.
Li-Cai Zhang, Yonghong Ding, Qinghe Wang, Zongwang Zhang, Ailan Yu, Wenhui Shi   +5 more
openaire   +4 more sources

Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman‐Induced Status Epilepticus in Male Rats

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
Acute poisoning with the organophosphate, soman, triggers status epilepticus that rapidly becomes refractory to standard of care treatment with midazolam (MDZ). Combined treatment with MDZ and allopregnanolone (ALLO) significantly suppresses seizure activity, which is associated with attenuated neurodegeneration and neuroinflammation.
Peter M. Andrew, Jeremy A. MacMahon, Xiuzhen Liu, Naomi H. Saito, Kyle E. Berger, Julia E. Morgan, Ashish Dhir, Danielle J. Harvey, Hilary S. McCarren, Michael A. Rogawski, Pamela J. Lein   +10 more
wiley   +1 more source

Mechanisms of comorbidity between Alzheimer's disease and pain

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
ABSTRACT Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive and speech impairments, AD patients, especially those in moderate to severe stages, are often overlooked in pain management.
Kaifang Yao, Shenjun Wang, Zhifang Xu, Zezhi Fan, Zhihan Chen, Peng Jia, Shiwei Tu, Yangyang Liu, Xiaowei Lin, Yuan Xu, Yuxing Fang, Baomin Dou, Yi Guo   +12 more
wiley   +1 more source

Sexually dimorphic expression of KCC2 and GABA function [PDF]

Epilepsy Research, 2008
GABA(A) receptors have an age-adapted function in the brain. During early development, they mediate depolarizing effects, which result in activation of calcium-sensitive signaling processes that are important for the differentiation of the brain.
openaire   +3 more sources

Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability

Expert Opinion on Therapeutic Targets, 2020
Epilepsy is a common neurological disorder of neuronal hyperexcitability that begets recurrent and unprovoked seizures. The lack of a truly satisfactory pharmacotherapy for epilepsy highlights the clinical urgency for the discovery of new drug targets.
Phan Q. Duy, Zhigang He, Kristopher T. Kahle, Miao He   +3 more
openaire   +4 more sources

Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology

Developmental Dynamics, Volume 254, Issue 2, Page 102-141, February 2025.
Abstract The ventral body wall (VBW) that encloses the thoracic and abdominal cavities arises by extensive cell movements and morphogenetic changes during embryonic development. These morphogenetic processes include embryonic folding generating the primary body wall; the initial ventral cover of the embryo, followed by directed mesodermal cell ...
Caroline Formstone, Bashar Aldeiri, Mark Davenport, Philippa Francis‐West   +3 more
wiley   +1 more source

Transport-dependent and independent functions of KCC2 at excitatory synapses [PDF]

, 2020
This chapter explores non-canonical functions of the neuronal chloride/potassium KCC2 transporter at glutamatergic, excitatory synapses. The first section describes KCC2 expression and membrane dynamics in cortical neurons to show that KCC2 is enriched in dendritic spines that host excitatory synapses.
Chevy, Quentin, Simonnet, Clémence, Al Awabdh, Sana, Lévi, Sabine, Poncer, Jean Christophe   +4 more
openaire   +2 more sources

Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes

Cell Reports, 2019
Summary: The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling. This raises questions about whether neural processing is comparably altered. Here, we test whether the K+-Cl−
Josiane C.S. Mapplebeck, Louis-Etienne Lorenzo, Kwan Yeop Lee, Cédric Gauthier, Milind M. Muley, Yves De Koninck, Steven A. Prescott, Michael W. Salter   +7 more
doaj  

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

Scientific Reports, 2017
The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations ...
Anna Doshina, Florian Gourgue, Michiho Onizuka, Remi Opsomer, Peng Wang, Kunie Ando, Bernadette Tasiaux, Ilse Dewachter, Pascal Kienlen-Campard, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot   +12 more
doaj   +1 more source