Results 71 to 80 of about 9,762 (266)

KCC2 Much Chloride Might Not Be the Only Problem [PDF]

Epilepsy Currents, 2019
[Box: see text]
openaire   +3 more sources

Molecular architecture of potassium chloride co-transporter KCC2 [PDF]

Scientific Reports, 2017
AbstractKCC2 is a neuron specific K+-Cl− co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia. Despite significant accumulating data on the biology and electrophysiological properties of KCC2, structure-function relationships ...
Agez, Morgane, Schultz, Patrick, Medina, Igor, Baker, David, Burnham, Matthew, Cardarelli, Ross, Conway, Leslie, Garnier, Kelly, Geschwindner, Stefan, Gunnarsson, Anders, Mccall, Eileen, Frechard, Alexandre, Audebert, Stéphane, Deeb, Tarek, Moss, Stephen, Brandon, Nicholas, Wang, Qi, Dekker, Niek, Jawhari, Anass   +18 more
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WNK1/HSN2 isoform and the regulation of KCC2 activity [PDF]

Rare Diseases, 2013
Hereditary sensory and autonomic neuropathy type 2 is a rare autosomal recessive pathology presenting with early onset peripheral sensory defects. It arises from mutations affecting a specific isoform of the WNK1 kinase (with-no-lysine protein kinase 1) termed WNK1/HSN2. The role of WNK1 in the nervous system is not well understood. In our recent paper,
openaire   +3 more sources

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures [PDF]

, 2015
The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions.
A McKenna, A McTague, AM Hartmann, AR Quinlan, C Rivera, CA Hübner, CA Hübner, DS Hekmat-Scafe, EF Pettersen, G Barcia, H Ashkenazy, H Fiumelli, H Li, I Chamma, I Chamma, J Söding, J Tornberg, K Wang, KJ Staley, KT Kahle, M Puskarjov, MA DePristo, MJ Sippl, MY Shen, N Eswar, NS Woo, P Blaesse, P Striano, PL Shaffer, RL Dunbrack Jr, S Vanhatalo, SK Chung, SP Antrobus, T Sakuma, W Hoch, Y Ben-Ari   +35 more
core   +2 more sources

Isoflurane-induced neuroinflammation and NKCC1/KCC2 dysregulation result in long-term cognitive disorder in neonatal mice

BMC Anesthesiology
Background The inhalational anesthetic isoflurane is commonly utilized in clinical practice, particularly in the field of pediatric anesthesia. Research has demonstrated its capacity to induce neuroinflammation and long-term behavioral disorders; however,
Dongni Xu, Jiayi Liu, Shiyu Meng, Meixian Sun, Yuqing Chen, Yu Hong   +5 more
semanticscholar   +1 more source

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

Communications Biology, 2021
NKCC and KCC transporters mediate coupled transport of Na + +K + +Cl − and K + +Cl − across the plasma membrane, thus regulating cell Cl − concentration and cell volume and playing critical roles in transepithelial salt and water transport and in ...
Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel, W. Zhuo, Suma Somasekharan, Kasturi Roy, Laixing Zhang, Yang Liu, Xianbin Meng, Haiteng Deng, Wenwen Zeng, Guohui Li, B. Forbush, Maojun Yang   +15 more
semanticscholar   +1 more source

Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential [PDF]

Channels, 2011
KCC2 comprises the major Cl(-) extruding mechanism in most adult neurons. Hyperpolarizing GABAergic transmission depends on KCC2 function. We recently demonstrated that glutamate reduces KCC2 function by a phosphorylation-dependent mechanism that leads to excitatory GABA responses. Here we investigated the methods by which to estimate changes in E(GABA)
Paul Davies, Henry H.C. Lee, Stephen J. Moss, Joshua Walker, Tarek Z. Deeb   +4 more
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Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

Frontiers in Cellular Neuroscience, 2015
Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic ...
Nancy D Merner, Madison R Chandler, Cynthia eBourassa, Bo eLiang, Arjun R Khanna, Patrick eDion, Guy eRouleau, Kristopher eKahle   +7 more
doaj   +1 more source

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

Frontiers in Molecular Neuroscience, 2020
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined.
Joshua L. Smalley, Georgina Kontou, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, David Albrecht, Krithika Abiraman, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Nicholas J. Brandon, Stephen J. Moss, Stephen J. Moss   +17 more
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A new mechanism of consciousness recovery from anesthesia regulated by K+‐Cl– cotransporter KCC2

Brain‐X, 2023
Neuroscience faces a puzzle in understanding the mechanism of general anesthesia. In the past, it was widely believed that recovery from anesthesia was a passive process caused by the breakdown of anesthetic agents.
Jinwei Zhang
semanticscholar   +1 more source