Results 71 to 80 of about 8,825 (235)

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. [PDF]

, 2017
Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism.
Amin, Hayder, Berdondini, Luca, De Pietri Tonelli, Davide, Marinaro, Federica   +3 more
core   +2 more sources

SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons

iScience
Inhibitory synaptic neurotransmission mediated by GABA requires a low concentration of chloride ions (Cl-) in neurons, which is established and maintained by the potassium-chloride co-transporter 2 (KCC2). While KCC2-interacting proteins are known to regulate KCC2 protein level and function, specific KCC2-interacting partners are still being identified
Vineeth A. Raveendran, Melissa Serranilla, Azam Asgarihafshejani, Miranda de Saint-Rome, Mariia Cherednychenko, Shanelle Mullany, Jennifer A. Mitchell, Jessica C. Pressey, Melanie A. Woodin   +8 more
openalex   +3 more sources

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

The Journal of Physiology, EarlyView.
Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus, Praveen Kumar, Kelly Kneale, T. Noah Hutson, Nicole M. Gautier‐Hall, Deng‐Shan Shiau, Megan Watts, Krystle Trosclair, Hemangini A. Dhaibar, Paari Dominic, Leonidas Iasemidis, Edward Glasscock   +11 more
wiley   +1 more source

Sexually dimorphic expression of KCC2 and GABA function [PDF]

Epilepsy Research, 2008
GABA(A) receptors have an age-adapted function in the brain. During early development, they mediate depolarizing effects, which result in activation of calcium-sensitive signaling processes that are important for the differentiation of the brain.
openaire   +2 more sources

Structural and functional roles of KCC2 in developing cortex [PDF]

, 2008
Cation chloride cotransporters (CCCs) are critical for controlling intracellular chloride homeostasis. The CCC family is composed of four isoforms of K-Cl cotransporters (KCC1-4), two isoforms of Na-K-2Cl cotransporters (NKCC1-2), one Na-Cl cotransporter
Li, Hong
core  

A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells [PDF]

, 2017
Background: Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K-Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression in mammals.
Ludwig, Anastasia, Rivera Baeza, Claudio, Uvarov, Pavel   +2 more
core   +2 more sources

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Impact of Anesthesia With Propofol on Epileptic Discharges Recorded by Stereo‐Electroencephalography in Pediatric Epilepsy Surgery

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
The number of spikes decreased under anesthesia, particularly within the SOZ, while HFOs increased under anesthesia. However, the extent of the increase did not differ between the SOZ and NSOZ. The number of HFOs appeared to be a more reliable interictal biomarker in ioEEG, particularly in the frontal cortex and cingulate cortex, and was not influenced
Chang Liu, Ping Ding, Tong Zhao, Tinghong Liu, Shijie Wu, Yuxiang Yan, Liu Yuan, Liwei Zhang, Shuli Liang   +8 more
wiley   +1 more source

Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth [PDF]

, 2017
During birth in mammals, a pronounced surge of fetal peripheral stress hormones takes place to promote survival in the transition to the extrauterine environment.
Crow, Ailey K., Deisseroth, Karl, Hsueh, Brian, Kaila, Kai, Lindfors, Jenna, Puskarjov, Martin, Ruusuvuori, Eva, Seja, Patricia, Spoljaric, Albert, Spoljaric, Inkeri, Summanen, Milla, Uvarov, Pavel, Virtanen, Mari A., Voipio, Juha   +13 more
core   +1 more source

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

Frontiers in Physiology, 2022
The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Degang Yang, Degang Yang, Degang Yang, Degang Yang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Liangjie Du, Liangjie Du, Liangjie Du, Liangjie Du, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li   +48 more
doaj   +1 more source