Results 81 to 90 of about 4,475 (201)

The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease

Alzheimer's &Dementia, Volume 20, Issue 10, Page 7369-7383, October 2024.
Abstract Neurogenesis persists throughout adulthood in the hippocampus and contributes to specific cognitive functions. In Alzheimer's disease (AD), the hippocampus is affected by pathology and functional impairment early in the disease. Human AD patients have reduced adult hippocampal neurogenesis (AHN) levels compared to age‐matched healthy controls.
Joris N. Geigenmüller, Atefe R. Tari, Ulrik Wisloff, Tara L. Walker   +3 more
wiley   +1 more source

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

Cell Reports, 2019
Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders.
Marie Goutierre, Sana Al Awabdh, Florian Donneger, Emeline François, Daniel Gomez-Dominguez, Theano Irinopoulou, Liset Menendez de la Prida, Jean Christophe Poncer   +7 more
doaj  

Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

Frontiers in Cellular Neuroscience, 2015
Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl- cotransporter (KCC2) in the CNS. Efficient KCC2 transport is essential for setting the neuronal Cl- gradient, which is required for fast GABAergic inhibition.
Vivek eMahadevan, Zahra eDargaei, Evgueni eIvakine, Anna-Maria eHartmann, David eNg, David eNg, Jonah eChevrier, John eOrmond, John eOrmond, Hans Gerd Nothwang, Roderick eMcInnes, Roderick eMcInnes, Melanie A Woodin   +12 more
doaj   +1 more source

Modulation of sleep/wake patterns by gephyrin phosphorylation status

European Journal of Neuroscience, Volume 60, Issue 7, Page 5431-5449, October 2024.
Gabra1 KO shows changes in NREM sleep in the dark phase, whereas the Gabra2 KO shows NREM sleep changes only in the parietal cortex where α2 subunit expression is high. Targeted proteomics analysis using tissue from sleep and sleep‐deprived cortical tissue shows sleep‐specific gephyrin interactome and gephyrin phosphorylation changes.
Yuan‐Chen Tsai, Waleed ElGrawani, Christine Muheim, Andrea Spinnler, Benjamin F. N. Campbell, Denis Lasic, Mohammad Hleihil, Steven A. Brown, Shiva K. Tyagarajan   +8 more
wiley   +1 more source

Advanced progress of vestibular compensation in vestibular neural networks

CNS Neuroscience &Therapeutics, Volume 30, Issue 9, September 2024.
The mechanism of vestibular compensation.11 The MVN receive afferent signals from the peripheral vestibular system and other brain regions, such as the cerebellum, the neuronal activity is balanced between the bilateral vestibular nuclei. After the unilateral peripheral injury, this loss of afferent leads to down‐regulation of neuronal activity in the ...
Jun Wang, Yuejin Zhang, Huajing Yang, E. Tian, Zhaoqi Guo, Jingyu Chen, Caijuan Qiao, Hongqun Jiang, Jiaqi Guo, Zhanghong Zhou, Qing Luo, Shiyu Shi, Hongyi Yao, Yisheng Lu, Sulin Zhang   +14 more
wiley   +1 more source

WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio).

PLoS Genetics, 2013
Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare pathology characterized by an early onset of severe sensory loss (all modalities) in the distal limbs.
Valérie Bercier, Edna Brustein, Meijiang Liao, Patrick A Dion, Ronald G Lafrenière, Guy A Rouleau, Pierre Drapeau   +6 more
doaj   +1 more source

KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Cell Reports, 2019
Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric, Albert Spoljaric, Martina Mavrovic, Patricia Seja, Martin Puskarjov, Kai Kaila   +5 more
doaj  

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

EBioMedicine, 2018
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic ...
Matt R. Kelley, Ross A. Cardarelli, Joshua L. Smalley, Thomas A. Ollerhead, Peter M. Andrew, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss   +7 more
doaj  

Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2

Frontiers in Cellular Neuroscience, 2014
In the mammalian central nervous system, the inhibitory strength of chloride (Cl-)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl- concentration ([Cl-]i).
Igor eMedina, Igor eMedina, Perrine eFriedel, Perrine eFriedel, Claudio eRivera, Claudio eRivera, Claudio eRivera, Kristopher T Kahle, Kristopher T Kahle, Nazim eKourdougli, Nazim eKourdougli, Pavel eUvarov, Christophe ePellegrino, Christophe ePellegrino   +13 more
doaj   +1 more source

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice

Neurobiology of Disease, 2020
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV.
Aaron J. Barbour, Kurt F. Hauser, A. Rory McQuiston, Pamela E. Knapp   +3 more
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