Results 81 to 90 of about 9,762 (266)
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination [PDF]
, 2016 Synaptic inhibition in the olfactory bulb (OB), the first relay station of olfactory information, is believed to be important for odour discrimination.
Carleton, Alan +5 more
core +3 more sources
Immunity and neuroinflammation in early stages of life and epilepsy
Epilepsia, EarlyView.Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García +5 more
wiley +1 more source
BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia
Translational Neuroscience, 2015 Abstract Purpose: To investigate the effect of brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase (Trk) on potassium chloride cotransporter 2 (KCC2) in rats following nicotine withdrawal and the roles played by BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia.
Li-Cai Zhang +5 more
openaire +4 more sources
KCC2 is required for the survival of mature neurons but not for their development [PDF]
, 2020 ABSTRACTThe K+/Cl– co-transporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl−levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors GABAARs. In accordance with this, compromised KCC2 activity results in seizures but whether such deficits directly ...
Stephen J. Moss +11 more
openaire +2 more sources
M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation
Frontiers in Molecular Neuroscience, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission
Michele Yeo +5 more
doaj +1 more source
Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders
, 2018 The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale.
Hines, Rochelle M. +2 more
core +2 more sources
Interaction of neuron-specific K+-Cl− cotransporter, KCC2, with brain-type creatine kinase [PDF]
, 2004 γ-Aminobutyric acid, a major inhibitory neurotransmitter within the adult central nervous system, is also known to be excitatory at early developmental stages due to the elevated intracellular Cl− concentration.
Fukuda, Atsuo +2 more
core +1 more source
Psychiatry and Clinical Neurosciences, EarlyView.Next‐generation sequencing has identified risk genes with large effect sizes for autism spectrum disorders (ASD). Although functional analysis of individual risk genes has progressed, the overall picture of ASD pathogenesis is unclear. Therefore, there is a need for morphological profiling of variants in these genes to fully comprehend their ...
Reza K. Arta +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus +11 more
wiley +1 more source