WNK Kinase Signaling in Ion Homeostasis and Human Disease [PDF]
, 2017 This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters
Delpire, Eric +5 more
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Food Frontiers, Volume 7, Issue 1, January 2026.This study investigates whether gestational probiotic and vitamin D supplementation can mitigate CPF effects in Wistar rats. While supplementation did not reverse CPF‐induced deficits, it induced notable neurodevelopmental changes in control animals, underscoring the need for further research on prenatal supplementation safety.
Mario Coca +8 more
wiley +1 more source
An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo [PDF]
, 2017 The neuron-specific K-Cl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in pyramidal neurons, and recent in vitro data suggest that this protein plays a role in the development of dendritic spines.
Belem, Bebyanda JT +8 more
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Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments [PDF]
, 2016 Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience.
Badura, A.M. (Aleksandra) +3 more
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American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone +13 more
wiley +1 more source
Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory
Frontiers in Molecular Neuroscience, 2023 The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of chloride into ...
Anna Kreis +10 more
doaj +1 more source
Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders
, 2018 The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale.
Hines, Rochelle M. +2 more
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Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing [PDF]
, 2016 In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition.
Beggs, S +7 more
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Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions
CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.Carbogen, a low‐dose CO2/O2 mixture, modulates brain pH to suppress hyperexcitability through rapid and reversible pH‐dependent mechanisms distinct from conventional antiseizure medications (ASMs). Preclinical and small clinical studies show efficacy in focal and absence seizures, whereas variable responses in other types highlight the need for ...
Li Wang +5 more
wiley +1 more source
Generation and Characterization of the Cation-Chloride Cotransporter KCC2 Hypomorphic Mouse [PDF]
, 2006 The cation-Cl- cotransporter (CCC) family comprises of Na+-Cl- cotransporter (NCC), Na+-K+-2Cl- cotransporters (NKCC1-2), and four K+-Cl- cotransporters (KCC1-4).
Tornberg, Janne
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