Results 121 to 130 of about 56,140 (348)

GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation

Theranostics
Background and Purpose: Vascular aging is a prior marker of human aging and a significant contributor to atherosclerosis and vascular calcification. However, there are limited pharmacological options available to mitigate vascular aging. Thus, understanding the mechanisms underlying vascular aging and age-related atherosclerosis and vascular ...
Cheng, Yanfei, Zheng, Guobin, Huang, Heming, Ni, Jingyu, Zhao, Yun, Sun, Yuting, Chang, Yingxin, Liu, Shangjing, He, Feng, Li, Dan, Guo, Yuying, Miao, Yaodong, Xu, Mengxin, Wang, Dongyue, Zhang, Yunsha, Hua, Yunqing, Yang, Shu, Fan, Guanwei, Ma, Chuanrui   +18 more
openaire   +2 more sources

Alginate Oligosaccharides Attenuate Ochratoxin A‐Induced Liver Injury through Regulating the Interaction of Nrf2 and NF‐κB Signaling Pathways

Food Frontiers, EarlyView.
A schematic illustration for the protective effects of AOS on OTA‐induced liver injury in mice. AOS, alginate oligosaccharides; CAT, catalase; GSTT1, glutathione S‐transferase theta 1; HO‐1, heme oxygenase 1; IκBα, inhibitor kappa B alpha; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; Keap1, kelch‐like ech‐associated protein 1; NF‐κB, nuclear factor ...
Yue Zhao, Xueqing Ye, Yan Guo, Zhongxiang Zhao, Qinghua Yao, Yaoyao Wang, Huimei Liu, Ziwei Lin, Wenchao Liu   +8 more
wiley   +1 more source

The Carbon Number‐specific Impact of Mineral Oil Saturated Hydrocarbons on Inducing Colonic Inflammation in Female and Male Fischer 344 Rats

Food Frontiers, EarlyView.
MOSH‐induced colonic alterations and sex‐specific metabolic pathways in female and male F344 rats. ABSTRACT This study investigated the effects of mineral oil saturated hydrocarbon (MOSH) sub‐fractions (C20‐30 and C30‐50) on the colon of male and female F344 rats and the underlying mechanisms.
Lin Zhu, Mingming Zhang, Hong Zhang, Hai Zhang, Boyan Gao, Liangli (Lucy) Yu, Yaqiong Zhang   +6 more
wiley   +1 more source

KEAP1-mutant atypical meningioma: illustrative case

Journal of Neurosurgery: Case Lessons
BACKGROUND While genetic testing of tumors is commonly used to inform the selection of systemic therapies, there is limited evidence for the application of radiotherapy for brain cancer. Recent studies have shown that Kelch-like ECH-associated protein 1 (KEAP1), a key regulator of cellular
Harary, Paul M, Hori, Yusuke S, Persad, Amit R. L, Tayag, Armine, Ustrzynski, Louisa, Emrich, Sara C, Rahimy, Elham, Park, David J, Li, Gordon, Chang, Steven D   +9 more
openaire   +2 more sources

Characterization of the Antioxidant Peptides Prepared From the Seed Kernel of Xanthoceras sorbifolium Using Enzymatic Hydrolysis: Molecular Docking Analysis and In Vitro Binding Studies

Food Safety and Health, EarlyView.
XSPH‐I exhibits excellent cellular antioxidant activity and cell protective effects. Four novel antioxidant peptides were screened from XSPH‐I peptide, and the newly synthetic peptide exhibits excellent antioxidant properties in vitro. ABSTRACT In this study, the antioxidant peptides (XSPH) from Xanthoceras sorbifolium oleifera were extracted and ...
Yalin Li, Chao Liu, Rong Sun, Jinyue Sun, Ye Shi, Shihai Lu, Dahu Zhang, Jinwei Qi, Xu Guo, Zhenlin Han, Ningyang Li   +10 more
wiley   +1 more source

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants [PDF]

, 2017
The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-RING E3 ubiquitin ligase (CRL) multisubunit protein complex.
Canning, Peter, Dinkova-Kostova, Albena T., Kostov, Rumen V.   +2 more
core   +3 more sources

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways.

PLoS ONE, 2020
Kahweol is a diterpene found in coffee beans and unfiltered coffee drinks. Several studies have demonstrated that kahweol induces the nuclear factor erythroid-2 related factor 2/ hemeoxygenase-1 (Nrf2/HO-1) pathway; however, the mechanisms involved are ...
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang   +5 more
doaj   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives [PDF]

, 2016
The Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response elements pathway enables cells to survive oxidative stress conditions through regulating the expression of cytoprotective enzymes such
Alsaid, Mansour S, Arafa, Reem K, Dinkova-Kostova, Albena T, Elghazawy, Nehal H, Ghorab, Mostafa M, Higgins, Maureen, Shahat, Abdelaaty A   +6 more
core   +3 more sources

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source