Results 1 to 10 of about 21,045 (211)

Association of Three SNPs Loci of Kelch-Like-ECH-Associated Protein 1 (Human) with Tuberculosis in Chinese Han Population [PDF]

International Journal of General Medicine, 2022
Shouquan Wu,* Xiaojuan Ding,* Qianlan Yang, Minggui Wang, Jian-Qing He Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China*These authors contributed equally to ...
Wu S, Ding X, Yang Q, Wang M, He JQ
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Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells [PDF]

Frontiers in Pharmacology, 2020
The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with mitochondrial toxicity and accumulation
Noëmi Johanna Roos, Noëmi Johanna Roos, Noëmi Johanna Roos, Diell Aliu, Diell Aliu, Jamal Bouitbir, Jamal Bouitbir, Jamal Bouitbir, Stephan Krähenbühl, Stephan Krähenbühl, Stephan Krähenbühl   +10 more
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Virtual Screening of Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and In Vitro Validation [PDF]

Molecules
The transcription factor erythroid 2-related factor 2 (Nrf2) is a central regulator of cellular defense mechanisms against oxidative stress and inflammation.
Zhengwan Huang, Zhengang Peng, Dandan Huang, Zhongyu Zhou   +3 more
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Keap1/Nrf2 Signaling Pathway [PDF]

Antioxidants, 2021
Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of ...
Gerasimos P. Sykiotis
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Analogs of imine resveratrol alleviate oxidative stress‐induced neurotoxicity in PC12 cells via activation of Nrf2

FEBS Open Bio, 2021
Oxidative stress is closely associated with neurodegenerative, cardiovascular and metabolic diseases. Resveratrol and related compounds have shown great potential as antioxidants via either direct scavenging of abundant reactive oxygen species (ROS) or ...
Yin Zhang, Zhixiong Wang, Jiehong Yang, Yu He, Haitong Wan, Chang Li   +5 more
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Demethylcalabaxanthone from Garcinia mangostana Exerts Antioxidant Effects through the Activation of the Nrf2 Pathway as Assessed via Molecular Docking and Biological Evaluation

Antioxidants, 2023
Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway activation promotes the expression of antioxidant enzymes in response to rising oxidative stress, resulting in reactive oxygen species (ROS) detoxification and playing a central role in the ...
Simona De Vita, Milena Masullo, Sabrina Grambone, Paloma Bermejo Bescós, Sonia Piacente, Giuseppe Bifulco   +5 more
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LBP reduces theinflammatory injuryof kidney in septic rat and regulates the Keap1-Nrf2∕ARE signaling pathway [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose: To investigate the influence of lycium barbarum polysaccharides (LBP), a functional derivative from lycium barbarum, on septic kidney injury. Methods: The SD male rats were randomly divided into 8 groups. The concentration of IL-1β, IL-6, IL-8,
Yayi Huang, Fang Zhou, Chen Shen, Huaxin Wang, Yeda Xiao   +4 more
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Lung adenocarcinoma patients with KEAP1 mutation harboring low immune cell infiltration and low activity of immune environment

Thoracic Cancer, 2021
Background Kelch‐like ECH‐associated protein 1 (KEAP1) has been identified as a cancer driver gene in lung adenocarcinoma (LUAD), and increased evidence has given us clues about the association of KEAP1 mutation and immune characteristics.
Wanwan Cheng, Bin Xu, Haitao Zhang, Shencun Fang   +3 more
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Flesh Shear Force, Cooking Loss, Muscle Antioxidant Status and Relative Expression of Signaling Molecules (Nrf2, Keap1, TOR, and CK2) and Their Target Genes in Young Grass Carp (Ctenopharyngodon idella) Muscle Fed with Graded Levels of Choline. [PDF]

PLoS ONE, 2015
Six groups of grass carp (average weight 266.9 ± 0.6 g) were fed diets containing 197, 385, 770, 1082, 1436 and 1795 mg choline/kg, for 8 weeks. Fish growth, and muscle nutrient (protein, fat and amino acid) content of young grass carp were significantly
Hua-Fu Zhao, Lin Feng, Wei-Dan Jiang, Yang Liu, Jun Jiang, Pei Wu, Juan Zhao, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou   +11 more
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The Protective Role of Nrf2 in Renal Tubular Cells in Oxidised Low-Density Lipoprotein-Induced Fibrosis

Analytical Cellular Pathology, 2023
Background: CD36 is the receptor of oxidised low-density lipoprotein (OxLDL) in renal tubular epithelial cells. Nuclear factor erythroid 2-related factor 2 (Nrf2) is the key factor in the activation of the Nrf2 signalling pathway and the regulation of ...
Xiangju Long, Zhe Liu, Yanan Sun, Hong Zhang   +3 more
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