Results 41 to 50 of about 21,045 (211)

Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators

ChemistryOpen, 2022
This is the first study investigating the nuclear factor (erythroid‐derived 2)‐like 2 (NRF2) activity of compounds containing a new scaffold, tetrahydrobenzo[b]thiophene.
Kit‐Kay Mak, Zhang Shiming, Dr. Ola Epemolu, Prof. Dr. Albena T. Dinkova‐Kostova, Dr. Geoffrey Wells, Dr. Irina G. Gazaryan, Dr. Raghavendra Sakirolla, Prof. Dr. Zulkefeli Mohd, Prof. Dr. Mallikarjuna Rao Pichika   +8 more
doaj   +1 more source

The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

Antioxidants, 2020
Background: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis.
Dionysios V. Chartoumpekis, Panos G. Ziros, Ilias Georgakopoulos-Soares, Adam A. T. Smith, Ana Claudia Marques, Mark Ibberson, Peter A. Kopp, Ioannis Habeos, Ioannis P. Trougakos, Nicholas K. H. Khoo, Gerasimos P. Sykiotis   +10 more
doaj   +1 more source

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

Antioxidants, 2022
Cells that experience high levels of oxidative stress respond by inducing antioxidant proteins through activation of the protein transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2).
Vy Ngo, Nadun C. Karunatilleke, Anne Brickenden, Wing-Yiu Choy, Martin L. Duennwald   +4 more
doaj   +1 more source

Binding of dipeptidyl peptidase III to the oxidative stress cell sensor Kelch-like ECH-associated protein 1 is a two-step process

Journal of Biomolecular Structure and Dynamics, 2020
This work is about synergy of theory and experiment in revealing mechanism of binding of dipeptidyl peptidase III (DPP III) and Kelch-like ECH-associated protein 1 (KEAP1), the main cellular sensor of oxidative stress. The NRF2 ̶ KEAP1 signaling pathway is important for cell protection, but it is also impaired in many cancer cells where NRF2 target ...
Sara Matić, Ivana Kekez, Marko Tomin, Ferenc Bogár, Filip Šupljika, Saša Kazazić, Maja Hanić, Shalinee Jha, Hrvoje Brkić, Benjamin Bourgeois, Tobias Madl, Karl Gruber, Peter Macheroux, Dubravka Matković-Čalogović, Mihaela Matovina, Sanja Tomić   +15 more
openaire   +3 more sources

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants [PDF]

, 2017
The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-RING E3 ubiquitin ligase (CRL) multisubunit protein complex.
Canning, Peter, Dinkova-Kostova, Albena T., Kostov, Rumen V.   +2 more
core   +3 more sources

Auranofin, a Gold(I)-Containing Antirheumatic Compound, Activates Keap1/Nrf2 Signaling via Rac1/iNOS Signal and Mitogen-Activated Protein Kinase Activation

Journal of Pharmacological Sciences, 2010
Auranofin (2,3,4,6-tetra-O-acetyl-1-thio-β-d-glucopyranosato-S-[triethylphosphine] gold) is a gold(I)-containing antirheumatic drug that possesses anti-inflammatory properties.
Nam-Hoon Kim, Mi-Kyung Oh, Hyo Jung Park, In-Sook Kim   +3 more
doaj   +1 more source

Design, synthesis and evaluation of novel small molecules acting as Keap1-Nrf2 protein-protein interaction inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Direct interference with Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 protein-protein interaction (PPI) has recently been introduced as an attractive approach to control life-threatening diseases like myocarditis.
Yunfeng Sun, Lulu Zheng, Bo Yang, Shuyu Ge, Qiang Li, Mingwan Zhang, Shenghui Shen, Yin Ying   +7 more
doaj   +1 more source

Keap1 Expression for Predicting the Chemoresistance and Prognosis of Advanced 
Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2012
Background and objective It has been proven that Kelch-like ECH-associated protein 1 (Keap1) expression was correlated with the chemoresistance of platinum drugs. The aim of this study is to investigate the protein expression levels of Keap1 in non-small
Baoshan CAO, Xiang ZHU, Sen CHEN, Yu XIAO, Li LIANG   +4 more
doaj   +1 more source

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies [PDF]

, 2019
A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the
Meierhofer, David, Xiao, Yi
core   +2 more sources

The Preventive Mechanism of Anserine on Tert-Butyl Hydroperoxide-Induced Liver Injury in L-02 Cells via Regulating the Keap1-Nrf2 and JNK-Caspase-3 Signaling Pathways

Marine Drugs, 2023
Anserine is a naturally occurring histidine dipeptide with significant antioxidant activities. This study aimed to investigate the preventive mechanism of anserine on tert-butyl hydroperoxide (TBHP)-induced liver damage in a normal human liver cell line (
Ming Chen, Jing Luo, Hongwu Ji, Wenkui Song, Di Zhang, Weiming Su, Shucheng Liu   +6 more
doaj   +1 more source