Results 61 to 70 of about 21,045 (211)

Nrf2 Mediates Metabolic Reprogramming in Non-Small Cell Lung Cancer

Frontiers in Oncology, 2020
Nuclear factor erythroid-2–related factor-2 (NFE2L2/Nrf2) is a transcription factor that regulates the expression of antioxidant genes. Both Kelch-like ECH-associated protein 1 (Keap1) mutations and Nrf2 mutations contribute to the activation of Nrf2 in ...
Jiangang Zhao, Xu Lin, Di Meng, Liping Zeng, Runzhou Zhuang, Sha Huang, Wang Lv, Jian Hu   +7 more
doaj   +1 more source

Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia

Molecular & Cellular Oncology, 2018
The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor E2-related factor 2 (NRF2L2, best known as NRF2) pathway plays a pivotal cytoprotective role in the regulation of cellular responses to oxidative stress.
Kristian M Bowles, Stuart A Rushworth
doaj   +1 more source

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A [PDF]

, 2018
Chaperone-mediated autophagy (CMA) is a selective degradative process for cytosolic proteins that contributes to the maintenance of proteostasis. The signaling mechanisms that control CMA are not fully understood but might involve response to stress ...
Arias, Esperanza, Cuadrado, Antonio, Cuervo, Ana María, Díaz-Carretero, Antonio, Pajares, Marta, Rojo, Ana I.   +5 more
core   +3 more sources

1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity

Journal of Lipid Research
Obesity leads to numerous illnesses and metabolic disorders, with lysophosphatidylcholine levels declining in obese patients. However, the physiological role of lysophosphatidylcholine and the regulatory mechanisms involved in modulating obesity remain ...
Rui Wang, Tianfu Zhu, Jingxian Lu, Mengke Cheng, Xingyun Wang, Xirong Guo, Shan Huang, Jianfang Gao   +7 more
doaj   +1 more source

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy [PDF]

, 2017
Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis.
A Jain, A Morelli, A Moustapha, AE Dikalova, AK Prasad, AP Joselin, B Bekdeser, B Bingol, B Mishra, C Hu, C Jo, D Faccenda, D Marcotte, D Narendra, DA East, DP Narendra, F Strappazzon, G Ashrafi, H Katayama, HC Bertrand, I Kim, J Gatliff, J Gatliff, J Lee, J Li, J Yan, J-A Pan, J-Y Lee, JD Clarke, JD Hayes, K Palikaras, KL Cheung, L Baird, L Mastrangelo, LC Gomes, M Frank, M Lazarou, MV Tsiper, N Wakabayashi, ND Georgakopoulos, Q Jiang, RC Scaduto, RLA Vries de, S Holm, S Kovac, S Li, S Melser, SE Dickinson, T Saito, X Xie, Y Ichimura, Y Katsuragi, Y Wang, Z-Y Jiang   +53 more
core   +3 more sources

Ultraviolet A Irradiation Induces NF-E2-Related Factor 2 Activation in Dermal Fibroblasts: Protective Role in UVA-Induced Apoptosis [PDF]

, 2005
Ultraviolet (UV) radiation is one of the most important environmental factors involved in the pathogenesis of skin aging and cancer. Many harmful effects of UV radiation are associated with the generation of reactive oxygen species, and cellular ...
Banno Tomohiro, Hirota Ayako, Itoh Ken, Kawachi Yasuhiro, Nakamura Yasuhiro, Otsuka Fujio, Takahashi Takenori, Xu Xuezhu, Yamamoto Masayuki, 川内 康弘   +9 more
core   +1 more source

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

The role of small RNAs in Paget's associated osteosarcoma [PDF]

, 2018
Small RNAs (sRNAs) are a class of non-coding RNA molecules that arekey regulators of gene expression. SRNAs are also specific biomarkersdue to their dysregulation in disease.
Green, Darrell, Dalmay, Tamas, Fraser, William   +2 more
core   +2 more sources

Galacto-Oligosaccharide Alleviates Alcohol-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation

Metabolites, 2022
Alcoholic liver disease (ALD) is a primary cause of mortality and morbidity worldwide. Oxidative stress and inflammation are important pathogenic factors contributing to ALD.
Shipeng Zhou, Qiuhua Tan, Bingjian Wen, Yan Bai, Qishi Che, Hua Cao, Jiao Guo, Zhengquan Su   +7 more
doaj   +1 more source

FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. [PDF]

, 2019
BackgroundThe transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance ...
Cheng, Jing-Yan, Cheng, Kai-Chun, Hsu, Huan-Ming, Liang, Yuh-Jin, Lin, Ruey-Jen, Wang, Sheng-Hung, Wu, Jen-Chine, Yu, Alice L, Yu, John, Yu, Jyh-Cherng   +9 more
core   +1 more source