Results 51 to 60 of about 21,045 (211)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner [PDF]

, 2021
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response ...
Ahn, Clarke, Cornblatt, Dibble, Dinkova-Kostova, Fang, Ferreira de Oliveira, Hawley, Iaconelli, Jeong, Kim, Kumar, Matsui, Matsui, Morales, Moreno-Gonzalo, Myzak, Nave, Nishioka, Rozengurt, Sawai, Saxton, Shawky, Shen, Torrente, Wiczk, Wu, Yang, Zhang, Zhang, Zhang, Zhang, Zhang   +32 more
core   +3 more sources

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

Cell Reports, 2014
Kelch-like ECH-associated protein 1 (Keap1) is a ubiquitin E3 ligase specificity factor that targets transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) for ubiquitination and degradation.
Megan R. Edwards, Britney Johnson, Chad E. Mire, Wei Xu, Reed S. Shabman, Lauren N. Speller, Daisy W. Leung, Thomas W. Geisbert, Gaya K. Amarasinghe, Christopher F. Basler   +9 more
doaj   +1 more source

Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis [PDF]

, 2016
Systemic biomarkers of oxidative stress can be relevant for assessment of psoriasis severity, for prediction of the outcome of therapy and of the development of comorbidities.
Cavaliere, Arturo, Palmery, Maura, Peluso, Ilaria   +2 more
core   +2 more sources

USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice

Nature Communications, 2023
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor responsible for mounting an anti-oxidation gene expression program to counter oxidative stress.
Changzhou Cai, Huailu Ma, Jin Peng, Xiang Shen, Xinghua Zhen, Chaohui Yu, Pumin Zhang, Feng Ji, Jiewei Wang   +8 more
doaj   +1 more source

Development of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer

Results in Chemistry, 2022
Aberrant hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) has been reported in non-small cell lung cancer through overexpression of the p62/sequestosome1 protein, resulting in the acquisition of malignancy and drug resistance.
Daisuke Yasuda, Ippei Yoshida, Riyo Imamura, Daiki Katagishi, Kyoko Takahashi, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Tadahiko Mashino, Tomoyuki Ohe   +10 more
doaj   +1 more source

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients [PDF]

, 2017
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of antioxidant and antiinflammatory target genes.
Adelaide R. Tousley, Albena T. Dinkova-Kostova, Aleksey G. Kazantsev, Alexei Degterev, Andrew Snyder, Bertrand, Blair R. Leavitt, Cho Low, Clemens Steegborn, Colúm Connolly, David Llères, Donald C. Lo, Ellen Sapp, Eranthie Weerapana, James R. C. Miller, Kimberly Kegel-Gleason, Kobayashi, Leslie M. Thompson, Linda S. Kaltenbach, Lisa A. Crawford, Lisa M. Ellerby, Lisa Meisel, Luisa Quinti, Marian DiFiglia, Matthew Fuszard, Maureen Higgins, Michael A. Schwarzschild, Michael J. Van Kanegan, Möller, Ningzhe Zhang, Petr Vodicka, Phani, Quinti, Ross Stein, Ruth E. Farmer, Sarah J. Tabrizi, Sharadha Dayalan Naidu, Sorolla, Steven M. Hersch, Susanta Samajdar, Sébastien Moniot, Ujjainwalla, Ulrike Träger, Vanita Chopra, Vijay Potluri, Xiqun Chen   +45 more
core   +4 more sources

Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2 [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2010
Arsenic activates nuclear factor erythroid 2-related factor 2 (Nrf2) to induce phase II and antioxidative genes. Here we analyzed arsenic-Kelch-like ECH-associated protein 1 (Keap1) cysteine thiol interaction in Nrf2 activation. Arsenic-based Nrf2 activators, fluorescent biarsenical labeling reagent (FlAsH) and phenylarsine oxide (PAO), were used to ...
Xiaoqing, He, Qiang, Ma
openaire   +2 more sources

Epigenetic Scanning of KEAP1 CpG Sites Uncovers New Molecular-Driven Patterns in Lung Adeno and Squamous Cell Carcinomas

Antioxidants, 2020
Background: The KEAP1/NRF2 (Kelch-like ECH-associated protein 1/nuclear factor erythroid 2–related factor 2) pathway modulates detoxification processes and participates in the resistance of solid tumors to therapy.
Federico Pio Fabrizio, Tommaso Mazza, Stefano Castellana, Angelo Sparaneo, Lucia Anna Muscarella   +4 more
doaj   +1 more source

Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival [PDF]

, 2017
In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of ...
Dinkova-Kostova, Albena T., Hayes, John D.   +1 more
core   +2 more sources

A homozygous Keap1-knockout human embryonic stem cell line generated using CRISPR/Cas9 mediates gene targeting

Stem Cell Research, 2017
Kelch-like ECH-associated protein 1 (keap1) is a cysteine-rich protein that interacts with transcription factor Nrf2 in a redox-sensitive manner, leading to the degradation of Nrf2 (Kim et al., 2014a). Disruption of Keap1 results in the induction of Nrf2-
So-Jung Kim, Omer Habib, Jin-Soo Kim, Hyo-Won Han, Soo Kyung Koo, Jung-Hyun Kim   +5 more
doaj   +1 more source