Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan [PDF]
Biology, 2020 The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering +3 more
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Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain [PDF]
Frontiers in Neuroanatomy, 2022 Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura +6 more
doaj +2 more sources
Isolation of Keratan Sulfate Disaccharide-branched Chondroitin Sulfate E from Mactra chinensis [PDF]
Bio-Protocol, 2017 Glycosaminoglycans (GAGs) including chondroitin sulfate (CS), dermatan sulfate (DS), heparin (HP), heparan sulfate (HS) and keratan sulfate (KS) are linear, sulfated repeating disaccharide sequences containing hexosamine and uronic acid (or galactose in ...
Kyohei Higashi, Toshihiko Toida
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A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns. [PDF]
J Am Chem SocKeratan sulfate (KS) is a proteoglycan that is widely expressed in the extracellular matrix of various tissue types where it performs multiple biological functions. KS is the least understood proteoglycan, which in part is due to a lack of panels of well-
Wu Y +6 more
europepmc +2 more sources
Identification of an Immunoglobulin Paratope Binding to Keratan Sulfate and Expression of a Single-Chain Derivative for Imaging [PDF]
BiomoleculesKeratan sulfate (KS) is a negatively charged carbohydrate linked to proteins. Several KS-bearing structural glycosaminoglycans participate to maintain the homeostasis of a functional extracellular matrix.
Burak Boyraz +2 more
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GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium [PDF]
MoleculesWe recently showed that 6-sulfo sialyl N-acetyllactosamine (LacNAc) in O-linked glycans recognized by the CL40 antibody is abundant in the pleural mesothelium under physiological conditions and that these glycans undergo complementary synthesis by ...
Yoshiko Takeda-Uchimura +6 more
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Metabolic reprogramming and M2 macrophage depletion define the microenvironment of adenomyosis [PDF]
Frontiers in EndocrinologyBackgroundAdenomyosis is a chronic gynecological disorder characterized by the invasion of endometrial tissues into the myometrium of the uterus, with pathophysiology linked to chronic inflammation and metabolic dysregulation.
Xuejiao Bian +7 more
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Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes. [PDF]
PLoS ONE, 2020 Diabetes is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete.
Julie A D Van +10 more
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Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. [PDF]
PLoS ONE, 2013 Biopolymers consist of three major classes, i.e., polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (sugar chains). It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of ...
Kenichi Hirano +15 more
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Skeletal keratan sulfate peptides from different tissues Characterization and alkaline degradation
Biochimica Et Biophysica Acta (BBA) - Protein Structure, 1979 Keratan sulfate-rich peptides were isolated after digestion of proteoglycans from bovine nasal cartilage and bovine nucleus pulposus with chondroitinase ABC, trypsin and chymotrypsin.
D Heinegård, I Axelsson, S Inerot
exaly +1 more source