Results 91 to 100 of about 410,791 (266)

Three-dimensional culture of human meniscal cells: Extracellular matrix and proteoglycan production

BMC Biotechnology, 2008
Background The meniscus is a complex tissue whose cell biology has only recently begun to be explored. Published models rely upon initial culture in the presence of added growth factors. The aim of this study was to test a three-dimensional (3D) collagen
Norton H James, Ingram Jane A, Chow Yin, Mauerhan David, Gruber Helen E, Hanley Edward N, Sun Yubo   +6 more
doaj   +1 more source

A case study: Glycosaminoglycan profiles of autologous chondrocyte implantation (ACI) tissue improves as the tissue matures [PDF]

, 2016
Background Autologous chondrocyte implantation (ACI) has been used to treat cartilage defects in thousands of patients worldwide with good clinical effectiveness 10–20 years after implantation.
Kuiper, NJ, Rees, D, Roberts, S, Sharma, A   +3 more
core   +1 more source

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

The FEBS Journal, EarlyView.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef M. Penninger   +10 more
wiley   +1 more source

Enzyme replacement in a human model of mucopolysaccharidosis IVA in vitro and its biodistribution in the cartilage of wild type mice. [PDF]

PLoS ONE, 2010
Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfatase (GALNS), an enzyme that degrades keratan sulfate (KS). Currently no therapy for MPS IVA is available.
Melita Dvorak-Ewell, Dan Wendt, Chuck Hague, Terri Christianson, Vish Koppaka, Danielle Crippen, Emil Kakkis, Michel Vellard   +7 more
doaj   +1 more source

Microglial subtypes: diversity within the microglial community [PDF]

, 2019
Microglia are brain-resident macrophages forming the first active immune barrier in the central nervous system. They fulfill multiple functions across development and adulthood and under disease conditions. Current understanding revolves around microglia
Joseph, Bertrand, Stratoulias, Vassilis, Tremblay, Marie-Ève, Venero Recio, José Luis   +3 more
core   +1 more source

Isoforms of corneal keratan sulfate proteoglycan.

Journal of Biological Chemistry, 1990
Bovine corneal keratan sulfate proteoglycan was found to contain three major protein components. Two proteins (37 and 25 kDa) were released from the proteoglycan by endo-beta-galactosidase, N-glycanase, or chemical deglycosylation. A smaller protein (20 kDa), not covalently linked to keratan sulfate, co-purified with the proteoglycan by conventional ...
J L, Funderburgh, G W, Conrad
openaire   +2 more sources

Collagen organisation in the fibrous joint capsules in the digits of the human hand

Journal of Anatomy, EarlyView.
The function of the finger joints is important for daily life. In this review of the literature, we consider the role of collagen and its organization within the fibrous finger joint capsules of the interphalangeal (IP) joints and investigate the relationships between collagen orientation and joint function. Abstract Normal function of the hand and, in
Fiona R. Saunders, Ronald G. Coutts, Richard M. Aspden, Flora Gröning   +3 more
wiley   +1 more source

Keratan Sulfate Promotes Periodontitis Progression Via Tlr4/Nf-Κb Pathway

International Dental Journal
Aim or purpose: To explore the metabolic level and regulatory mechanism of keratan sulfate (KS) in periodontitis progression. Materials and methods: KS secretion levels and FUT8 and CHST2 expression, alongside neutrophil and plasma cell infiltration ...
Ziqin Zhao, Mao Xiaoyan, Jiang Wei, Huang Le   +3 more
doaj   +1 more source

Dimethylmethylene Blue Assay (DMMB)

Bio-Protocol, 2014
Glycosaminoglycans (GAGs) are long unbranched polysaccharides consisting of repeating disaccharide units composed of a hexosamine (glucosamine or galactosamine) and a hexuronic acid (glucuronic or iduronic acid).
Vivien Coulson-Thomas, Tarsis Ferreira
doaj   +1 more source

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]

, 2019
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core   +1 more source