Results 81 to 90 of about 410,791 (266)
Iron oxide-coupled CRISPR-nCas9-based genome editing assessment in mucopolysaccharidosis IVA mice
Molecular Therapy: Methods & Clinical Development, 2023 Mucopolysaccharidosis (MPS) IVA is a lysosomal storage disorder caused by mutations in the GALNS gene that leads to the lysosomal accumulation of keratan sulfate (KS) and chondroitin 6-sulfate, causing skeletal dysplasia and cardiopulmonary complications.
Andrés Felipe Leal +5 more
doaj +1 more source
Proteomics for rejection diagnosis in renal transplant patients: where are we now? [PDF]
, 2016 Rejection is one of the key factors that determine the long-term allograft function and survival in renal transplant patients. Reliable and timely diagnosis is important to treat rejection as early as possible.
Gwinner, Wilfried +3 more
core +1 more source
Journal of Biological Chemistry, 1972 Abstract Protein-keratan sulfate core was isolated from bovine nasal cartilage proteoglycan after enzymatically removing chondroitin sulfate with chondroitinase AC from Flavobacterium heparinum. The core preparation exhibited a broad, approximately Gaussian distribution of buoyant densities in CsCl density gradients (between 1.43 and 1.58 g per ml with
V C, Hascall, R L, Riolo
openaire +2 more sources
Advanced Science, EarlyView.This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen +10 more
wiley +1 more source
The Sea as a Rich Source of Structurally Unique Glycosaminoglycans and Mimetics
Microorganisms, 2017 Glycosaminoglycans (GAGs) are sulfated glycans capable of regulating various biological and medical functions. Heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate and hyaluronan are the principal classes of GAGs found in ...
Ariana A. Vasconcelos, Vitor H. Pomin
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 The ocular surface, which forms the interface between the eye and the external environment, includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that produce the tear film.
Sudan Puri +4 more
doaj +1 more source
Evidence for the role of proteoglycans in cation-mediated gene transfer [PDF]
, 1996 We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Baldeschwieler, John D. +1 more
core +1 more source
Keratan Sulfate in Neuronal Network Reconstruction
Trends in Glycoscience and Glycotechnology, 2011 ケラタン硫酸は2糖の繰り返し構造を単位とするグリコサミノグリカンの一つであり、コアプロテインに共有結合することによりケラタン硫酸プロテオグリカンを生ずる。ケラタン硫酸プロテオグリカンは元来角膜抽出物において発見され、また関節軟骨中において豊富に見出されたため、これら組織における構造や生物学的機能が注目されてきた。しかし1980年代に入り中枢神経系においても見出され、神経系の発達や疾患における働きが注目を集めてきた。現在、ケラタン硫酸プロテオグリカンは生理的および損傷後神経可塑性を制御する主要な分子の一つとして受け入れられ始めている。
Kazuma Sakamoto, Kenji Kadomatsu
openaire +2 more sources
Rare Metals, EarlyView.ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu +13 more
wiley +1 more source
Long-Term Liver-Targeted AAV8 Gene Therapy for Mucopolysaccharidosis IVA
Current Issues in Molecular BiologyMucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disease with an autosomal recessive trait caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme, which leads to the accumulation of chondroitin-6-sulfate and ...
Shaukat A. Khan +5 more
doaj +1 more source