Results 101 to 110 of about 845,184 (295)
Regional blood-brain barrier transport of ketone bodies in portacaval-shunted rats
, 1991 The permeability of the blood-brain barrier to ketone bodies, substrates of the monocarboxylic acid carrier, was measured in individual brain structures of control and portacaval-shunted rats.
R. A. Hawkins, A. M. Mans
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Arthroscopy Techniques, EarlyView.Abstract Anterior cruciate ligament (ACL) injury is one of the most common knee disorders, occurring mostly in sports‐related injuries. After injury, knee stability is compromised, leading to further damage to surrounding structures, such as meniscal tears, cartilage wear, and other lesions.
Zongwen Liu +4 more
wiley +1 more source
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease, in which cysts gradually grow in the kidneys leading to a decline in kidney function over time. Eventually, most patients need kidney replacement therapy such as dialysis or kidney transplantation.
openaire +2 more sources
Biotechnology and Bioengineering, EarlyView.ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter +10 more
wiley +1 more source
Ketone body metabolism and cardiovascular disease
American Journal of Physiology-Heart and Circulatory Physiology, 2013 Ketone bodies are metabolized through evolutionarily conserved pathways that support bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when carbohydrates are in short supply. The metabolism of ketone bodies interfaces with the tricarboxylic acid cycle, β-oxidation of fatty acids, de novo lipogenesis, sterol biosynthesis ...
David G, Cotter +2 more
openaire +3 more sources
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
BMEMat, EarlyView.A near‐infrared (NIR) light‐activated “lock‐key” nanodevice is reported for spatiotemporally resolved detection of intratumoral L‐lactate. The system stays silent until deep‐penetrating NIR light remotely unlocks its function, allowing for precise sensing within tumors.
Siyu Pan +8 more
wiley +1 more source
Ketone Bodies and Signaling in Pancreatic Cancer Cell Lines [PDF]
, 2018 Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States, and 95% of these cases are caused by PDAC (pancreatic ductal adenocarcinoma).
Buettner, Kyla B. +2 more
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Hydrophobic modification of poly(aryl ether ketone ketone) aerogel via poly(dimethylsiloxane)
, 2017 Property and structure of aerogels with polar groups almost suffer from their high hydrophilicity. In this study, in order to improve the hydrophobicity of poly(aryl ether ketone ketone) aerogel prepared from poly(aryl ether ketone ketone) containing ...
He, Liu +5 more
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BMEMat, EarlyView.The cervical interbody cage needs to take both biomechanical and biological requirements into account. Here, a new‐style degradable, multicomponent, and bioinspired nacre‐like cervical interbody cage composite, which exhibits promising mechanical‐support‐related behavior and osteogenesis‐related potential, is designed and prepared.
Xiu‐Wu Guo +8 more
wiley +1 more source