Results 1 to 10 of about 970,169 (120)
IEEE Access, 2023 Aiming the problem that the mechanical claw in very few rapid secure devices (RSD) failed to capture the fixed rod of the shipboard helicopter due to the lose effectiveness of the internal shock absorption system of the RSD, a reliability growth test ...
Zhuxin Zhang +5 more
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IEEE Access, 2023 Aiming the chain transmission system in the rapid secure device (RSD) of shipborne helicopter, an individual fault was that the chain was broken, and then the system gave an alarm.
Zhuxin Zhang +5 more
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Development and validation of a stability-indicating HPLC
Pakistan Journal of Pharmaceutical Sciences, 2023 Fosaprepitant dimeglumine, an injectable phosphorylated prodrug of aprepitant, has been approved for preventing chemotherapy-induced nausea and vomiting.
Lili Huang +7 more
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Bioengineering & Translational Medicine, 2023 Ionic liquids (ILs) attract more and more interests in improving drug transport across membrane, including transdermal, nasal, and oral delivery. However, some drawbacks of ILs impede the application in oral drug delivery, such as rapid precipitation of ...
Kaiheng Liu +9 more
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An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases
Nature Communications, 2023 Immune checkpoints play key roles in maintaining self-tolerance. Targeted potentiation of the checkpoint molecule PD-L1 through in situ manipulation offers clinical promise for patients with autoimmune diseases.
Shenqiang Wang +9 more
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Aggregate, 2022 Probing the onset of micellization, or determining the critical micelle concentration (CMC), is of crucial importance while remains to be challenged by growing demand for extraordinary sensitivity and accuracy.
Haisheng He +8 more
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Bioactive Materials, 2022 Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis, which represents a hallmark of Alzheimer's disease (AD) and other age-related neurodegenerative disorders. Growing evidence has implicated
Shuting Xu +11 more
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In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging
Acta Pharmaceutica Sinica B, 2021 In vitro‒in vivo correlation (IVIVC) of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients. Nevertheless, in vivo dissolution profiles have never been accurately portrayed. The
Yinqian Yang +9 more
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Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism
Pharmaceutical Biology, 2021 Context Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. Objective To clarify the
Haihua Shang +7 more
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Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules
Pharmaceuticals, 2022 Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the ...
Luyu Zhang +7 more
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