Results 21 to 30 of about 911,306 (169)

Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism

Pharmaceutical Biology, 2021
Context Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. Objective To clarify the
Haihua Shang, Ze Wang, Hong Ma, Yinghui Sun, Xiaoyan Ci, Yuan Gu, Changxiao Liu, Duanyun Si   +7 more
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Therapies for epidermolysis bullosa: delivery is key [PDF]

British Journal of Dermatology, 2019
Linked Article: https://doi.org/10.1111/bjd.17075.
J. Bremer, P.C. Akker
openaire   +3 more sources

Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules

Pharmaceuticals, 2022
Skin delivery of biomacromolecules holds great advantages in the systemic and local treatment of multiple diseases. However, the densely packed stratum corneum and the tight junctions between keratinocytes stand as formidable skin barriers against the ...
Luyu Zhang, Zirong Dong, Wenjuan Liu, Xiying Wu, Haisheng He, Yi Lu, Wei Wu, Jianping Qi   +7 more
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Scavenger receptor A-mediated nanoparticles target M1 macrophages for acute liver injury

Asian Journal of Pharmaceutical Sciences, 2023
Acute liver injury (ALI) has an elevated fatality rate due to untimely and ineffective treatment. Although, schisandrin B (SchB) has been extensively used to treat diverse liver diseases, its therapeutic efficacy on ALI was limited due to its high ...
Rongping Zhang, Shiqing Luo, Ting Zhao, Mengying Wu, Lu Huang, Ling Zhang, Yuan Huang, Huile Gao, Xun Sun, Tao Gong, Zhirong Zhang   +10 more
doaj   +1 more source

Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride

Pharmaceutics, 2021
Oral propranolol hydrochloride has been the first-line treatment for infantile hemangioma (IH), whereas systemic exposure to propranolol has the potential of causing serious adverse reactions.
Jingjing He, Zichen Zhang, Xianzi Zheng, Lu Li, Jianping Qi, Wei Wu, Yi Lu   +6 more
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Defect Analysis and Innovation Design of Synchronizer for Clutchless Automatic Mechanical Transmission

Chinese Journal of Mechanical Engineering, 2022
The synchronizer is a key component of automatic mechanical transmission (AMT) equipped in electric vehicles, but the inertial lock-ring synchronizer (ILRS) commonly used there is not suitable especially for pure electric vehicles without a clutch ...
Lipeng Zhang, Yunao Peng, Haojie Yang, Shaohua Li   +3 more
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Ionic co-aggregates (ICAs) based oral drug delivery: Solubilization and permeability improvement

Acta Pharmaceutica Sinica B, 2022
Due to the overwhelming percentage of poorly water-soluble drugs, pharmaceutical industry is in urgent need of efficient approaches for solubilization and permeability improvement.
Xianzi Zheng, Zhezheng Fang, Weizi Huang, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu, Yi Lu   +7 more
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Near‐infrared fluorophores with absolute aggregation‐caused quenching and negligible fluorescence re‐illumination for in vivo bioimaging of nanocarriers

Aggregate, 2023
Environment‐responsive fluorophores with aggregation‐caused quenching (ACQ) properties have been applied to track nanocarriers with reduced artefacts caused by unbound or free fluorophores but suffer from incomplete fluorescence quenching and significant
Yifan Cai, Xin Ji, Yunsen Zhang, Chang Liu, Zichen Zhang, Yongjiu Lv, Xiaochun Dong, Haisheng He, Jianping Qi, Yi Lu, Defang Ouyang, Weili Zhao, Wei Wu   +12 more
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Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages

Acta Pharmaceutica Sinica B, 2023
As known, the benefits of photothermal therapy (PTT) are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins (HSPs). Then HSPs further trigger the formation of stress granules (SGs) that regulate protein
Fan Tong, Haili Hu, Yanyan Xu, Yang Zhou, Rou Xie, Ting Lei, Yufan Du, Wenqin Yang, Siqin He, Yuan Huang, Tao Gong, Huile Gao   +11 more
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Guiding a Diclofenac Sodium Dual-Release Sustained Formulation Development Through In Vitro–In Vivo Relationship Based on Physiologically Based Pharmacokinetics

Pharmaceutics
Background: Dual-release sustained formulations enable rapid drug release for prompt therapeutic onset while retaining the characteristics of sustained-release dosage forms. However, due to the complexity of this dosage form, conventional trial-and-error
Qizheng Wang, Pengcheng Guo, Tianci Hu, Longjie Li, Tingxi Zhu, Yue Pan, Xiaoqiang Xiang, Jianxin Wang   +7 more
doaj   +1 more source