Results 21 to 30 of about 2,783,643 (311)

Membrane domain formation—a key factor for targeted intracellular drug delivery [PDF]

Frontiers in Physiology, 2014
Protein molecules, toxins and viruses internalize into the cell via receptor-mediated endocytosis (RME) using specific proteins and lipids in the plasma membrane. The plasma membrane is a barrier for many pharmaceutical agents to enter into the cytoplasm of target cells.
Popov-Celeketic, Dusan, van Bergen en Henegouwen, P   +1 more
openaire   +5 more sources

Ionic co-aggregates (ICAs) based oral drug delivery: Solubilization and permeability improvement

Acta Pharmaceutica Sinica B, 2022
Due to the overwhelming percentage of poorly water-soluble drugs, pharmaceutical industry is in urgent need of efficient approaches for solubilization and permeability improvement.
Xianzi Zheng, Zhezheng Fang, Weizi Huang, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu, Yi Lu   +7 more
doaj   +1 more source

Near‐infrared fluorophores with absolute aggregation‐caused quenching and negligible fluorescence re‐illumination for in vivo bioimaging of nanocarriers

Aggregate, 2023
Environment‐responsive fluorophores with aggregation‐caused quenching (ACQ) properties have been applied to track nanocarriers with reduced artefacts caused by unbound or free fluorophores but suffer from incomplete fluorescence quenching and significant
Yifan Cai, Xin Ji, Yunsen Zhang, Chang Liu, Zichen Zhang, Yongjiu Lv, Xiaochun Dong, Haisheng He, Jianping Qi, Yi Lu, Defang Ouyang, Weili Zhao, Wei Wu   +12 more
doaj   +1 more source

PRONIOSOMES: A KEY TO IMPROVED DRUG DELIVERY

Journal of Drug Delivery and Therapeutics, 2014
In the recent years nanotechnology has brought revolutionary changes in the field of life sciences which includes novel drug delivery systems, diagnostics, nutraceuticals and biomedicals for implants and prosthesis. Sustained and Controlled release drug products are often formulated to permit the establishment and maintenance of drug concentration at ...
Rekha Kumari, Kuldeep Verma, Aatish Verma, Girish Kumar Yadav, Sheo Datta Maurya   +4 more
openaire   +2 more sources

Toward designing a quantum key distribution network simulation model [PDF]

, 2016
As research in quantum key distribution network technologies grows larger and more complex, the need for highly accurate and scalable simulation technologies becomes important to assess the practical feasibility and foresee difficulties in the practical ...
Chromý, Erik, Fazio, Peppino, Mehic, Miralem, Vozňák, Miroslav   +3 more
core   +2 more sources

Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages

Acta Pharmaceutica Sinica B, 2023
As known, the benefits of photothermal therapy (PTT) are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins (HSPs). Then HSPs further trigger the formation of stress granules (SGs) that regulate protein
Fan Tong, Haili Hu, Yanyan Xu, Yang Zhou, Rou Xie, Ting Lei, Yufan Du, Wenqin Yang, Siqin He, Yuan Huang, Tao Gong, Huile Gao   +11 more
doaj   +1 more source

Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle [PDF]

, 2011
The universally conserved signal recognition particle (SRP) and SRP receptor (SR) mediate the cotranslational targeting of proteins to cellular membranes.
Chandrasekar, Sowmya, Neher, Saskia, Nguyen, Thang X., Shan, Shu-ou, Walter, Peter   +4 more
core   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles

Drug Delivery, 2021
Small molecule-chemotherapeutic drug conjugate nanoparticles (SMCDC NPs) has a great advantage in improving drug loading. However, the factors which influence these conjugates forming stable nanoparticles (NPs) are currently unclear.
Mei-Qi Xu, Ting Zhong, Xin Yao, Zhuo-Yue Li, Hui Li, Jing-Ru Wang, Zhen-Han Feng, Xuan Zhang   +7 more
doaj   +1 more source

Exploring anti-corruption capabilities of e-procurement in construction project delivery in Nigeria [PDF]

, 2020
The use of electronic (e-­) procurement to support the execution of supply chain management activities in the different industrial sectors is permeating all regions of the world.
Aduwo, Egidario, Afolabi, Adedeji, Ayo-Vaughan, Emmanuel, Ibem, Eziyi, Oluwunmi, Adedamola, Oni, Aderonke, Tunji-Olayeni, Patience, Uwakonye, Uwakonye   +7 more
core   +2 more sources