Results 111 to 120 of about 1,061,703 (360)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Changes in kidney function in a population with essential hypertension in real life settings [PDF]

, 2017
Introduction. Hypertension has been identified as one of the commonest modifiable determinants for chronic kidney disease progression. A variety of antihypertensive drugs are available and their effect on kidney function has been investigated by a ...
Haidich, Anna-Bettina, Lasaridis, Anastasios N., Mark, Patrick B., Pikilidou, Maria I., Ptinopoulou, Anastasia G., Tziolas, Ioannis M., Zebekakis, Pantelis E.   +6 more
core  

siRNA Delivery to the Glomerular Mesangium Using Polycationic Cyclodextrin Nanoparticles Containing siRNA [PDF]

, 2015
There is an urgent need for new therapies that can halt or reverse the course of chronic kidney disease with minimal side-effect burden on the patient. Small interfering RNA (siRNA) nanoparticles are new therapeutic entities in clinical development that ...
Davis, Mark E., Gale, Aaron, Ma, Rong, Wu, Peiwen, Zuckerman, Jonathan E.   +4 more
core   +3 more sources

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, EarlyView.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source

One‐Step Coordinated Multi‐Kinetic 4D Printing of Human Vascularized Cardiac Tissues with Selective Fast‐Shrinking Capillaries

Advanced Materials, EarlyView.
This study presents a novel 4D bioprinting technique for fabricating cardiac tissues with complex microvasculature. Unlike traditional 3D printing, it enables capillary‐scale structure formation via selective post‐printing shrinkage. This approach overcomes resolution limits of printing cell‐laden hydrogels, allowing the creation of functional ...
Ester Sapir Baruch, Roni Cohen, Eric Silberman, Michael Namestnikov, Itai Cabilly, Assaf Shapira, Tal Dvir   +6 more
wiley   +1 more source

Multiple efferent arterioles of the human kidney glomerulus as observed by scanning electron microscopy of vascular casts.

Archivum histologicum Japonicum = Nihon soshikigaku kiroku, 1985
About three thousand resin vascular casts of human renal glomeruli were examined with a scanning electron microscope, and two extremely rare glomeruli with quadruple or quintuple efferent arterioles were found.
T. Murakami, A. Kikuta, S. Akita, T. Sano   +3 more
semanticscholar   +1 more source

A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature. [PDF]

, 2017
BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint
Adderley, Adderley, Bender, Epstein, Homberg, Kim, Mongillo, Page, Raja Beharelle, Ridding, Saur, Szaflarski, Wade, Zaccolo   +13 more
core   +2 more sources

Advances in Electrochemical Urea Biosensors: Trends and Future Prospects

Advanced Sensor Research, EarlyView.
This review explores advances in enzymatic and non‐enzymatic biosensors, emphasizing electrochemical detection, material innovations, and IoT integration for real‐time tracking. Key challenges and future opportunities in enhancing sensitivity, selectivity, and portability are highlighted, showcasing biosensors as promising tools for next‐generation ...
Samar Shurbaji, Arshad Khan, Mohammad K. Hassan, Amine Bermak, Wen‐Di Li, Kabir H Biswas, Bo Wang   +6 more
wiley   +1 more source

Morphological Description and Histological Structure of Kidney in Barn Owl Tyto alba

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
  The morphological description and histological structure of Kidney in barn owl Tyto alba have been invesigated. The results of present study revealed that barn owl has pair of elongated solid kidney situated symmetrically on both sides of vertebral ...
Isrra A. A. Khadhim, Hussain A. Dauod
doaj  

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source