Results 111 to 120 of about 33,604 (265)
[Interaction between guanylate cyclases in the kidney glomerulus].
Postepy higieny i medycyny doswiadczalnej, 1999 Cyclic GMP mediates regulation of the basic functions in the kidney. The membrane- and cytosolic (soluble) guanylate cyclase systems in the kidney glomeruli modulate reciprocally their activities. In physiological conditions, this compensatory regulation results in maintaining the stable cGMP level.
openaire +1 more source
Arthritis &Rheumatology, EarlyView.Objective Evaluate performance of the Predicting Risk of Cardiovascular Disease Events (PREVENT) calculator in rheumatoid arthritis (RA). Methods Patients with RA were matched up to 10 controls on age, sex, and enrollment year using National Veterans Health Administration, Medicare, and National Death Index data (2006–2020).
Tate M. Johnson +13 more
wiley +1 more source
Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing. [PDF]
Kidney Int, 2018 Eng DG +7 more
europepmc +1 more source
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, ClinicalTrials.gov identifier ...
Andrea Fava +8 more
wiley +1 more source
Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis
Arthritis &Rheumatology, Accepted Article.Objective Systemic lupus erythematosus (SLE) is a multi‐organ disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith +23 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Osteoporosis causes fractures which further increase the disease burden of rheumatoid arthritis (RA), however, osteoporosis treatment rates remain low. While several studies have reported that biologic or targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) can prevent or improve osteoporosis in RA, our large‐scale, real ...
Takafumi Aritomi +30 more
wiley +1 more source
5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng +14 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
British Journal of Clinical Pharmacology, EarlyView.Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source