Results 111 to 120 of about 1,048,911 (270)

Antioxidant‐oxidant balance in the glomerulus and proximal tubule of the rat kidney

, 1998
Wilfried Gwinner, Ute Deters‐Evers, Ralf P. Brandes, B Kubat, Karl‐Martin Koch, Michael E. Pape, Christoph J. Olbricht   +6 more
openalex   +1 more source

11β-Hydroxysteroid Dehydrogenase Type 2 Is Expressed in the Human Kidney Glomerulus

, 2002
Saeko Kataoka, A. Kudo, H. Hirano, H. Kawakami, T. Kawano, E. Higashihara, Hirotoshi Tanaka, F. Delarue, J. Sraer, T. Mune, Z. Krozowski, K. Yan   +11 more
semanticscholar   +1 more source

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Prognostic Implication of CYP2C19 Genotype According to Clinical Risk Stratification After Drug‐Eluting Stent Implantation

Clinical Pharmacology &Therapeutics, EarlyView.
From the nationwide multicenter consortium, 8,163 patients undergoing drug‐eluting stent implantation were classified according to the presence of the CYP2C19 loss‐of‐function (LoF) allele: rapid or normal metabolizers (RMs/NMs) vs. intermediate or poor metabolizers (IMs/PMs), and clinical risk was stratified using the CHADS‐P2A2RC and TRS 2°P scores ...
Hyun Woong Park, Jae‐Hwan Lee, Jin‐Ok Jeong, Diana A. Gorog, Udaya S. Tantry, Byeong‐Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Jin‐Yong Hwang, Young Bin Song, Sung Gyun Ahn, Jung‐Won Suh, Woong Gil Choi, Jung Rae Cho, Jeehoon Kang, Sang Yeub Lee, Hyo‐Soo Kim, Moo Hyun Kim, Do‐Sun Lim, Eun‐Seok Shin, Paul A. Gurbel, Young‐Hoon Jeong, on behalf of the PTRG‐DES Consortium Investigators   +22 more
wiley   +1 more source

Revealing VCAN as a Potential Common Diagnostic Biomarker of Renal Tubules and Glomerulus in Diabetic Kidney Disease Based on Machine Learning, Single-Cell Transcriptome Analysis and Mendelian Randomization [PDF]

Li Jiang, Jie Jian, Xulin Sai, Xiai Wu
openalex   +1 more source

THE EFFECT OF VITAMIN E (α-TOCOPHEROL) ADMINISTRATION ON GLOMERULUS AND PROXIMAL KIDNEY TUBULES DAMAGE WHICH RECEIVED CISPLATIN EXPOSURE ON SPRAGUE DAWLEY MICE

, 2020
Fadhilla Rakhmatiar, Doddy M Soebadi, Soetojo Soetojo   +2 more
openalex   +1 more source

Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.

Developmental Biology, 2008
K. Kanasaki, Y. Kanda, K. Palmsten, H. Tanjore, Soo Bong Lee, Valerie S. LeBleu, V. Gattone, R. Kalluri   +7 more
semanticscholar   +1 more source

Lower Dose‐Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss‐of‐Function Allele Carriers: A Longitudinal Retrospective Real‐World Study in Kidney Transplant Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non‐European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11–19%) but virtually absent in Europeans (MAF: 0.15%)
Amar D. Levens, Dirk Jan A. R. Moes, Yanick Boer, Aiko P. J. de Vries, Dorottya K. de Vries, Danny van der Helm, Soufian Meziyerh, Dave L. Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J. Swen   +10 more
wiley   +1 more source

Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function

, 2020
O. Smithies
openalex   +1 more source

Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus.

Kidney International, 1981
P. Andrews
semanticscholar   +1 more source