Results 21 to 30 of about 215,240 (265)

Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity

Haematologica, 2009
Background Bortezomib is a selective and potent inhibitor of the proteasome and has prominent effects in vitro and in vivo against tumors. Very recently, cytotoxic effects of bortezomib on immune-competent cells such as T cells and dendritic cells were ...
Xiangling Wang, Astrid Ottosson, Chunyan Ji, Xiaoli Feng, Magnus Nordenskjöld, Jan-Inge Henter, Bengt Fadeel, Chengyun Zheng   +7 more
doaj   +1 more source

Multifunctional human CD56low CD16low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients

Haematologica, 2015
We phenotypically and functionally characterized a distinct CD56low natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia.
Helena Stabile, Paolo Nisti, Stefania Morrone, Daria Pagliara, Alice Bertaina, Franco Locatelli, Angela Santoni, Angela Gismondi   +7 more
doaj   +1 more source

Interferon therapy shifts natural killer subsets among Egyptian patients with chronic hepatitis C

Brazilian Journal of Infectious Diseases, 2010
Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors.
Amal Fathy, Mohamed Mohy Eldin, Lobna Metwally, Mohamed Eida, Marwa Abdel-Rehim, Gamal Esmat   +5 more
doaj   +1 more source

Natural killer cells in hepatitis B virus infection

Brazilian Journal of Infectious Diseases, 2015
Natural killer cells are a unique type of lymphocytes with cytotoxic capacity, and play important roles against tumors and infections. Recently, natural killer cells have been increasingly valued in their effects in hepatitis B virus infection.
Shao-fei Wu, Wen-jing Wang, Yue-qiu Gao
doaj   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT

Nature Communications, 2022
Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell ...
Yoav Charpak-Amikam, Tom Lapidus, Batya Isaacson, Alexandra Duev-Cohen, Tal Levinson, Adi Elbaz, Francesca Levi-Schaffer, Nir Osherov, Gilad Bachrach, Lois L. Hoyer, Maya Korem, Ronen Ben-Ami, Ofer Mandelboim   +12 more
doaj   +1 more source

Killer instincts: natural killer cells as multifactorial cancer immunotherapy

Frontiers in Immunology, 2023
Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of ...
Sarah Nersesian, Sarah Nersesian, Emily B. Carter, Emily B. Carter, Stacey N. Lee, Stacey N. Lee, Lauren P. Westhaver, Jeanette E. Boudreau, Jeanette E. Boudreau, Jeanette E. Boudreau   +9 more
doaj   +1 more source

Advances in augmenting infiltration of active natural killer cells into pediatric and adult solid tumors

Molecular Therapy: Oncology
Although adoptive natural killer cell therapies have been safe and somewhat effective in hematological malignancies, their performance in solid tumors is hindered by the solid tumor microenvironment, which impairs natural killer cell trafficking and ...
Shiori Eguchi, Wen Luo, Hongwen Zhu, Jeremy M. Rosenblum, Anna R. Cooper, Mitchell S. Cairo   +5 more
doaj   +1 more source

Highly activated and expanded natural killer cells for multiple myeloma immunotherapy

Haematologica, 2012
Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound ...
Tarun K. Garg, Susann M. Szmania, Junaid A. Khan, Antje Hoering, Paul A. Malbrough, Amberly Moreno-Bost, Amy D. Greenway, Joshuah D. Lingo, Xin Li, Shmuel Yaccoby, Larry J. Suva, Brian Storrie, Guido Tricot, Dario Campana, John D. Shaughnessy, Bijay P. Nair, William T. Bellamy, Joshua Epstein, Bart Barlogie, Frits van Rhee   +19 more
doaj   +1 more source

Natural killer cell-mediated immunopathology in recurrent pregnancy losses

Exploration of Immunology, 2022
Natural killer (NK) cells have a dual role in human reproduction for maternal-fetal tolerance and protection from infection. During the ovarian cycle and pregnancy, peripheral NK (pNK) and uterine NK (uNK) cells dynamically change their proportions and ...
Thanh Luu, Lujain AlSubki, Katherine Wolf, Amy Thees, Umida Ganieva, Svetlana Dambaeva, Kenneth Beaman, Joanne Kwak-Kim   +7 more
doaj   +1 more source