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Natural Killer Cell Memory [PDF]
Immunity, 2015 Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of
Joseph C. Sun +3 more
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In vivo generation of decidual natural killer cells from resident hematopoietic progenitors
Haematologica, 2014 Decidual natural killer cells accumulate at the fetal-maternal interface and play a key role in a successful pregnancy. However, their origin is still unknown.
Laura Chiossone +9 more
doaj +1 more source
Organ-specific features of natural killer cells. [PDF]
, 2011 Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio +3 more
core +1 more source
Current Biology, 1999 Perhaps, but probably not a long or healthy life. There is only one documented human case of an absolute NK cell deficiency, which was associated with recurrent life-threatening bacterial and viral infections.
openaire +3 more sources
SnapShot: Natural Killer Cells
Cell, 2020 NK cells are broadly distributed innate lymphoid cells (ILCs) encompassing distinct populations based on CD11b and CD27 expression in mice or CD56 intensity in humans. Involved in anti-viral and anti-tumor immunity thanks to their cytokines and chemokines secretion as well as their cytotoxic capabilities, NK cells have emerged as a promising ...
Crinier, Adeline +3 more
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Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells
Haematologica, 2016 Natural killer cells are key cells of the innate immune system. Natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Loredana Ruggeri +10 more
doaj +1 more source
Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. [PDF]
PLoS ONE, 2015 The analysis of gene function in mature and activated natural killer cells has been hampered by the lack of model systems for Cre-mediated recombination in these cells.
Yiying Xu +4 more
doaj +1 more source
Therapeutic Applications: Natural Killer Cells [PDF]
Journal of Clinical and Diagnostic Research, 2018 Natural Killer (NK) cells are potent cytotoxic effector cells for cancer therapy and also for keeping severe viral infections in check. Since, they represent only 10% of the lymphocytes and are often dysfunctional, there are technical challenges in ...
Preeti Sharma +2 more
doaj +1 more source
Dynamics of Natural Killer cell receptor revealed by quantitative analysis of photoswitchable protein [PDF]
Biophysical Journal, Volume 105, 1-10, (2013), 2013 Natural Killer (NK) cell activation is dynamically regulated by numerous activating and inhibitory surface receptors that accumulate at the immune synapse. Quantitative analysis of receptor dynamics has been limited by methodologies which rely on indirect measurements such as fluorescence recovery after photobleaching.
arxiv +1 more source
Stochastic model of T Cell repolarization during target elimination (II) [PDF]
, 2021 Cytotoxic T lymphocytes (T cells) and natural killer cells form a tight contact, the immunological synapse (IS), with target cells, where they release their lytic granules containing perforin/granzyme and cytokine containing vesicles. During this process the cell repolarizes and moves the microtubule organizing center (MTOC) towards the IS.
arxiv +1 more source