Results 41 to 50 of about 639,100 (318)
Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension [PDF]
, 2012 BACKGROUND: Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling.
Campbell, Kate +17 more
core +1 more source
Unraveling Natural Killer T-Cells Development
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
doaj +1 more source
Nature Communications, 2022 Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell ...
Yoav Charpak-Amikam +12 more
doaj +1 more source
Unbinding and unfolding of adhesion protein complexes through stretching: Interplay between shear and tensile mechanical clamps [PDF]
Proteins: Structure, Function, and Bioinformatics 82 (2014)
3144-3153, 2015 Using coarse-grained molecular dynamics simulations, we analyze mechanically induced dissociation and unfolding of the protein complex CD48-2B4. This heterodimer is an indispensable component of the immunological system: 2B4 is a receptor on natural killer cells whereas CD48 is expressed on surfaces of various immune cells. So far, its mechanostability
arxiv +1 more source
Atividade lítica de células natural "killer" durante a infecção pelo HIV-1 em indivíduos brasileiros [PDF]
, 2001 Natural killer cells are increasingly being considered an important component of innate resistance to viruses, but their role in HIV infection is controversial.
Carvalho, Anderson +2 more
core +3 more sources
Highly activated and expanded natural killer cells for multiple myeloma immunotherapy
Haematologica, 2012 Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound ...
Tarun K. Garg +19 more
doaj +1 more source
Haematologica, 2010 Background Natural killer cells have been demonstrated to exert remarkable graft-versus-leukemia effects after haploidentical transplantation. Acquisition of both, inhibiting and activating, receptors on developing natural killer cells is an important ...
Matthias M. Pfeiffer +6 more
doaj +1 more source
A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies [PDF]
, 2010 A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells.
arxiv +1 more source
Deprenyl, an old drug with new anticancer potential: Mini review [PDF]
arXiv, 2021 The anticancer potential of monoamine oxidase (MAO) was observed in pre-clinical assays conducted with cell cultures and animals. L-Deprenyl (DEP) causes apoptosis in melanoma, leukemia and mammary cells. High-dose DEP has shown toxicity in mammary and pituitary cancers, as well as in monoblastic leukemia, in rats.
arxiv
Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster. [PDF]
PLoS ONE, 2018 The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little is known about the interplay between natural killer cells and psychological stress in the pathogenesis of herpes zoster.
Choon Kwan Kim +5 more
doaj +1 more source