Results 71 to 80 of about 3,594,281 (409)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
, 2010 Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of ...
Hernandez, Marylens +4 more
core +1 more source
Regulation of NLRP3 Inflammasome by Phosphorylation
Frontiers in Immunology, 2018 The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Nan Song, Nan Song, Tao Li, Tao Li
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes [PDF]
, 1991 We have studied the relationship between insulin activation of insulin-receptor kinase and insulin stimulation of glucose uptake in isolated rat adipocytes.
Drenkhan, M. +4 more
core
Purification and Characterization of a Chloroplast Outer-Envelope-Bound, ATP-Dependent Protein Kinase [PDF]
, 1988 An ATP-dependent protein kinase was partially purified from isolated outer envelope membranes of pea (Pisum sativum L., Progress No. 9) chloroplasts. The purified kinase had a molecular weight of 70 kilodaltons, as determined by sodium dodecyl sulfate ...
Soll, Jürgen
core +2 more sources
Targeting Phosphatases and Kinases: How to Checkmate Cancer
Frontiers in Cell and Developmental Biology, 2021 Metastatic disease represents the major cause of death in oncologic patients worldwide. Accumulating evidence have highlighted the relevance of a small population of cancer cells, named cancer stem cells (CSCs), in the resistance to therapies, as well as
Alice Turdo +13 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R [PDF]
, 2000 Background: Vaccinia virus gene B1R encodes a erine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection.
Beaud, G. +4 more
core +3 more sources
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C19H17N5O2, monoclinic, C2/c (no. 15), a = 14.734(6) Å, b = 13.565(5) Å, c = 33.385(12) Å, β = 91.311(9)°, V = 6671(4) Å3, Z = 16, Rgt(F) = 0.0638, wRref(F2) = 0.1783, T = 293(2) K.
Fang Bo, Meng Jiang Ping, Gan Lin Ling
doaj +1 more source