Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]
, 2017 c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie +15 more
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Heart failure induced by perinatal ablation of cardiac myosin light chain kinase
Frontiers in Physiology, 2016 Background: Germline knockout mice are invaluable in understanding the function of the targeted genes. Sometimes, however, unexpected phenotypes are encountered, due in part to the activation of compensatory mechanisms.
Yasmin F. K. Islam +4 more
doaj +1 more source
HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis [PDF]
, 2018 Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic materials.
A Konishi +65 more
core +1 more source
Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]
, 2003 Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S. +3 more
core
Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. [PDF]
, 2015 Casein kinase 1δ (CK1δ) family members associate with microtubule-organizing centers (MTOCs) from yeast to humans, but their mitotic roles and targets have yet to be identified.
Agard, David A +10 more
core +1 more source
Signaling at the membrane interface by the DGK/SK enzyme family
Journal of Lipid Research, 2009 The sphingosine (SK) and diacylglycerol (DGK) kinases have become the subject of considerable focus recently due to their involvement as signaling enzymes in a variety of important biological processes.
Daniel M. Raben, Binks W. Wattenberg
doaj +1 more source
Cell cycle regulation of a Xenopus Wee1-like kinase [PDF]
, 1995 Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner.
Coleman, Thomas R. +2 more
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EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5 [PDF]
, 2013 Background: Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells.
Buday, László +5 more
core +1 more source
Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction
Frontiers in Molecular Neuroscience, 2019 Associative long-term memories (LTMs) support long-lasting behavioral changes resulting from sensory experiences. Retrieval of a stable LTM by means of a large number of conditioned stimulus (CS) alone presentations produces inhibition of the original ...
Mario Rafael Pagani +2 more
doaj +1 more source
Plasma membrane association by N-acylation governs PKG function in Toxoplasma gondii [PDF]
, 2017 Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for microneme secretion, motility, invasion, and egress in apicomplexan parasites, However, the separate roles of two isoforms of the kinase that are expressed by some ...
Brown, Kevin M +2 more
core +2 more sources