Results 91 to 100 of about 94,650 (353)
Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts
bioRxiv, 2018 Neuronal polarity relies on the selective localization of cargo to axons or dendrites. The molecular motor kinesin-1 moves cargo into axons but is also active in dendrites.
Michael T Kelliher +6 more
semanticscholar +1 more source
A look into kinesin's powerhouse [PDF]
FEBS Letters, 2001 Kinesins are microtubule‐dependent motors that serve a multitude of cellular purposes. The conserved motor domain provides the energy required for these processes. Shortly after the solution of the first kinesin motor domain crystal structures the similarity to myosin and G‐proteins was noted.
openaire +3 more sources
Proposed Mechanism of Kinesin Backstepping [PDF]
Biophysical Journal, 2019 AbstractKinesin-1 is an ATP-driven molecular motor that transports cellular cargo along microtubules. At low loads, kinesin-1 almost always steps forwards, towards microtubule plus ends, but at higher loads, it can also step backwards. Backsteps are usually 8 nm, but can be larger. These larger backwards events of 16 nm, 24 nm or more are thought to be
Algirdas Toleikis +2 more
openaire +9 more sources
Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain
Advanced Materials, EarlyView.A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng +11 more
wiley +1 more source
Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport. [PDF]
PLoS ONE, 2011 In the filamentous fungus Aspergillus nidulans, both microtubules and actin filaments are important for polarized growth at the hyphal tip. Less clear is how different microtubule-based and actin-based motors work together to support this growth. Here we
Jun Zhang +7 more
doaj +1 more source
Advanced Science, EarlyView.In this study, we provided new evidence identifying multinucleated cysts as precursors for oocyte differentiation. Within these cysts, organelles migrate and aggregate to form Balbiani body (B‐body) and establish early cellular polarity. Concurrently, excess nuclei are expelled, enabling cyst‐to‐oocyte differentiation. The microfilament‐myosin II plays
Rui Xu +7 more
wiley +1 more source
Mechanical control of the directional stepping dynamics of the kinesin motor
, 2007 Among the multiple steps constituting the kinesin's mechanochemical cycle, one of the most interesting events is observed when kinesins move an 8-nm step from one microtubule (MT)-binding site to another.
Asenjo +25 more
core +2 more sources
SPG10 is a rare cause of spastic paraplegia in European families [PDF]
, 2008 Background: SPG10 is an autosomal dominant form of hereditary spastic paraplegia (HSP), which is caused by mutations in the neural kinesin heavy chain KIF5A gene, the neuronal motor of fast anterograde axonal transport.
Auer-Grumbach, M. +10 more
core +2 more sources
Traffic : the International Journal of Intracellular Transport, 2019 Bidirectional cargo transport along microtubules is carried out by opposing teams of kinesin and dynein motors. Despite considerable study, the factors that determine whether these competing teams achieve net anterograde or retrograde transport in cells ...
Kazuka G. Ohashi +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li +4 more
wiley +1 more source