Results 81 to 90 of about 51,301 (248)
Cell ReportsSummary: Each cargo in a cell employs a unique set of motor proteins for its transport. To dissect the roles of each type of motor, we developed optogenetic inhibitors of endogenous kinesin-1, -2, -3 and dynein motors and examined their effect on the ...
Sahil Nagpal +7 more
doaj +1 more source
In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization [PDF]
, 2008 oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, its mechanism is controversial and ...
Gilchrist, Michael J. +6 more
core +1 more source
The Kinesin Speed Paradox Revisited: How Can Cargoes Move Faster Than Their Motors?
Cytoskeleton, EarlyView.ABSTRACT Intracellular transport is essential for cellular organization and function. Kinesin‐1, the founding member of the kinesin superfamily, delivers a wide range of cargoes along microtubules. Since its discovery, extensive work has identified cargo–kinesin interactions and regulatory mechanisms.
Kanako Iwasaki, Yasushi Okada
wiley +1 more source
Hyperactive KIF5A in Neurodegeneration
Cytoskeleton, EarlyView.ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos +1 more
wiley +1 more source
A moving kinesin motor protein
, 2013 Shows two heads of the kinesin dimer work in a coordinated manner to move processively along the track. The coiled coil (gray) extends towards the top and leads up to the kinesin cargo. Each catalytic core (blue) is bound to a tubulin heterodimer (green,
Vale, Ronald D., Milligan, Ronald A.
core +2 more sources
Kinesin-II-associated intraflagellar transport particles contain large protein complexes
, 1998 Kinesin-II-associated intraflagellar transport particles contain large protein ...
J Fuster (13719088) +5 more
core +1 more source
KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons
Cytoskeleton, EarlyView.ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung +5 more
wiley +1 more source
Nature Communications, 2017 Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule ...
Sergio A. Rincon +7 more
doaj +1 more source
Hot and Splicey: Kinesin Isoforms Seek Attention
Cytoskeleton, EarlyView.ABSTRACT Kinesins family members (KIFs) are encoded in mammals by approximately 45 genes, which are grouped into 14 families based on structural and functional features. As cells increased in complexity, so too did the demand for specialized kinesin‐mediated processes, including intracellular transport, cytoskeletal organization, and cell division. One
C. Belhadi, M. A. Silverman
wiley +1 more source
Protein Glutamylation: From Cytoskeleton to Signaling
Med Research, EarlyView.Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen +4 more
wiley +1 more source